Page |1
WGU D116 ADVANCED PHARMACOLOGY OA AND PRE
ASSESSMENT 2025/2026 NEWEST ACTUAL EXAM WITH
COMPLETE QUESTIONS AND VERIFIED ANSWERS
|ALREADY GRADED A+|
A patient is taking oral ketoconazole for a systemic fungal
infection. The nurse reviews the medication administration record
and notes that the patient is also taking omeprazole for reflux
disease.
What action should the nurse take? - ANSWERS-YES Administer
the omeprazole at least two hours after the ketoconazole
Confer with the prescriber about a potential hazardous interaction
Do not administer omeprazole to a patient receiving ketoconazole
Administer the omeprazole one hour before the ketoconazole
Correct! The nurse should administer the omeprazole at least two
hours after the ketoconazole to prevent a drug-to-drug interaction.
A patient who is taking acetaminophen for pain wants to know
why it does not cause gastrointestinal upset as other over-the-
counter pain medications do.
, Page |2
Which property of acetaminophen is the most likely explanation
for this? - ANSWERS-YES It has minimal effects at peripheral
sites.
NO It does not inhibit cyclooxygenase.
It is more similar to opioids than to nonsteroidal anti-inflammatory
drugs (NSAIDs).
NO It is selective for cyclooxygenase-2.
Incorrect. Acetaminophen is not selective for cyclooxygenase-2
(COX-2). Incorrect. Acetaminophen is a selective cyclooxygenase
(COX) inhibitor. Correct! The differences between the effects of
acetaminophen and aspirin are thought to result from selective
inhibition of cyclooxygenase. Acetaminophen has only minimal
effects on cyclooxygenase at peripheral sites, which may explain
why acetaminophen does not have adverse GI, renal, and
antiplatelet effects.
A patient who has arthritis has been taking ibuprofen and a
glucocorticoid medication. The patient reports having tarry stools
but denies gastric pain.
Which action by the provider is correct? - ANSWERS-Counseling
the patient to use over-the-counter (OTC) antacids
, Page |3
Reassuring the patient not to worry unless there is gastric pain
YES Prescribing an antiulcer medication
Telling the patient to stop taking the glucocorticoid immediately
Correct! Glucocorticoid therapy, especially when combined with
NSAIDs, can increase the risk of gastric ulcer and possibly GI
bleeding.
A patient will begin taking hydroxychloroquine for rheumatoid
arthritis. The patient is currently taking high-dose NSAIDs and
methotrexate.
What should the patient be taught about hydroxychloroquine? -
ANSWERS-The dose of NSAIDs may be decreased when
beginning hydroxychloroquine.
The patient should stop taking methotrexate when starting
hydroxychloroquine.
YES An eye examination is necessary at the beginning of therapy
with this drug.
NO It is important to obtain tests of renal and hepatic function
while the patient is taking this drug.
Incorrect. Renal and hepatic toxicity are not concerns.
, Page |4
Correct! Hydroxychloroquine can cause retinal damage, so an
eye examination is necessary at the onset of treatment as well as
every six months during treatment.
A patient with gout who has increasingly frequent acute gouty
attacks will begin receiving allopurinol and colchicine.
Which statement should be included when teaching the patient
about this drug regimen? - ANSWERS-"Allopurinol reduces the
likelihood of gouty episodes that usually occur with initial
colchicine therapy."
NO "Colchicine is given to enhance the effects of allopurinol."
"Allopurinol helps reduce the gastrointestinal side effects of
colchicine."
YES "You will take both drugs initially and then stop taking
colchicine."
Incorrect. Colchicine does not enhance the effects of allopurinol.
Correct! Colchicine is used for prophylaxis when urate-lowering
drugs, such as allopurinol, are initiated because gouty episodes
often increase during this time. Patients start with both drugs and
ultimately withdraw the colchicine.
WGU D116 ADVANCED PHARMACOLOGY OA AND PRE
ASSESSMENT 2025/2026 NEWEST ACTUAL EXAM WITH
COMPLETE QUESTIONS AND VERIFIED ANSWERS
|ALREADY GRADED A+|
A patient is taking oral ketoconazole for a systemic fungal
infection. The nurse reviews the medication administration record
and notes that the patient is also taking omeprazole for reflux
disease.
What action should the nurse take? - ANSWERS-YES Administer
the omeprazole at least two hours after the ketoconazole
Confer with the prescriber about a potential hazardous interaction
Do not administer omeprazole to a patient receiving ketoconazole
Administer the omeprazole one hour before the ketoconazole
Correct! The nurse should administer the omeprazole at least two
hours after the ketoconazole to prevent a drug-to-drug interaction.
A patient who is taking acetaminophen for pain wants to know
why it does not cause gastrointestinal upset as other over-the-
counter pain medications do.
, Page |2
Which property of acetaminophen is the most likely explanation
for this? - ANSWERS-YES It has minimal effects at peripheral
sites.
NO It does not inhibit cyclooxygenase.
It is more similar to opioids than to nonsteroidal anti-inflammatory
drugs (NSAIDs).
NO It is selective for cyclooxygenase-2.
Incorrect. Acetaminophen is not selective for cyclooxygenase-2
(COX-2). Incorrect. Acetaminophen is a selective cyclooxygenase
(COX) inhibitor. Correct! The differences between the effects of
acetaminophen and aspirin are thought to result from selective
inhibition of cyclooxygenase. Acetaminophen has only minimal
effects on cyclooxygenase at peripheral sites, which may explain
why acetaminophen does not have adverse GI, renal, and
antiplatelet effects.
A patient who has arthritis has been taking ibuprofen and a
glucocorticoid medication. The patient reports having tarry stools
but denies gastric pain.
Which action by the provider is correct? - ANSWERS-Counseling
the patient to use over-the-counter (OTC) antacids
, Page |3
Reassuring the patient not to worry unless there is gastric pain
YES Prescribing an antiulcer medication
Telling the patient to stop taking the glucocorticoid immediately
Correct! Glucocorticoid therapy, especially when combined with
NSAIDs, can increase the risk of gastric ulcer and possibly GI
bleeding.
A patient will begin taking hydroxychloroquine for rheumatoid
arthritis. The patient is currently taking high-dose NSAIDs and
methotrexate.
What should the patient be taught about hydroxychloroquine? -
ANSWERS-The dose of NSAIDs may be decreased when
beginning hydroxychloroquine.
The patient should stop taking methotrexate when starting
hydroxychloroquine.
YES An eye examination is necessary at the beginning of therapy
with this drug.
NO It is important to obtain tests of renal and hepatic function
while the patient is taking this drug.
Incorrect. Renal and hepatic toxicity are not concerns.
, Page |4
Correct! Hydroxychloroquine can cause retinal damage, so an
eye examination is necessary at the onset of treatment as well as
every six months during treatment.
A patient with gout who has increasingly frequent acute gouty
attacks will begin receiving allopurinol and colchicine.
Which statement should be included when teaching the patient
about this drug regimen? - ANSWERS-"Allopurinol reduces the
likelihood of gouty episodes that usually occur with initial
colchicine therapy."
NO "Colchicine is given to enhance the effects of allopurinol."
"Allopurinol helps reduce the gastrointestinal side effects of
colchicine."
YES "You will take both drugs initially and then stop taking
colchicine."
Incorrect. Colchicine does not enhance the effects of allopurinol.
Correct! Colchicine is used for prophylaxis when urate-lowering
drugs, such as allopurinol, are initiated because gouty episodes
often increase during this time. Patients start with both drugs and
ultimately withdraw the colchicine.
