APHON PRINCIPLES OF BIOTHERAPY EXAM
QUESTIONS AND ANSWERS 100% CORRECT!!
, biotherapy - ANSWER modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - ANSWER tumor cells express abnormal tumor antigens on
surface that can be recognized/destroyed by immune system
natural killer cells - ANSWER lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - ANSWER recognize tumor-assosiated antigens and kills cells
interferons - ANSWER multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines - ANSWER products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon - ANSWER leukocyte-derived. tx: hairy cell leukemia, melanoma,
chronic myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - ANSWER fibroblast-derived. tx MS
gamma-interferon - ANSWER t-lymphocyte derived. tx chronic granulomatus disease
interleukin-2 - ANSWER produced by t-helper cells & stimulate growth/maturation of t-
cell subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - ANSWER immunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra) - ANSWER tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - ANSWER retinoid tx neuroblastoma.
QUESTIONS AND ANSWERS 100% CORRECT!!
, biotherapy - ANSWER modality of tx: agents that resemble body's own defense and
surveillance systems. can augment/modulate/restore host's immune response, direct
antitumor activity, other biological effects. side effects typically hypersensitivity rx
immune surveillance - ANSWER tumor cells express abnormal tumor antigens on
surface that can be recognized/destroyed by immune system
natural killer cells - ANSWER lymphocyte that recognizes/kills malignant cells
cytotoxic t cells - ANSWER recognize tumor-assosiated antigens and kills cells
interferons - ANSWER multiple moa's & produced w/ recombinant dna.
protein capable of protecting other cells from viral infections by interfering w/ viral
replication.
family of glycoproteins include: antiviral, antiproliferative, potent immunomodulatory
effects
cytokines - ANSWER products of immune cells to enhance cytotoxic activity of cells and
increase immune response
alpha-interferon - ANSWER leukocyte-derived. tx: hairy cell leukemia, melanoma,
chronic myeloid leukemia, follicular lymphoma, multiple myeloma, cutaneous t-cell
lymphoma
beta-interferon - ANSWER fibroblast-derived. tx MS
gamma-interferon - ANSWER t-lymphocyte derived. tx chronic granulomatus disease
interleukin-2 - ANSWER produced by t-helper cells & stimulate growth/maturation of t-
cell subsets, cytotoxic t-cells, production of lymphokines & cytokines.
act as chemical signals b/w wbc's (revs up immune system)
retinoids - ANSWER immunomodulators that facilitate differentiation & suppress
proliferation of cancer cells
all-trans retinoic acid (atra) - ANSWER tx: aml, aml m3 subtype, apl
increase maturation of promyelocytic blasts and rapid resolution of coagulopathy r/t tx.
isotretinoin (accutane) - ANSWER retinoid tx neuroblastoma.
