CURRENT Medical Diagnosis and
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1) Question Stem:
A 57-year-old man with a 35–pack-year smoking history asks
which screening will most reduce his lung-cancer mortality risk.
He is currently asymptomatic and in good health otherwise.
Which screening strategy is most appropriate?
,Options
A. Annual chest radiograph starting now.
B. Low-dose CT annually while the patient meets age and
smoking criteria.
C. Sputum cytology annually.
D. No screening unless symptoms develop.
Correct Answer: B
Rationales
• Correct (B): Low-dose CT screening in persons meeting age
and smoking history criteria reduces lung cancer mortality
by detecting early-stage disease amenable to curative
therapy; this is the recommended modality for eligible
high-risk smokers.
• A: Chest radiograph does not reduce lung cancer mortality
and is not recommended for screening.
• C: Sputum cytology alone has poor sensitivity for early lung
cancer and is not recommended as primary screening.
• D: Waiting for symptoms misses early-stage disease
amenable to curative treatment in high-risk individuals.
Teaching Point: Low-dose CT annually for eligible high-risk
smokers reduces lung cancer mortality.
Citation (Simplified APA): Papadakis et al. (2025). CURRENT
Medical Diagnosis & Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
,2) Question Stem:
A 28-year-old woman who plans pregnancy asks about
immunizations. She has no documentation of rubella immunity.
Which action is most appropriate now?
Options
A. Administer MMR vaccine now and advise avoidance of
pregnancy for 4 weeks.
B. Defer MMR until after pregnancy confirmation to avoid
vaccine risks.
C. Give inactivated influenza vaccine only; rubella testing later.
D. Administer varicella vaccine now because it also protects
against congenital defects.
Correct Answer: A
Rationales
• Correct (A): Nonpregnant women lacking rubella immunity
should receive MMR vaccine before conception and be
counseled to avoid pregnancy for at least 4 weeks after
vaccination.
• B: Deferring vaccination risks maternal rubella infection
during pregnancy; preconception immunization is
preferred.
• C: Influenza vaccination is recommended but does not
address rubella susceptibility; rubella immunity should be
established preconception.
, • D: Varicella vaccine prevents varicella but does not prevent
rubella; varicella also requires avoidance of pregnancy for
a period after vaccination but it’s not a substitute.
Teaching Point: Confirm and, if nonimmune, vaccinate for
rubella before conception; avoid pregnancy ≥4 weeks
afterwards.
Citation (Simplified APA): Papadakis et al. (2025). CURRENT
Medical Diagnosis & Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
3) Question Stem:
A 66-year-old woman with well-controlled hypertension asks
about colorectal cancer screening. She has never been
screened. Which approach best aligns with prevention
guidelines and life-expectancy considerations?
Options
A. No screening — she is older than the recommended age.
B. Offer colonoscopy or high-sensitivity fecal testing depending
on patient preference and ability to undergo colonoscopy.
C. Recommend only fecal occult blood testing yearly because
colonoscopy is too risky.
D. Screen with barium enema as first-line in older patients.
Correct Answer: B
Rationales
Treatment 2026
65th Edition
Author(s)Maxine A. Papadakis; Michael
W. Rabow; Kenneth R. McQuaid; Paul L.
Nadler; Erika Leemann Price
TEST BANK
1) Question Stem:
A 57-year-old man with a 35–pack-year smoking history asks
which screening will most reduce his lung-cancer mortality risk.
He is currently asymptomatic and in good health otherwise.
Which screening strategy is most appropriate?
,Options
A. Annual chest radiograph starting now.
B. Low-dose CT annually while the patient meets age and
smoking criteria.
C. Sputum cytology annually.
D. No screening unless symptoms develop.
Correct Answer: B
Rationales
• Correct (B): Low-dose CT screening in persons meeting age
and smoking history criteria reduces lung cancer mortality
by detecting early-stage disease amenable to curative
therapy; this is the recommended modality for eligible
high-risk smokers.
• A: Chest radiograph does not reduce lung cancer mortality
and is not recommended for screening.
• C: Sputum cytology alone has poor sensitivity for early lung
cancer and is not recommended as primary screening.
• D: Waiting for symptoms misses early-stage disease
amenable to curative treatment in high-risk individuals.
Teaching Point: Low-dose CT annually for eligible high-risk
smokers reduces lung cancer mortality.
Citation (Simplified APA): Papadakis et al. (2025). CURRENT
Medical Diagnosis & Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
,2) Question Stem:
A 28-year-old woman who plans pregnancy asks about
immunizations. She has no documentation of rubella immunity.
Which action is most appropriate now?
Options
A. Administer MMR vaccine now and advise avoidance of
pregnancy for 4 weeks.
B. Defer MMR until after pregnancy confirmation to avoid
vaccine risks.
C. Give inactivated influenza vaccine only; rubella testing later.
D. Administer varicella vaccine now because it also protects
against congenital defects.
Correct Answer: A
Rationales
• Correct (A): Nonpregnant women lacking rubella immunity
should receive MMR vaccine before conception and be
counseled to avoid pregnancy for at least 4 weeks after
vaccination.
• B: Deferring vaccination risks maternal rubella infection
during pregnancy; preconception immunization is
preferred.
• C: Influenza vaccination is recommended but does not
address rubella susceptibility; rubella immunity should be
established preconception.
, • D: Varicella vaccine prevents varicella but does not prevent
rubella; varicella also requires avoidance of pregnancy for
a period after vaccination but it’s not a substitute.
Teaching Point: Confirm and, if nonimmune, vaccinate for
rubella before conception; avoid pregnancy ≥4 weeks
afterwards.
Citation (Simplified APA): Papadakis et al. (2025). CURRENT
Medical Diagnosis & Treatment 2026 (65th Ed.). Ch. 1.
accessmedicine.mhmedical.com
3) Question Stem:
A 66-year-old woman with well-controlled hypertension asks
about colorectal cancer screening. She has never been
screened. Which approach best aligns with prevention
guidelines and life-expectancy considerations?
Options
A. No screening — she is older than the recommended age.
B. Offer colonoscopy or high-sensitivity fecal testing depending
on patient preference and ability to undergo colonoscopy.
C. Recommend only fecal occult blood testing yearly because
colonoscopy is too risky.
D. Screen with barium enema as first-line in older patients.
Correct Answer: B
Rationales
