NR 565 Pharmacology Week 4 – 2025/2026
Updated Study Guide & Practice Questions |
100% Pass Guarantee
Most common inflammatory form of arthritis - correct answerGout
Characteristics: RA - correct answerRapid onset
3:1 in women/men
Age 35-50 years at onset
Affects hands and feet
local and systemic inflammation
60 mins morning joint stiffness
Symmetric
Elevated ESR
Leukocytosis
Systemic symptoms
RA symptoms - correct answerPain
Swelling
Warmth
Stiffness
Characteristics: Osteoarthritis - correct answerSlow onset (years)
1:1 in men/women
Age > 50 years at onset
Affects hands, hips, knees
Mild or local inflammation
< 30 min morning joint stiffness
symmetric or asymmetric pattern
ESR normal
Mild leukocytosis
No systemic symptoms
Symptoms: Osteoarthritis - correct answerPain
Bone enlargement
Treatment goals: RA - correct answerRelieve symptoms
Maintain joint function and ROM
Decrease systemic involvement
Delay disease progression
, Medications: RA - correct answerNSAIDS
Glucocorticoids
Conventional DMARDS
Biologic DMARDS
Mechanism of action: Conventional DMARDs - correct answerImmunosuppressant
Inhibits dihydrofolate reductase
Inhibits lymphocyte proliferation
Folate antagonist
Mechanism of action: Bioloic DMARDs - correct answerInhibits JAK 1,2,3 = disruption of
cytokine and growth factor signaling pathways
Mechanism of action: Targeted DMARDs - correct answerBinds to and inhibits tumor
necrosis factor alpha = decreased inflammation and altered immune response
Medications: Conventional DMARDs - correct answerMethotrexate
Sulfasalazine (azulfidine)
Leflunomide (arava)
Hydroxychloroquine (plaquenil)
Medications: Biologic DMARDs - correct answerAdalimumab (Humira)
Certolizumab pegol (cimzia)
Etanercept (Enbrel)
Golimumab (Simponi)
Medications: Targeted DMARDs - correct answerTofacitinib
Baricitinib
DMARD prescribing considerations - correct answerObtain baseline CBC w/WBC
differential
Assess for s/s of infection (TB/hepatitis) and malignancies
R/O pregnancy
Assess risk for immunocompetence (liver/renal status)
Comprehensive H+P to establish baseline
Screen for TB
Baseline diagnostic data: Conventional DMARDs - correct answerALT, AST, serum
creatinine
Baseline diagnostic data: Methotrexate - correct answerChest x-ray, pulmonary + GI
status
Baseline diagnostic data: Sulfasalazine - correct answerChest x-ray, pulmonary +
neurological status
Updated Study Guide & Practice Questions |
100% Pass Guarantee
Most common inflammatory form of arthritis - correct answerGout
Characteristics: RA - correct answerRapid onset
3:1 in women/men
Age 35-50 years at onset
Affects hands and feet
local and systemic inflammation
60 mins morning joint stiffness
Symmetric
Elevated ESR
Leukocytosis
Systemic symptoms
RA symptoms - correct answerPain
Swelling
Warmth
Stiffness
Characteristics: Osteoarthritis - correct answerSlow onset (years)
1:1 in men/women
Age > 50 years at onset
Affects hands, hips, knees
Mild or local inflammation
< 30 min morning joint stiffness
symmetric or asymmetric pattern
ESR normal
Mild leukocytosis
No systemic symptoms
Symptoms: Osteoarthritis - correct answerPain
Bone enlargement
Treatment goals: RA - correct answerRelieve symptoms
Maintain joint function and ROM
Decrease systemic involvement
Delay disease progression
, Medications: RA - correct answerNSAIDS
Glucocorticoids
Conventional DMARDS
Biologic DMARDS
Mechanism of action: Conventional DMARDs - correct answerImmunosuppressant
Inhibits dihydrofolate reductase
Inhibits lymphocyte proliferation
Folate antagonist
Mechanism of action: Bioloic DMARDs - correct answerInhibits JAK 1,2,3 = disruption of
cytokine and growth factor signaling pathways
Mechanism of action: Targeted DMARDs - correct answerBinds to and inhibits tumor
necrosis factor alpha = decreased inflammation and altered immune response
Medications: Conventional DMARDs - correct answerMethotrexate
Sulfasalazine (azulfidine)
Leflunomide (arava)
Hydroxychloroquine (plaquenil)
Medications: Biologic DMARDs - correct answerAdalimumab (Humira)
Certolizumab pegol (cimzia)
Etanercept (Enbrel)
Golimumab (Simponi)
Medications: Targeted DMARDs - correct answerTofacitinib
Baricitinib
DMARD prescribing considerations - correct answerObtain baseline CBC w/WBC
differential
Assess for s/s of infection (TB/hepatitis) and malignancies
R/O pregnancy
Assess risk for immunocompetence (liver/renal status)
Comprehensive H+P to establish baseline
Screen for TB
Baseline diagnostic data: Conventional DMARDs - correct answerALT, AST, serum
creatinine
Baseline diagnostic data: Methotrexate - correct answerChest x-ray, pulmonary + GI
status
Baseline diagnostic data: Sulfasalazine - correct answerChest x-ray, pulmonary +
neurological status
