Adv. Pharm NURS 8024 Week 1 exam with answers

Adv. Pharm NURS 8024 Week 1 exam with
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answers
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Pharmacokinetics - CORRECT ANSWERS ✔✔what the body does |\ |\ |\ |\ |\ |\ |\ |\


to the drug
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Pharmacodynamics - CORRECT ANSWERS ✔✔what the drug does |\ |\ |\ |\ |\ |\ |\ |\


to the body
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Toxicology - CORRECT ANSWERS ✔✔The undesirable effects of
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chemicals on living systems |\ |\ |\




Pharmacotherapeutics - CORRECT ANSWERS ✔✔dynamic that |\ |\ |\ |\ |\ |\


achieves the desired therapeutic effect of the drug without
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causing other undesirable effects
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Legend drugs - CORRECT ANSWERS ✔✔another name for
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prescription drugs |\




Pharmacogenomics - CORRECT ANSWERS ✔✔the study of |\ |\ |\ |\ |\ |\ |\


genetically determined variations in the response to drugs
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Pharmacologic Agonist - CORRECT ANSWERS ✔✔agent binds to |\ |\ |\ |\ |\ |\ |\ |\


and activates the
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receptor - directly or indirectly causing an effect, full or partial
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agonists

,Pharmacological Antagonist - CORRECT ANSWERS ✔✔Agent binds |\ |\ |\ |\ |\ |\


to receptor-completes with other molecules and prevents binding
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by other molecules-it inhibits other molecules from binding
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Pro-drug - CORRECT ANSWERS ✔✔An inactive percursor
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chemical-must be abosorbed and distributed and converted to |\ |\ |\ |\ |\ |\ |\ |\


the active form of the drug by biologic processes.
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What is ADME? - CORRECT ANSWERS ✔✔Absorption
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Distribution
Metabolism
Elimination


Absorption - CORRECT ANSWERS ✔✔entry of pharmacologic
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agent into plasma |\ |\




Distribution - CORRECT ANSWERS ✔✔agent leaves the |\ |\ |\ |\ |\ |\ |\


bloodstream and distributes to interstitial and intracellular fluids
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Metablosim - CORRECT ANSWERS ✔✔chemical processes that |\ |\ |\ |\ |\ |\ |\


occur to make the drug useful in the bloodstream--done by the
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liver, kidney, or other tissue
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Ellimination - CORRECT ANSWERS ✔✔Leaving the body-via urine,
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bile, feces, lungs, sweat, breast milk
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, 2 Major Administration Routes - CORRECT ANSWERS ✔✔1. Enteral
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-most common, easy, cheap-BUT drug absorption pathways can
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be complicated |\




2. Parenteral-IV, fast, more expensive, once in-cannot get back
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Enteral drug administration - CORRECT ANSWERS ✔✔oral,
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sublingual, rectal |\




drug absorption pathways complicated
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**First-pass metabolism can limit the amount of drug that enters |\ |\ |\ |\ |\ |\ |\ |\ |\ |\


systemic circulation |\




influenced by food and other drugs |\ |\ |\ |\ |\




What is first pass metabolism? - CORRECT ANSWERS ✔✔The
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concentration of drug is greatly reduced BEFORE reaching |\ |\ |\ |\ |\ |\ |\ |\


systemic circulation. This mainly involves liver enzymes, but also
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includes gastric enzymes, gut wall enzymes, and bacterial
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enzymes. Bioavaliability is reduced. |\ |\ |\




https://www.youtube.com/watch?v=BQQns7RAUzA


Parenteral drug administration - CORRECT ANSWERS ✔✔-IV, IM, |\ |\ |\ |\ |\ |\ |\ |\


SubQ
- More control over actual dose of drug
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- Directly into systemic circulation-bypass first pass metabolism
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- used for drugs poorly absorbed by GI
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-Rapid onset of action |\ |\ |\




-Disadvantage: cannot take the drug back, infection risk |\ |\ |\ |\ |\ |\ |\