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WGU D027 OA Exam 2024/2025 | 100% Verified Test Bank with Correct Answers & Rationales (Latest 2025/2026 Update)

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Get exam-ready with this 100% Verified Test Bank for WGU D027 Advanced Pathopharmacological Foundations OA Exam – Updated for 2025/2026. This resource includes accurate questions, verified answers, and detailed rationales to help you understand the why behind each answer — not just memorize. Covers all major exam topics: Pathophysiological foundations of disease Pharmacokinetics & pharmacodynamics Medication safety & therapeutic uses Drug interactions & adverse effects Evidence-based pharmacology principles Includes: 100% verified questions Correct answers with rationales Organized for quick, effective review Ideal for WGU nursing & NP students preparing for the OA exam Latest 2025/2026 update Perfect for OA prep, revision, and mastery — this trusted WGU D027 Test Bank is your key to passing confidently on the first attempt.

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WGU D027 OA Exam 2024/2025 | 100% Verified Test Bank with
Correct Answers & Rationales (Latest Update)


What organ does cystic fibrosis affect? - correct answerAffects the pancreas causing
secretions into the lungs

What is Klinefelter syndrome? - correct answerAn extra X chromosome for males so
example XXY causing female-like qualities

What is Turner Syndrome? - correct answerfemales. missing or deformed x
chromosome. right hemisphere dysfunction, hearing loss, ear infection, language and
articulation disorders, visual spatial and attentional problems

What is beta thalassemia? - correct answera condition in which the synthesis of the
beta-globin chains is decreased or absent. Causes low hemoglobin.

Which medication is contraindicated in a patient with Beta Thalassemia? - correct
answerFerrous Sulfate

What drug is used in combination with other agent to treat lymphoid tissue (leukemia).
Directly toxic to lymphoid tissues Selective estrogen receptor modulators (SERM) - for
hormone receptor positive and advanced breast cancer. (Tomaxafin - reduces risk and
recurrence risk) - correct answerGlucocorticoids

What is the normal ejection fraction? - correct answer55-60%. Less than 50% is BAD

Is an ejection fraction of 50% reduced or preserved? - correct answerPreserved

What are symptoms of left sided heart failure? - correct answerThink PULMONARY.
JVD, FVO, rails, S3 murmurs. Number one cause of right sided heart failure!

What are symptoms of right sided heart failure? - correct answerThink peripheral
vascular. Lower extremity edema, abdominal distension.

What is the gold standard lab test for heart failure? - correct answerBNP. Heart failure is
a result greater than 100

What heart disease is worse with exertion? - correct answerIschemic heart disease
because the demand requirements are higher.

What should you assess before giving Digoxin? - correct answerApical pulse

How should Warfarin be started? - correct answerStart initial dose at half to monitor the
effects

,What causes the destruction of alveolar walls? Air goes in but can't get out which leads
to hyperinflation - correct answerEmphysema

What causes excess mucus production and smooth muscle hypertrophy? - correct
answerBronchitis

What is a chronic inflammatory obstruction of bronchi? - correct answerAsthma,
Triggers cause mucus to clog bronchial tubes.

What causes an overbite and buffalo hump? - correct answerEndocrine disorder called
acromegaly (overproduction of growth hormone)

What causes Addison's disease? - correct answerDecreased glucocorticoid (due to
autoimmune destruction of adrenal cortex)

What causes Cushing's syndrome? - correct answerexcess cortisol

What causes Grave's disease? - correct answeroverproduction of thyroid hormone.
HYPERthyroidism.

When should you instruct the patient to take their FIRST dose of antihypertensive? -
correct answerAt night to avoid orthostatic hypotension. Educate slow position changes
and lay down if needed.

What are side effects of ACE inhibitors? - correct answerdry cough
angioedema
hyperkalemia
*Contraindicated in pregnancy

Which type of antihypertensive should NOT be given to patients with Asthma? - correct
answerNonselective beta blocker (-lol) because both beta-2 receptors are effected

What is the first choice of calcium channel blocker? - correct answerVerapamil

What side effect should you watch for in a patient taking a statin drug? - correct
answerMuscle pain which can lead to rhabdomyolysis, kidney failure, and death.

Which diuretic is NOT used in patients with kidney failure and sickle cell disease? -
correct answerThiazide diuretics

What type of drug is spironolactone? - correct answerpotassium sparing diuretic

Which type of insulin is the most painful during injection? - correct answerLantus (long-
acting)

, Why test glycosylated hemoglobin (HgbA1c)? - correct answerMost reliable assessment
of blood sugar over the past 3 months. The goal is < 6.5%. A poor result is > 9%

What is the normal range for TSH level? - correct answerThe normal range of TSH
levels is 0.4 to 4.0 milli-international units per liter. If you're already being treated for a
thyroid disorder, the normal range is 0.5 to 3.0 milli-international units per liter. A value
ABOVE the normal range usually indicates hypothyroidism.

What lab test would we recommend for thyroid? - correct answerThyroid peroxidase
antibodies (TPO)

symptoms of hypothyroidism - correct answerBradycardia; cold intolerance; lethargy;
memory loss; dry skin; brittle dry hair; decreased appetite; weight gain; constipation;
increased serum lipids; decreased libido; erectile dysfunction

What if a newborn has hypothyroidism? - correct answerRequires replacement within a
few days and last for 3 years to prevent mental development changes and dwarfism.

What is Hashimoto's disease? - correct answerAn autoimmune cause of hypothyroid.
Symptoms include weight gain and fatigue.

Symptoms of hyperthyroidism (thyrotoxicosis) - correct answerTachyarrhythmias,
anxiety, insomnia, rapid flow/speech, hot
GRAVES DISEASE

how to treat grave's disease? - correct answerRemove or destroy thyroid tissue or
suppress with drug (methimazole or propylthiouracil)
Treat with Iodine-131
Beta blockers also used to suppress release of thyroid hormones and reduce HR.

What causes vasodilation, bronchoconstriction, and helps with memory and sleep? -
correct answerhistamine- 1

What are side effects of antihistamines? - correct answersedation (only H-1), dry mucus
membranes, urinary hesitancy, and constipation.

Which medication is given after an MI? - correct answerBeta blocker is given for 6
months to prevent another MI

When should medication reconciliation be done? - correct answerWithin 30 days of
discharge

Which drug class is used as the first line of treatment for depression? - correct
answerSSRIs because of the low side effects and effectiveness.

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