💨 Chapter 9: Cellular Respiration and Fermentation
Cellular Respiration is the catabolic pathway that breaks down organic molecules (like glucose)
using oxygen to release energy for ATP production.
C6 H12 O6 + 6O2 → 6CO2 + 6H2 O + Energy (ATP + Heat)
1. Aerobic Respiration: The Four Stages
Aerobic respiration occurs in the presence of Oxygen (O2 ) and yields about 30-32 ATP per
glucose molecule.
Stage Location Main Input Main Output ATP Yield
1. Cytosol 1 Glucose (6C) 2 Pyruvate 2 ATP
Glycoly (3C), 2 ATP
sis (net),
2 NADH
2. Mitochondrial Matrix 2 Pyruvate 2 Acetyl CoA 0 ATP
Pyruvat (2C), 2 CO2 ,
e 2 NADH
Oxidati
on
3. Citric Mitochondrial Matrix 2 Acetyl CoA 4 CO2 ,
2 ATP
Acid 6 NADH,
Cycle ( 2 FADH2
TCA)
4. Inner Mitochondrial Membrane NADH/FADH2
H2 O
∼ 26-28 ATP
Oxidati , O2
ve
Phosph
orylatio
n
High-Energy Electron Carriers
NADH and FADH2 are reduced (high-energy) carriers produced in stages 1-3.
They carry electrons to the final stage, Oxidative Phosphorylation.
2. Oxidative Phosphorylation: The Powerhouse
This stage uses the energy stored in NADH and FADH2 to make the majority of ATP.
A. Electron Transport Chain (ETC)
Location: Inner Mitochondrial Membrane.
Process: NADH and FADH2 drop off electrons to a chain of protein complexes. As electrons
move down the chain, energy is released and used to pump Hydrogenions from the
Cellular Respiration is the catabolic pathway that breaks down organic molecules (like glucose)
using oxygen to release energy for ATP production.
C6 H12 O6 + 6O2 → 6CO2 + 6H2 O + Energy (ATP + Heat)
1. Aerobic Respiration: The Four Stages
Aerobic respiration occurs in the presence of Oxygen (O2 ) and yields about 30-32 ATP per
glucose molecule.
Stage Location Main Input Main Output ATP Yield
1. Cytosol 1 Glucose (6C) 2 Pyruvate 2 ATP
Glycoly (3C), 2 ATP
sis (net),
2 NADH
2. Mitochondrial Matrix 2 Pyruvate 2 Acetyl CoA 0 ATP
Pyruvat (2C), 2 CO2 ,
e 2 NADH
Oxidati
on
3. Citric Mitochondrial Matrix 2 Acetyl CoA 4 CO2 ,
2 ATP
Acid 6 NADH,
Cycle ( 2 FADH2
TCA)
4. Inner Mitochondrial Membrane NADH/FADH2
H2 O
∼ 26-28 ATP
Oxidati , O2
ve
Phosph
orylatio
n
High-Energy Electron Carriers
NADH and FADH2 are reduced (high-energy) carriers produced in stages 1-3.
They carry electrons to the final stage, Oxidative Phosphorylation.
2. Oxidative Phosphorylation: The Powerhouse
This stage uses the energy stored in NADH and FADH2 to make the majority of ATP.
A. Electron Transport Chain (ETC)
Location: Inner Mitochondrial Membrane.
Process: NADH and FADH2 drop off electrons to a chain of protein complexes. As electrons
move down the chain, energy is released and used to pump Hydrogenions from the