ONS FUNDAMENTALS OF CHEMOTHERAPY IMMUNOTHERAPY ADMIN EXAM QUESTIONS AND ANSWERS 100% CORRECT!!

induction - ANSWER initial phase of hematologic malignancies such as leukemia usually in the hospital b/c of serious SE and potential complications from the intended myelosuppresion. Goal is to achieve complete response why do consolidation (after induction)? - ANSWER to ensure treatment takes effect and ↓ reoccurrence. Treatment is vital bc leukemic cells that are not clinically apparent (via CBC, BMB) are almost always still present in the bone marrow what is myeloablation - ANSWER bone marrow is obliterated by chemo or radiation why do myeloablation - ANSWER to prepare for peripheral blood stem cell transplant or bone marrow transplant myeloablation is often used to treat - ANSWER blood malignancies such as leukemia or lymphoma True/False - combination therapy has been shown to increase survival over monotherapy - ANSWER TRUE, but MOA is not fully understood (Olsen, 2019) reasons combo chemo therapy thought to work better - ANSWER 1 - ↓ likelihood of drug resistance bc diff MOA in diff drugs 2 - cancer cells usually heterogeneous; diff MOA of chemos ↑amount of cancer cells killed at one time 3 - multiple chemos provide synergistic effect (one drug helps another work better) [leucovorin and 5-fluorouracil treating colon cancer] [leucovorin increases deadly effect that 5-fluorouracil has on cancer; cytotoxicity is potentiated] how to measure response to treatment - ANSWER - surgical exam/