ONS-ONCC CHEMOTHERAPY-IMMUNOTHERAPY LESSON 11 TARGETED THERAPIES EXAM

ONS-ONCC CHEMOTHERAPY-IMMUNOTHERAPY LESSON
11 TARGETED THERAPIES EXAM QUESTIONS WITH
CORRECT ANSWERS
HowFtargetedFtherapyFandFchemoFdifferF-FCORRECTFANSWERS-
targetedFtherapiesFactFonFspecificFmolecularFtargetsFonForFwithinFtheFcellsFthatFareFassociatedFwith
Fcancer,FwhereasFstandardFchemoFactFonFallFrapidlyFdividingFcells-chemoFhasFmoreFSEs-


targetedFtherapyFaeFchosenFandFdesignedFtoFinteractFwithFtheirFtargetFonForFwithinFtheFcells,Fwher
easFchemoFwereFIDedFbecausedFtheyFkillFcells-
targetedFtherapiesFareFoftenFcytostaticF(theyFblockFtumorFcellFproliferation)FwhereasFchemoFagent
sFareFcytotoxicF(killFtumorFcells)



GoalsFofFtargetedFtherapyF-FCORRECTFANSWERS-
diseaseFcureFwhenFusedFasFprimaryForFadjuvantFtherapy

-improvingFoverallFresponseForFincreaseFdisease-
freeFsurvivalFwhenFusedFinFcombinationFwithFconventionalFtherapies

-controllingForFstabilizingFdisease

-maintainingForFenhancingFqualityFofFlife

-decreasingFtheFseverityFofFtoxicitiesFfromFotherFtherapies



LigandF-
FCORRECTFANSWERSaFsubstanceFthatFformsFaFcomplexFwithFanotherFbiomoleculeFtoFexertFaFbiolog


icFeffect



LigandFBindingF-
FCORRECTFANSWERSprocessFbyFwhichFtheFligandFattachesFtoFaFspecificFreceptorFsiteFandFactivatesF


thatFreceptor,FactivatingFtheFsignalingFpathway



DimerizationF-FCORRECTFANSWERStwoFmonomersFthatFareFside-by-
sideFonFtheFsurfaceFofFtheFcellFareFpairedFandFactivatedFbyFaFligand,FwhichFcausesFaFseriesFofFsignal
s

, KinaseF-
FCORRECTFANSWERStypeFofFenzymeFthatFaddsFchemicalsFcalledFphosphatesFtoFotherFmoleculesFsu


chFasFsugarsForFproteinsFcausingFotherFmoleculesFinFtheFcellFtoFbecomeFeitherFactiveForFinactive



phosphorylationF-FCORRECTFANSWERSactivationFofFaFchemicalFprocessFtoFinitiateFsignaling



targetedFtherapiesFworkFbyFdoingFtheFfollowingF-FCORRECTFANSWERS1.FblockingFangiogenesis

2.FblockingFsignalsFinsideForFoutsideFtheFcell

3.FdeliveringFtoxicFsubstancesFtoFtheFcell

4.FstimulatingFtheFbody'sFimmuneFsystem



BCR/ABLF-FCORRECTFANSWERS-
fusionFproteinFtyrosineFkinaseFformedFwithFaFgeneFtranslocationFoccursFbetweenFgeneF9FandF22-
geneFabnormalityFcalledFtheFPhiladelphiaFchromosomeFseenFinFCMLFandFALL



VEGFF-FCORRECTFANSWERSthisFisFtheFprimaryFangiogenicFfactorFproducedFbyFcells



mTORF-FCORRECTFANSWERS-targetFofFrapamycin-
aFproteinFthatFtellsFcellsFwhenFtoFgrow,Fdivide,FandFsurvive



TwoFwaysFthatFangiogenesisFinhibitorsFworkF-
FCORRECTFANSWERS1.FsomeFintergereFwithFactionFofFVEGFFwhichFstimulatesFnFewFbloodFvesselFfor


mation2.FothersFtargetFtheirFmoleculesFthatFstimulateFnewFbloodFvesselFgrowth



SmallFMoleculeFCompoundFTargetedFTherapiesF-FCORRECTFANSWERS-endFinF-ib-
targetsFlocatedFinsideFtheFcellFbecauseFtheseFgentsFareFableFtoFenterFcellsFmoreFeasily-
intracellular-mostFgivenForally