PHARMACIST-LEVEL KNOWLEDGE: HESI RN PHARMACOLOGY Q-BANK (2025) – 100+ Verified Questions with Deep Rationales

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HESI RN Pharmacology Q-Bank –LATEST 2025–2026 Edition

Verified Questions with Detailed Rationales

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📘 Document Type:

Question Bank for HESI RN Students

📅 Updated:

2025–2026 Academic Year

📚 Includes:

 100+ Pharmacology Practice Questions

 NCLEX/HESI-Style Format

 Multiple Choice, SATA & Clinical Judgment

 Verified Correct Answers

 Detailed Answer Rationales

💼 Best Used For:

HESI RN Pharmacology Prep | NCLEX Review | Nursing Exam Success

🧠 Created by:

HealthStudyPro

Helping Nursing Students Pass with Confidence

📧 Email:

📲 WhatsApp: +254727526142

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Welcome to the HESI RN Pharmacology Q-Bank (2025–2026 Edition), created by
HealthStudyPro to support nursing students preparing for the HESI exit exam and NCLEX-RN
with focused, high-yield pharmacology practice.

This question bank includes 100+ carefully selected questions, designed in the HESI exam
style, covering critical pharmacology concepts tested in real clinical settings. Each question is
followed by a correct answer and a brief but thorough rationale to help you not just
memorize, but understand the “why” behind each answer.

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Question 1

A nurse is administering furosemide (Lasix) to a client with heart failure. Which electrolyte
imbalance should the nurse monitor most closely?

A. Hyperkalemia
B. Hypokalemia ✅
C. Hypernatremia
D. Hypocalcemia

✅ Correct Answer: B. Hypokalemia

🧠 Rationale:
Furosemide is a loop diuretic that causes potassium excretion. The nurse should monitor for
hypokalemia, which can cause muscle cramps, weakness, or cardiac dysrhythmias.



Question 2

A client is prescribed warfarin (Coumadin). Which of the following instructions is most
important for the nurse to include?

A. Avoid green leafy vegetables entirely
B. Report signs of bleeding ✅
C. Take with antacids to prevent stomach upset
D. Expect your urine to turn orange

✅ Correct Answer: B. Report signs of bleeding

🧠 Rationale:
Warfarin is an anticoagulant. Patients should be instructed to watch for signs of bleeding
(bruising, gum bleeding, black stools). Vitamin K intake should be consistent, not eliminated.



Question 3

A nurse is reviewing a new order for digoxin (Lanoxin). What is the priority nursing
assessment before administering the drug?

A. Blood pressure
B. Respiratory rate
C. Apical pulse ✅
D. Bowel sounds

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✅ Correct Answer: C. Apical pulse

🧠 Rationale:
Digoxin can cause bradycardia. The apical pulse should be checked for 1 full minute, and the
drug should be held if the heart rate is <60 bpm.



Question 4

Which adverse effect should the nurse monitor for in a patient receiving gentamicin?

A. Constipation
B. Tinnitus ✅
C. Rash
D. Hypertension

✅ Correct Answer: B. Tinnitus

🧠 Rationale:
Gentamicin is an aminoglycoside antibiotic that is ototoxic. Tinnitus, hearing loss, or balance
issues should be reported immediately.



Question 5

A patient taking lisinopril reports a persistent dry cough. What should the nurse anticipate?

A. The medication dose will be increased
B. The patient should increase fluid intake
C. The medication may be discontinued ✅
D. This is an expected side effect, and no action is needed

✅ Correct Answer: C. The medication may be discontinued

🧠 Rationale:
ACE inhibitors like lisinopril commonly cause a dry cough. It’s often persistent and
uncomfortable, leading providers to switch the patient to an ARB (like losartan).



Question 6

Which lab value should be monitored when a patient is on heparin therapy?