BLOOD BANK ASCP STUDY GUIDE COMPREHENSIVE REVIEW WITH SOLVED SCENARIOS AND DETAILED ANSWERS ELITE EDITION 2026

BLOOD BANK ASCP STUDY GUIDE
COMPREHENSIVE REVIEW WITH SOLVED
SCENARIOS AND DETAILED ANSWERS ELITE
EDITION 2026




◉Which antibodies to a component of complement
are contained in the rabbit polyspecific antihuman
globulin reagent for detection of in vivo
sensitization?
A. Anti-IgG and anti-C3a
B. Anti-IgG and anti-C3d
C. Anti-IgG and anti-IgM
D. All of these options . Answer: In the DAT (direct antiglobulin test),
rabbit
polyspecific antisera contains both an anti-human IgG component and an
antibody against the C3d component of complement.


◉Acquired B antigens have been found in:
A. Bombay individuals
B. Group O persons

, C. All blood groups
D. Group A persons . Answer: D The acquired B phenomenon is only
seen in group A persons.


◉Blood is crossmatched on an A positive person with
a negative antibody screen. The patient received a
transfusion of A positive RBCs 3 years ago. The
donors chosen for crossmatch were A positive.
The crossmatch was run on the Ortho Provue and
yielded 3+ incompatibility. How can these results
be explained?
A. The patient has an antibody to a low-frequency
antigen
B. The patient has an antibody to a high-frequency
antigen
C. The patient is an A2 with anti-A1
D. The patient is an A1 with anti-A2 . Answer: C The patient is likely an
A2 with anti-A1 which is
causing reactivity in the crossmatch. A negative
antibody screen rules out the possibility of an
antibody to a high-frequency antigen, and two
donor units incompatible rules out an antibody to a low-frequency
antigen.