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USMLE & NCLEX Comprehensive Medical Notes – Pathophysiology, Diagnostics, and Key Concepts (Lecture Summary & Exam Review Guide)

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This document provides a complete collection of concise, high-yield medical notes covering key diseases, diagnostic tests, pharmacology, and physiology concepts essential for USMLE and NCLEX preparation. It includes comparisons (e.g., Warfarin vs Heparin, RA vs OA, restrictive vs obstructive lung disease), major syndromes, lab values, reflexes, cranial nerves, and screening guidelines. The content is structured for quick review and exam readiness, summarizing essential topics from cardiovascular, endocrine, neurological, renal, infectious, dermatologic, and psychiatric systems.

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USMLE
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USMLE

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Uploaded on
November 1, 2025
Number of pages
37
Written in
2025/2026
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USMLE & NCLEX Comprehensive Medical Notes – Pathophysiology,
Diagnostics, and Key Concepts (Lecture Summary & Exam Review
Guide)
Warfarin - -extrinsic pathway, inhibit synthesis of vit k, not in pregnancy

-Heparin - -intrinsic pathway, activate antithrombin, used in pregnancy also

-advil side effect - -renal problem, not before and after surgery (anti platelet,
so bleeding)

-hypertensive urgency vs hypertensive emergency - -emergency: end organ
damage (kidney, bleeding, brain, pupil edema , EKG)
Urgency: headache, chest pain, no end organ damage)

-confirm prostate cancer with ... - -biopsy, not PSA

-nerves related with eye movement - -3, 4, 6 so (superior oblique:4), lr
(lateral rectus:6), 3 others

-Brudzinski's Test - -for meningitis, Severe neck stiffness causes a patient's
hips and knees to flex when the neck is flexed.

-addison's sxs - -dark pigmented skin, fatigue

-cause of addison's - -def. of adrenal's hormones

-conn's syndrom - -excessive aldestrone due to adrenal tumor

-kernig's sx - -positive when the thigh is flexed at the hip and knee at 90
degree angles, and subsequent extension in the knee is painful (leading to
resistance). meningitis test

-risk factor of COPD - -smoking

-copd - -emphysema, chronic bronchitis

-obstructive pulmonary disease vs restrictive pulmonary disease - -
obstructive like asthma, restrctive like sarcoidosis

-chronic obstructive pulmonary disease - -not asthma

-uterine bleeding post menopause - -cancer

-most risk factor for osteoporosis - -smoking

,-smoking risk factor for - -COPD, AAA, osteoprosis, htn,

-atrovastatin side effect - -myalgia

-HMG coA reuctase inhibitor side effect - -myalgia

-HMG coA reuctase inhibitors - -statins

-fish oil - -decrease triglyciride not ldl

-how to increase hdl - -exercise

-when BP falls, kidney release .. - -renin

-menorrhagia vs metrohagia - -menorhagia: excessive menstruation can
cause iron def anemia
metrohagia: irregular, frequent bleeding

-sob on supine, edema of legs, fatigue - -CHF

-DVT can cause - -PE

-medication for high chlostrol - -statins

-muscle injury evaluated by ... - -MRI

-MRI for - -soft tissues: spine, brain, joint

-excessive licorice increase urinary excretion of - -potasium

-pre eclampsia+ seizure - -eclampsa

-tongue , what nerve - -12, hyopglossal for control (move) tongue
taste 7 for 2/3
9 for post 1/3

-conductive hearing loss vs sensory hearing loss - -conductive: cerumen
sensory: presbycusis

-most common site of epistaxis - -ant

-epistaxis ant vs post - -ant visible
post not visible

-most common cause of nose bleeding - -external trauma (nose picking)
kisselback's plexus

, -epistaxis tx - -nasal packing\
silver nitrate (burning)

-flat, less than 0.5 cm diameter - -

-flat - -macul
patch

-elevated, palpable - -papul
plaque

-elevated, fluid filled - -vesicle
bullae

-macul vs patch in size - -macul less than 0.5 cm
patch more than 0.5 cm

-papuls vs plaque size - -papul less than 0.5
plaque more than ‫پالک طال بزرگه‬

-vesicle vs buallae size - -vesicle less than 0.5

-psoriasis - -silvery scaly, extensors, artritis

-extensor surface vs flexor surface - -extensor (psoriasis) vs flexor (atopic
dermatitis=eczema)

-detox for acetaminophen - -NAC (N acetyl cystein)

-kayser fleischer ring - -wilson (copper overload)

-bronze pigmentation - -adison's
hematochromasis

-systemic lupus (SLE) - -butterfly rash, artritis, ANA +

-RA or OA - -rhumatoid arthritis vs osteoarthritis
morning stifness : RA:60 min OA: <30 min
RA :autoimmune, symmetry

-gout - -uric acid
meat, alcohol

-wernicke vs korsakof syndrom - -wernicke reversible
korsakof irreversible

, -wernike korsakof due to - -vit b1 (thiamin def)
due to alcohol abuse
medical emergency
tx: thiamin

-wernike encephalopathy - -ataxia, confusion, Ophthalmoplegia( paralysis or
weakness of the eye muscles)

-korsakof psychosis (amnesia) - -confabulation, impaired short term memory

-nerve 1 - -olfactory (smell) sensory

-nerve 12 - -tongue (hypoglossal), movement

-nerve 2 - -optic, sensory

-3, 4, 6 - -pure motor

-oculumotor - -3

-trochlear - -nerve 4

-nerve 5 how many branches
nerve 7 how many branches - -5 3 branches
7 5 branches

-abducent - -6

-oculomotor - -3

-vestibulocochlear - -8

-semicircular canals+cochlear - -semicircuar for balance
cochlear for hearing
both are sensory

-glosopharengial - -9 both sensory and motor

-vagus - -10 both s and m
connect most of organs: ht, lu, sp, kd, clon, st, lv, parasympathic
taste valecella, epiglot)

-accessory - -11 , SCM, trapezius motor

-cranial nerves (pure motor) - -3,4,6,11,12

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