UAMS Immunology Exam 4 UPDATED
ACTUAL Questions and CORRECT
Answers
transient hypogammaglobulinemia of infancy
X linked Bruton's agammaglobulinemia
IgA deficiency
common variable immunodeficiency (CVI) - CORRECT ANSWER - list the primary
deficiencies of the B cell system.
DiGeorge anomaly
purine-nucleoside phosphorylase (PNP) deficiency - CORRECT ANSWER - list the
cellular immunity deficiencies.
severe combined immunodeficiency (SCID)
wiskott-aldrich syndrome (WAS)
ataxia-telangiectasia (AT) - CORRECT ANSWER - list the combined deficiencies of
cellular and humoral immunity.
oxidative metabolism disorders (chronic granulomatous dz and myeloperoxidase deficiency)
leukocyte adhesion molecule deficiency - CORRECT ANSWER - list the two types of
neutrophil function defects.
secondary immune deficiency - CORRECT ANSWER - what is an abnormality due to
another disorder, infection, or treatment?
malignancies: hodgkins dz and lymphoma, leukemia, myeloma, macroglobulinemia
infections: bacterial, viral, protozoan, helminthic, fungal; most prominent among these is AIDS
, other conditions: burns, diabetes, malnutrition, surgical trauma, renal malfunction, aging,
alcoholic cirrhosis - CORRECT ANSWER - list the secondary immune deficiencies.
transient hypogammaglobulinemia of infancy - CORRECT ANSWER - what is the
deficiency?
prolonged low Ig levels, children have problems with infections, and delay in Ig levels attributed
to poor T cell help
X linked brutons agammaglobulinemia - CORRECT ANSWER - what is the deficiency?
development of B cell blocked at pro-B cell to pre-B cell, deficient in tyrosine kinase,
small/absent and abnormal lymphoid tissue, persitent beyond 2 years of age, treat with Ig
preparation
IgA deficiency - CORRECT ANSWER - what is the deficiency?
most common congenital immunodeficiency, most asymptomatic, anti-antibodies produced by
some (cause anaphylaxsis following transfusion), replacement therapy not useful
common variable immunodeficiency (CVI) - CORRECT ANSWER - what is the
deficiency?
normal # of B cells, cannot differentiate into Ig producing cells, usually in 20s and 30s,
manifestations (malabsorption/diarrhea, malignancies, autoimmune disorders), IgG & IgA
deficient, recurrent infections, treat with Ig preparations and antibiotics
DiGeorge anomaly - CORRECT ANSWER - what is the deficiency?
missing portion of chromosome 22, embryonic development defect in thymus and other organs,
insufficient # of mature T cells, treat with fetal thymus and BM transplant and thymic hormones
ACTUAL Questions and CORRECT
Answers
transient hypogammaglobulinemia of infancy
X linked Bruton's agammaglobulinemia
IgA deficiency
common variable immunodeficiency (CVI) - CORRECT ANSWER - list the primary
deficiencies of the B cell system.
DiGeorge anomaly
purine-nucleoside phosphorylase (PNP) deficiency - CORRECT ANSWER - list the
cellular immunity deficiencies.
severe combined immunodeficiency (SCID)
wiskott-aldrich syndrome (WAS)
ataxia-telangiectasia (AT) - CORRECT ANSWER - list the combined deficiencies of
cellular and humoral immunity.
oxidative metabolism disorders (chronic granulomatous dz and myeloperoxidase deficiency)
leukocyte adhesion molecule deficiency - CORRECT ANSWER - list the two types of
neutrophil function defects.
secondary immune deficiency - CORRECT ANSWER - what is an abnormality due to
another disorder, infection, or treatment?
malignancies: hodgkins dz and lymphoma, leukemia, myeloma, macroglobulinemia
infections: bacterial, viral, protozoan, helminthic, fungal; most prominent among these is AIDS
, other conditions: burns, diabetes, malnutrition, surgical trauma, renal malfunction, aging,
alcoholic cirrhosis - CORRECT ANSWER - list the secondary immune deficiencies.
transient hypogammaglobulinemia of infancy - CORRECT ANSWER - what is the
deficiency?
prolonged low Ig levels, children have problems with infections, and delay in Ig levels attributed
to poor T cell help
X linked brutons agammaglobulinemia - CORRECT ANSWER - what is the deficiency?
development of B cell blocked at pro-B cell to pre-B cell, deficient in tyrosine kinase,
small/absent and abnormal lymphoid tissue, persitent beyond 2 years of age, treat with Ig
preparation
IgA deficiency - CORRECT ANSWER - what is the deficiency?
most common congenital immunodeficiency, most asymptomatic, anti-antibodies produced by
some (cause anaphylaxsis following transfusion), replacement therapy not useful
common variable immunodeficiency (CVI) - CORRECT ANSWER - what is the
deficiency?
normal # of B cells, cannot differentiate into Ig producing cells, usually in 20s and 30s,
manifestations (malabsorption/diarrhea, malignancies, autoimmune disorders), IgG & IgA
deficient, recurrent infections, treat with Ig preparations and antibiotics
DiGeorge anomaly - CORRECT ANSWER - what is the deficiency?
missing portion of chromosome 22, embryonic development defect in thymus and other organs,
insufficient # of mature T cells, treat with fetal thymus and BM transplant and thymic hormones
