Asthma KSA Questions and Correct Answers
Asthma: symptoms <2x/ week, nocturnal symptoms <2x month
Ans: Mild Intermittent asthma, FEV1 >80%
Asthma: symptoms >2x/ week but not daily, nocturnal symptoms
>2x month, Ans: Mild persistent asthma, FEV1 >80%
Asthma: daily symptoms, daily SABA use, nocturnal symptoms >2x
month Ans: Moderate persistent asthma, FEV1 60-80%
Asthma: Continuous symptoms, limits activity, frequent nocturnal
symptoms Ans: Severe persistent, FEV1 <60%
spirometry changes in asthma Ans: FEV1 < 80%, post SABA FEV1
increase by 12% and 200 mL
Inflammatory Mediators of asthma Ans: Interleukins 4 and 5
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GM-CSF
Interferon Gamma
TNF alpha
Leukotriene C4
Histamine
Irreversible airway changes in asthma Ans: Goblet cell
hyperplasia
Microvascular proliferation
Sub-epithelial collagen deposition
Smooth muscle hypertrophy
Risk factor for developing persistent asthma in children <3 yrs old
Ans: Parental asthma
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Hx of atopic dermatitis
Sensitization to aeroantigens
Eosinophilia >4%
Wheezing apart from colds
Food allergy
Early Spring environmental allergy Ans: Tree
Late Spring environmental allergy Ans: Grass
Late Summer/Early Fall environmental allergy Ans: weed
Summer and Fall environmental allergy Ans: Alternaria,
Cladosporium, and mites
Agent most commonly used in bronchoprovocation testing Ans:
Methacholine
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