Harrison's Principles of Internal Medicine (Vol.1
& Vol.2)
21st Edition Newer Edition
Author(s)Joseph Loscalzo; Anthony S. Fauci;
Dennis L. Kasper; Stephen Hauser; Dan Longo; J.
Larry Jameson
TEST BANK
1) Reference
Ch. 1 — The Practice of Medicine
Question Stem: A 68-year-old man with multiple chronic
conditions asks whether to stop one of his three daily
medications to simplify his regimen. Which approach best aligns
with high-value, patient-centered practice?
,A. Automatically discontinue the oldest medication to simplify
the regimen.
B. Use shared decision-making to discuss risks, benefits, and
patient goals.
C. Continue all medications because polypharmacy reduces
relapse risk.
D. Replace all current medications with a single broad-spectrum
agent.
Correct Answer: B
Rationales:
• Correct (B): Shared decision-making aligns care with the
patient's goals and balances benefits/harms, central to
high-quality practice.
• A: Discontinuing the oldest drug without evaluating
indication risks harm and disregards individualized
assessment.
• C: Polypharmacy often increases adverse events;
continuation without reassessment is not evidence-based.
• D: Replacing multiple targeted agents with one nonspecific
drug risks therapeutic failure and increased adverse
effects.
Teaching Point: Shared decision-making personalizes treatment
by balancing benefits, harms, and patient goals.
,Citation: Loscalzo et al. (2022). Harrison’s Principles of Internal
Medicine (21st Ed.). Ch. 1.
2) Reference
Ch. 2 — Promoting Good Health
Question Stem: A primary-care clinic wants to increase smoking
cessation in its adult patients. Which intervention is most likely
to produce population-level health benefit?
A. Providing brief clinician advice plus referral to cessation
resources.
B. Waiting for patients to request help before offering
interventions.
C. Only distributing printed brochures in the waiting room.
D. Recommending electronic cigarettes to all smokers.
Correct Answer: A
Rationales:
• Correct (A): Brief clinician advice with active referral
increases quit rates and is scalable for population health.
• B: Passive approaches miss many patients; proactive offers
are more effective.
• C: Passive materials alone have limited effectiveness
without active engagement.
, • D: Recommending e-cigarettes universally lacks definitive
evidence and may cause harm.
Teaching Point: Brief clinician advice plus active referral
increases smoking cessation success.
Citation: Loscalzo et al. (2022). Harrison’s Principles of Internal
Medicine (21st Ed.). Ch. 2.
3) Reference
Ch. 3 — Vaccine Opposition and Hesitancy
Question Stem: A parent refuses MMR vaccination citing safety
concerns. Which clinician response best reduces hesitancy
while maintaining trust?
A. Dismiss the parent's concerns and insist on vaccination
immediately.
B. Provide empathetic listening, acknowledge concerns, and
offer clear risk-benefit information.
C. Passive acceptance and do not revisit the topic.
D. Threaten legal action to force vaccination.
Correct Answer: B
Rationales:
• Correct (B): Empathic dialogue and clear risk-benefit
framing improve trust and uptake.
& Vol.2)
21st Edition Newer Edition
Author(s)Joseph Loscalzo; Anthony S. Fauci;
Dennis L. Kasper; Stephen Hauser; Dan Longo; J.
Larry Jameson
TEST BANK
1) Reference
Ch. 1 — The Practice of Medicine
Question Stem: A 68-year-old man with multiple chronic
conditions asks whether to stop one of his three daily
medications to simplify his regimen. Which approach best aligns
with high-value, patient-centered practice?
,A. Automatically discontinue the oldest medication to simplify
the regimen.
B. Use shared decision-making to discuss risks, benefits, and
patient goals.
C. Continue all medications because polypharmacy reduces
relapse risk.
D. Replace all current medications with a single broad-spectrum
agent.
Correct Answer: B
Rationales:
• Correct (B): Shared decision-making aligns care with the
patient's goals and balances benefits/harms, central to
high-quality practice.
• A: Discontinuing the oldest drug without evaluating
indication risks harm and disregards individualized
assessment.
• C: Polypharmacy often increases adverse events;
continuation without reassessment is not evidence-based.
• D: Replacing multiple targeted agents with one nonspecific
drug risks therapeutic failure and increased adverse
effects.
Teaching Point: Shared decision-making personalizes treatment
by balancing benefits, harms, and patient goals.
,Citation: Loscalzo et al. (2022). Harrison’s Principles of Internal
Medicine (21st Ed.). Ch. 1.
2) Reference
Ch. 2 — Promoting Good Health
Question Stem: A primary-care clinic wants to increase smoking
cessation in its adult patients. Which intervention is most likely
to produce population-level health benefit?
A. Providing brief clinician advice plus referral to cessation
resources.
B. Waiting for patients to request help before offering
interventions.
C. Only distributing printed brochures in the waiting room.
D. Recommending electronic cigarettes to all smokers.
Correct Answer: A
Rationales:
• Correct (A): Brief clinician advice with active referral
increases quit rates and is scalable for population health.
• B: Passive approaches miss many patients; proactive offers
are more effective.
• C: Passive materials alone have limited effectiveness
without active engagement.
, • D: Recommending e-cigarettes universally lacks definitive
evidence and may cause harm.
Teaching Point: Brief clinician advice plus active referral
increases smoking cessation success.
Citation: Loscalzo et al. (2022). Harrison’s Principles of Internal
Medicine (21st Ed.). Ch. 2.
3) Reference
Ch. 3 — Vaccine Opposition and Hesitancy
Question Stem: A parent refuses MMR vaccination citing safety
concerns. Which clinician response best reduces hesitancy
while maintaining trust?
A. Dismiss the parent's concerns and insist on vaccination
immediately.
B. Provide empathetic listening, acknowledge concerns, and
offer clear risk-benefit information.
C. Passive acceptance and do not revisit the topic.
D. Threaten legal action to force vaccination.
Correct Answer: B
Rationales:
• Correct (B): Empathic dialogue and clear risk-benefit
framing improve trust and uptake.
