PNB Exam III – Questions & answers
rated A+ updated to pass
Which of the following will increase smooth muscle contraction?
A. More Ca2+ binds to troponin
B. Increase cAMP level
C. Apply M2 receptor antagonist
D. Activate Myosin Light Chain Kinase
E. Activate phosphatase - ANS ✔✔D. Activate Myosin Light Chain Kinase
(Remember: Smooth muscle does not have troponin, it only has myosin light chain kinase.)
Which of the following mechanism will inhibit HCl secretion?
A. M3 receptor Agonist
B. H2 receptor Agonist
C. Activation of Gi-coupled receptor
D. Activation of Gq-coupled receptor - ANS ✔✔C. Activation of Gi-coupled receptor
A drug that blocks the fusion of tubulovesicular membrane and intracellular canaliculus in
parietal cells would result in...
A. an increased production of HCl.
B. an increased production of pepsinogen by chief cells.
C. an increased protein digestion in the stomach.
D. a decreased somatostatin production.
E. an increased catlytic activity of pepsin. - ANS ✔✔D. a decreased somatostatin production.
, Compared with a normal animal, a genetically knockout mouse, which lacks the hormone
secretin, which of the following would be expected to be increased in the mutant mouse?
A. pH of pancreatic ductular secretion
B. volume of pancreatic secretion
C. pH of duodenal contents
D. susceptibility to duodenal erosions and ulcerations
E. gallbladder contractibility - ANS ✔✔D. susceptibility to duodenal erosions and ulcerations
In Hartnup disease (a defect in the transport of neutral amino acid), patients do not become
deficient in these amino acids due to the activity of
A. PepT1
B. Brush border peptidases
C. Na,K ATPase
D. trpsin
E. CFTR - ANS ✔✔A. PepT1
C is too general to answer the question because C is required in every step. You can bring in
dipeptides and tripeptides via PepT1 and then break them down into the neutral amino acid via
exopeptidases you need.
Which of the following symptoms are likely seen in severe hepatitis patients?
1. Increased clotting time
2. Weight loss
3. Portal hypertension and ascites
rated A+ updated to pass
Which of the following will increase smooth muscle contraction?
A. More Ca2+ binds to troponin
B. Increase cAMP level
C. Apply M2 receptor antagonist
D. Activate Myosin Light Chain Kinase
E. Activate phosphatase - ANS ✔✔D. Activate Myosin Light Chain Kinase
(Remember: Smooth muscle does not have troponin, it only has myosin light chain kinase.)
Which of the following mechanism will inhibit HCl secretion?
A. M3 receptor Agonist
B. H2 receptor Agonist
C. Activation of Gi-coupled receptor
D. Activation of Gq-coupled receptor - ANS ✔✔C. Activation of Gi-coupled receptor
A drug that blocks the fusion of tubulovesicular membrane and intracellular canaliculus in
parietal cells would result in...
A. an increased production of HCl.
B. an increased production of pepsinogen by chief cells.
C. an increased protein digestion in the stomach.
D. a decreased somatostatin production.
E. an increased catlytic activity of pepsin. - ANS ✔✔D. a decreased somatostatin production.
, Compared with a normal animal, a genetically knockout mouse, which lacks the hormone
secretin, which of the following would be expected to be increased in the mutant mouse?
A. pH of pancreatic ductular secretion
B. volume of pancreatic secretion
C. pH of duodenal contents
D. susceptibility to duodenal erosions and ulcerations
E. gallbladder contractibility - ANS ✔✔D. susceptibility to duodenal erosions and ulcerations
In Hartnup disease (a defect in the transport of neutral amino acid), patients do not become
deficient in these amino acids due to the activity of
A. PepT1
B. Brush border peptidases
C. Na,K ATPase
D. trpsin
E. CFTR - ANS ✔✔A. PepT1
C is too general to answer the question because C is required in every step. You can bring in
dipeptides and tripeptides via PepT1 and then break them down into the neutral amino acid via
exopeptidases you need.
Which of the following symptoms are likely seen in severe hepatitis patients?
1. Increased clotting time
2. Weight loss
3. Portal hypertension and ascites
