Pharmacokinetics Quiz 1 Question Bank Questions and Answers | Latest Version | 2025/2026 | Correct & Verified

Pharmacokinetics Quiz 1 Question Bank Questions and Answers | Latest Version | 2025/2026 | Correct & Verified Which process describes the movement of a drug from its site of administration into the bloodstream? A. Distribution B. Metabolism C. Absorption D. Excretion What is the term for the portion of a drug that reaches systemic circulation unchanged? A. Bioavailability B. Half-life C. Bioavailability D. Clearance Which route of drug administration avoids first-pass metabolism? A. Oral 2 B. Rectal C. Intravenous D. Enteral What is the primary organ responsible for drug metabolism? A. Kidney B. Lung C. Liver D. Spleen Which pharmacokinetic parameter describes the rate at which a drug is removed from the body? A. Volume of distribution B. Clearance C. Half-life D. Bioavailability The half-life of a drug is: A. The time to reach peak concentration 3 B. The time for drug absorption C. The time for plasma concentration to decrease by 50% D. The time to onset of action Which factor increases drug absorption from the gastrointestinal tract? A. Low blood flow B. Food presence C. High lipid solubility D. High molecular weight Which process describes the reversible movement of a drug between blood and tissues? A. Distribution B. Absorption C. Metabolism D. Excretion What is the primary route of drug excretion for most water-soluble drugs? A. Feces 4 B. Urine C. Sweat D. Exhaled air Which enzyme system is most involved in Phase I drug metabolism? A. UDP-glucuronosyltransferase B. Cytochrome P450 C. Glutathione S-transferase D. Sulfotransferase A drug with a large volume of distribution (Vd) is likely: A. Confined to plasma B. Widely distributed into tissues C. Rapidly excreted D. Poorly absorbed Which factor decreases the rate of drug metabolism? A. Liver enzyme induction