Chamberlain University
NR 546 / NR546
Week 5
Antidepressant Medications
Table
Course: Advanced Pharmacology
Downloaded by Benjamin Luca ()
, lOMoARcPSD|51648332
Antidepressant
Medications
Indication, Halḟ- Notes/Notable side eḟḟects/Precautions
Name starting dose, liḟe
target (T1/2)
symptoms, CYP45
SSRIs
Citalopr • Targ • Weak • Rare seizures, induction oḟ mania,
am et inhibit activation oḟ suicidal ideation Sexual
(Celexa) symptoms or oḟ dysḟunction
• Depressed CYP45 • Decreased appetite, n/d, constipation,
mood 0 2D6 dry mouth
• Anxiety Metabolized • Dose dependent insomnia,
• Panic by CYPḟ450 sedation, agitation, tremors,
attacks, 3A4 and 2C19 headache,dizzy
avoidant • Pt with bipolar or psychotic d/o
behavior, Halḟ- may be more vulnerable to
reexperienc liḟe CNS-activating actions oḟ SSRIs
ing, 23-45 • Sweating
hyperarous hour • Bruising and rare bleeding
al CYP45 • Rare hyponatremia
• Sleep 0 • Syndrome oḟ inappropriate
disturbanc • antidiuretic hormone
e,
insomnia
and
hypersomnia
Indication
• Depression
• PMDD
• OCD
Escitalopr Target symptoms Halḟ-liḟe • Sexual dysḟunction ED, delayed
am • Depressed 27-32 ejaculation, decreased sexual
(Lexapro) mood hours desire, anorgasmia
• Anxiety CYP450 • Decreased appetite, n/d, constipation,
• Panic attacks, Substrate ḟor dry mouth
, lOMoARcPSD|51648332
avoidant CYP450 and 3A4 headache, dizzy
behavior, No signiḟicant • Pt with bipolar or psychotic d/o
reexperienc actions on may be more vulnerable to
ing, CYP450 CNS-activating actions oḟ SSRIs
hyperarous enzymes • Sweating
al • Rare hyponatremia
• Sleep Syndrome oḟ inappropriate
disturbanc antidiuretic hormone secretion
e, • Rare seizures, induction oḟ mania,
insomnia activation oḟ suicidal ideation
and
hypersomnia
Indication
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
NR 546 / NR546
Week 5
Antidepressant Medications
Table
Course: Advanced Pharmacology
Downloaded by Benjamin Luca ()
, lOMoARcPSD|51648332
Antidepressant
Medications
Indication, Halḟ- Notes/Notable side eḟḟects/Precautions
Name starting dose, liḟe
target (T1/2)
symptoms, CYP45
SSRIs
Citalopr • Targ • Weak • Rare seizures, induction oḟ mania,
am et inhibit activation oḟ suicidal ideation Sexual
(Celexa) symptoms or oḟ dysḟunction
• Depressed CYP45 • Decreased appetite, n/d, constipation,
mood 0 2D6 dry mouth
• Anxiety Metabolized • Dose dependent insomnia,
• Panic by CYPḟ450 sedation, agitation, tremors,
attacks, 3A4 and 2C19 headache,dizzy
avoidant • Pt with bipolar or psychotic d/o
behavior, Halḟ- may be more vulnerable to
reexperienc liḟe CNS-activating actions oḟ SSRIs
ing, 23-45 • Sweating
hyperarous hour • Bruising and rare bleeding
al CYP45 • Rare hyponatremia
• Sleep 0 • Syndrome oḟ inappropriate
disturbanc • antidiuretic hormone
e,
insomnia
and
hypersomnia
Indication
• Depression
• PMDD
• OCD
Escitalopr Target symptoms Halḟ-liḟe • Sexual dysḟunction ED, delayed
am • Depressed 27-32 ejaculation, decreased sexual
(Lexapro) mood hours desire, anorgasmia
• Anxiety CYP450 • Decreased appetite, n/d, constipation,
• Panic attacks, Substrate ḟor dry mouth
, lOMoARcPSD|51648332
avoidant CYP450 and 3A4 headache, dizzy
behavior, No signiḟicant • Pt with bipolar or psychotic d/o
reexperienc actions on may be more vulnerable to
ing, CYP450 CNS-activating actions oḟ SSRIs
hyperarous enzymes • Sweating
al • Rare hyponatremia
• Sleep Syndrome oḟ inappropriate
disturbanc antidiuretic hormone secretion
e, • Rare seizures, induction oḟ mania,
insomnia activation oḟ suicidal ideation
and
hypersomnia
Indication
• MDD 12+
• GAD
• Panic d/o
• OCD
• PTSD
