PAST 421 - Pharm Challenge Questions - Exam 1
Questions with Detailed Verified Answers
A teenager seeks postcoital contraception. Which of the following preparations will
be effective for this purpose?
(A) Clomiphene
(B) Ethinyl estradiol
(C) Diethylstilbestrol (DES)
(D) Mifepristone
(E) Norgestrel Ans: (D) Mifepristone
A 23-year-old woman desires a combined oral contraceptive for pregnancy protection.
Which of the following patient factors would lead a health professional to recommend
an alternative form of contraception?
(A) Evidence of hirsutism
(B) History of gastroesophageal reflux disease and is currently taking omeprazole
(C) History of pelvic inflammatory disease
(D) History of migraine headache that is well controlled by sumatriptan
(E) She plans to use this contraceptive for about 1 yr and will then attempt to become
pregnant Ans: (D) History of migraine headache that is well controlled by sumatriptan
,Men who use large doses of anabolic steroids are at increased risk of which of the
following?
(A) Anemia
(B) Cholestatic jaundice and elevation of aspartate transaminase levels in the blood
(C) Hirsutism
(D) Hyperprolactinemia
(E) Testicular enlargement Ans: (B) Cholestatic jaundice and elevation of aspartate
transaminase levels in the blood
A 50-year-old woman with a positive mammogram undergoes lumpectomy and a small
carcinoma is removed. Biochemical analysis of the cancer reveals the presence of
estrogen and progesterone receptors. After this procedure, she will probably receive
which of the following drugs?
(A) Danazol
(B) Flutamide
(C) Leuprolide
(D) Mifepristone
(E) Tamoxifen Ans: (E) Tamoxifen
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,A 60-year-old man is found to have a prostate lump and an elevated prostate-specific
antigen (PSA) blood test. Magnetic resonance imaging suggests several enlarged lymph
nodes in the lower abdomen, and an x-ray reveals 2 radiolucent lesions in the bony
pelvis. This patient is likely to be treated with which of the following drugs?
(A) Anastrozole
(B) Desogestrel
(C) Leuprolide
(D) Methyltestosterone
(E) Oxandrolone Ans: (C) Leuprolide
A young woman complains of abdominal pain at the time of menstruation. Careful
evaluation indicates the presence of significant endometrial deposits on the pelvic
peritoneum. Which of the following is the most appropriate medical therapy for this
patient?
(A) Flutamide, orally
(B) Medroxyprogesterone acetate by intramuscular injection
(C) Norgestrel as an IUD
(D) Oxandrolone by intramuscular injection
(E) Raloxifene orally Ans: (B) Medroxyprogesterone acetate by intramuscular injection
Diethylstilbestrol (DES) should never be used in pregnant women because it is
associated with which of the following?
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, (A) Deep vein thrombosis
(B) Feminization of the external genitalia of male offspring
(C) Infertility and development of vaginal cancer in female offspring
(D) Miscarriages
(E) Virilization of the external genitalia of female offspring Ans: (C) Infertility and
development of vaginal cancer in female offspring
Which of the following is a unique property of SERMs?
(A) Act as agonists in some tissues and antagonists in other tissues
(B) Activate a unique plasma membrane-bound receptor
(C) Have both estrogenic and progestational agonist activity
(D) Inhibit the aromatase enzyme required for estrogen synthesis
(E) Produce estrogenic effects without binding to estrogen receptors Ans: (A) Act as
agonists in some tissues and antagonists in other tissues
Finasteride has efficacy in the prevention of male-pattern baldness by virtue of its
ability to do which of the following?
(A) Competitively antagonize androgen receptors
(B) Decrease the release of gonadotropins
© Get it right 2025 Getaway - Stuvia US All rights reserved
Questions with Detailed Verified Answers
A teenager seeks postcoital contraception. Which of the following preparations will
be effective for this purpose?
(A) Clomiphene
(B) Ethinyl estradiol
(C) Diethylstilbestrol (DES)
(D) Mifepristone
(E) Norgestrel Ans: (D) Mifepristone
A 23-year-old woman desires a combined oral contraceptive for pregnancy protection.
Which of the following patient factors would lead a health professional to recommend
an alternative form of contraception?
(A) Evidence of hirsutism
(B) History of gastroesophageal reflux disease and is currently taking omeprazole
(C) History of pelvic inflammatory disease
(D) History of migraine headache that is well controlled by sumatriptan
(E) She plans to use this contraceptive for about 1 yr and will then attempt to become
pregnant Ans: (D) History of migraine headache that is well controlled by sumatriptan
,Men who use large doses of anabolic steroids are at increased risk of which of the
following?
(A) Anemia
(B) Cholestatic jaundice and elevation of aspartate transaminase levels in the blood
(C) Hirsutism
(D) Hyperprolactinemia
(E) Testicular enlargement Ans: (B) Cholestatic jaundice and elevation of aspartate
transaminase levels in the blood
A 50-year-old woman with a positive mammogram undergoes lumpectomy and a small
carcinoma is removed. Biochemical analysis of the cancer reveals the presence of
estrogen and progesterone receptors. After this procedure, she will probably receive
which of the following drugs?
(A) Danazol
(B) Flutamide
(C) Leuprolide
(D) Mifepristone
(E) Tamoxifen Ans: (E) Tamoxifen
© Get it right 2025 Getaway - Stuvia US All rights reserved
,A 60-year-old man is found to have a prostate lump and an elevated prostate-specific
antigen (PSA) blood test. Magnetic resonance imaging suggests several enlarged lymph
nodes in the lower abdomen, and an x-ray reveals 2 radiolucent lesions in the bony
pelvis. This patient is likely to be treated with which of the following drugs?
(A) Anastrozole
(B) Desogestrel
(C) Leuprolide
(D) Methyltestosterone
(E) Oxandrolone Ans: (C) Leuprolide
A young woman complains of abdominal pain at the time of menstruation. Careful
evaluation indicates the presence of significant endometrial deposits on the pelvic
peritoneum. Which of the following is the most appropriate medical therapy for this
patient?
(A) Flutamide, orally
(B) Medroxyprogesterone acetate by intramuscular injection
(C) Norgestrel as an IUD
(D) Oxandrolone by intramuscular injection
(E) Raloxifene orally Ans: (B) Medroxyprogesterone acetate by intramuscular injection
Diethylstilbestrol (DES) should never be used in pregnant women because it is
associated with which of the following?
© Get it right 2025 Getaway - Stuvia US All rights reserved
, (A) Deep vein thrombosis
(B) Feminization of the external genitalia of male offspring
(C) Infertility and development of vaginal cancer in female offspring
(D) Miscarriages
(E) Virilization of the external genitalia of female offspring Ans: (C) Infertility and
development of vaginal cancer in female offspring
Which of the following is a unique property of SERMs?
(A) Act as agonists in some tissues and antagonists in other tissues
(B) Activate a unique plasma membrane-bound receptor
(C) Have both estrogenic and progestational agonist activity
(D) Inhibit the aromatase enzyme required for estrogen synthesis
(E) Produce estrogenic effects without binding to estrogen receptors Ans: (A) Act as
agonists in some tissues and antagonists in other tissues
Finasteride has efficacy in the prevention of male-pattern baldness by virtue of its
ability to do which of the following?
(A) Competitively antagonize androgen receptors
(B) Decrease the release of gonadotropins
© Get it right 2025 Getaway - Stuvia US All rights reserved
