Toxicology Exam 3
1. T/F: Injecting a compound in an insoluble form (in oil or in a solid form) into
muscle or sub-cutaneous can be used to approximate zero order absorption of
the compound: T
2. T/F: The process of elimination for phenytoin is zero order, so that half-life of
a dose of phenytoin could be determined from the equation t 1/2=In2/k, where
k is the rate of elimination: F
3. T/F: The first step in the transformation of a cell to carcinogenesis is damage
to the cell's DNA: T
4. T/F: Once a tumor suppressor or oncogene has been modified by mutation,
the cell is destined to continue through the steps of carcinogenesis although it
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, may take twenty or more years for the cancer to develop: F
5. T/F: Xeroderma pigmentosum is a genetic disease that has been traced back
to a defect in the gene that codes for a methyltransferase DNA repair enzyme: F
6. T/F: The Ames test is based on a prokaryotic model and is designed to test
chemicals for their carcinogenic potential: F
7. T/F: The critical period for most types of malformations occur just before or
just after the embryo implants in the uterine wall (about day 5-7): F
8. T/F: Because the pH of the fetus' plasma is slightly different than that of the
mother, weak acids that make it across the placental barrier will tend to be
retained in the fetus: F
9. Fill in the blank: If a compound is being eliminated by the rate
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1. T/F: Injecting a compound in an insoluble form (in oil or in a solid form) into
muscle or sub-cutaneous can be used to approximate zero order absorption of
the compound: T
2. T/F: The process of elimination for phenytoin is zero order, so that half-life of
a dose of phenytoin could be determined from the equation t 1/2=In2/k, where
k is the rate of elimination: F
3. T/F: The first step in the transformation of a cell to carcinogenesis is damage
to the cell's DNA: T
4. T/F: Once a tumor suppressor or oncogene has been modified by mutation,
the cell is destined to continue through the steps of carcinogenesis although it
1/3
, may take twenty or more years for the cancer to develop: F
5. T/F: Xeroderma pigmentosum is a genetic disease that has been traced back
to a defect in the gene that codes for a methyltransferase DNA repair enzyme: F
6. T/F: The Ames test is based on a prokaryotic model and is designed to test
chemicals for their carcinogenic potential: F
7. T/F: The critical period for most types of malformations occur just before or
just after the embryo implants in the uterine wall (about day 5-7): F
8. T/F: Because the pH of the fetus' plasma is slightly different than that of the
mother, weak acids that make it across the placental barrier will tend to be
retained in the fetus: F
9. Fill in the blank: If a compound is being eliminated by the rate
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