TEST BANK
NR566 Advanced Pharmacology – Care of
the Family | Final Exam
Study Guide with Verified Questions &
Correct Answers
Question: What are some potential drug interactions with Lithium?
Correct Answer: Diuretics, NSAIDs, Anticholinergics (concerned
with dehydration & sodium balance)
,Question: What is the black box warning for tricyclic antidepressants
and all other antidepressants as well?
Correct Answer: Risk for suicide
Question: What is the normal lithium therapeutic range?
Correct Answer: 0.4–1 mEq/L (levels >1.5 mEq/L approach toxicity)
Question: What is the role of androgens in treating anemia?
Correct Answer: Stimulate synthesis of erythropoietin
Question: Which drugs are known to elevate phenytoin levels?
Correct Answer: Diazepam, isoniazid, cimetidine, carbamazepine,
phenobarbital, alcohol
Question: What is the preferred administration route of alprostadil
(used to treat ED)?
Correct Answer: Injection into the penis or insertion into the
urethra
1. Which pharmacokinetic change during pregnancy most affects
drug dosing?
A. Decreased renal blood flow
B. Increased gastric pH
, C. Increased plasma protein binding
D. Decreased blood volume
Answer: B. Increased gastric pH
Rationale: Pregnancy increases gastric pH (less acidic), which can affect
absorption of weak acids; also increased renal clearance and volume—
but increased pH is a distinct change affecting drug bioavailability.
2. An APRN prescribes warfarin for a patient. Which laboratory test
is essential to monitor?
A. aPTT
B. INR
C. BUN/creatinine
D. Platelet count
Answer: B. INR
Rationale: Warfarin therapy is monitored via the International
Normalized Ratio (INR), to assess anticoagulation and bleeding risk.
3. A patient is started on a new drug metabolized by CYP3A4. She is
also taking grapefruit juice daily. What interaction risk exists?
A. Decreased drug effect
B. Increased drug plasma levels and toxicity
C. Enhanced renal excretion
D. No interaction
Answer: B. Increased drug plasma levels and toxicity
Rationale: Grapefruit juice inhibits CYP3A4, reducing metabolism and
, thereby increasing plasma levels of drugs that are CYP3A4 substrates—
raising risk of toxicity.
4. Which antibiotic is contraindicated in children due to risk of
cartilage damage?
A. Amoxicillin
B. Doxycycline
C. Azithromycin
D. Levofloxacin
Answer: D. Levofloxacin
Rationale: Fluoroquinolones (like levofloxacin) are typically avoided in
children because of risks to cartilage and joint development.
5. A patient on a statin reports new muscle pain and weakness.
Which lab should the APRN check first?
A. ALT/AST
B. CK (creatine kinase)
C. BUN
D. Total bilirubin
Answer: B. CK (creatine kinase)
Rationale: Elevated CK suggests statin-induced myopathy or
rhabdomyolysis; checking liver enzymes is also important but CK is
primary for muscle injury.
NR566 Advanced Pharmacology – Care of
the Family | Final Exam
Study Guide with Verified Questions &
Correct Answers
Question: What are some potential drug interactions with Lithium?
Correct Answer: Diuretics, NSAIDs, Anticholinergics (concerned
with dehydration & sodium balance)
,Question: What is the black box warning for tricyclic antidepressants
and all other antidepressants as well?
Correct Answer: Risk for suicide
Question: What is the normal lithium therapeutic range?
Correct Answer: 0.4–1 mEq/L (levels >1.5 mEq/L approach toxicity)
Question: What is the role of androgens in treating anemia?
Correct Answer: Stimulate synthesis of erythropoietin
Question: Which drugs are known to elevate phenytoin levels?
Correct Answer: Diazepam, isoniazid, cimetidine, carbamazepine,
phenobarbital, alcohol
Question: What is the preferred administration route of alprostadil
(used to treat ED)?
Correct Answer: Injection into the penis or insertion into the
urethra
1. Which pharmacokinetic change during pregnancy most affects
drug dosing?
A. Decreased renal blood flow
B. Increased gastric pH
, C. Increased plasma protein binding
D. Decreased blood volume
Answer: B. Increased gastric pH
Rationale: Pregnancy increases gastric pH (less acidic), which can affect
absorption of weak acids; also increased renal clearance and volume—
but increased pH is a distinct change affecting drug bioavailability.
2. An APRN prescribes warfarin for a patient. Which laboratory test
is essential to monitor?
A. aPTT
B. INR
C. BUN/creatinine
D. Platelet count
Answer: B. INR
Rationale: Warfarin therapy is monitored via the International
Normalized Ratio (INR), to assess anticoagulation and bleeding risk.
3. A patient is started on a new drug metabolized by CYP3A4. She is
also taking grapefruit juice daily. What interaction risk exists?
A. Decreased drug effect
B. Increased drug plasma levels and toxicity
C. Enhanced renal excretion
D. No interaction
Answer: B. Increased drug plasma levels and toxicity
Rationale: Grapefruit juice inhibits CYP3A4, reducing metabolism and
, thereby increasing plasma levels of drugs that are CYP3A4 substrates—
raising risk of toxicity.
4. Which antibiotic is contraindicated in children due to risk of
cartilage damage?
A. Amoxicillin
B. Doxycycline
C. Azithromycin
D. Levofloxacin
Answer: D. Levofloxacin
Rationale: Fluoroquinolones (like levofloxacin) are typically avoided in
children because of risks to cartilage and joint development.
5. A patient on a statin reports new muscle pain and weakness.
Which lab should the APRN check first?
A. ALT/AST
B. CK (creatine kinase)
C. BUN
D. Total bilirubin
Answer: B. CK (creatine kinase)
Rationale: Elevated CK suggests statin-induced myopathy or
rhabdomyolysis; checking liver enzymes is also important but CK is
primary for muscle injury.
