TEST BANK xz
Cellular and Molecular Immunology
xz xz xz
Abul Abbas, Andrew Lichtman, and Shiv Pillai
xz xz xz xz xz xz
10th Edition
xz
,Table of Contents
xz xz
Chapter 01 Properties and Overview of Immune Responses
xz xz xz xz xz xz xz 1
Chapter 02 Cells and Tissues of the Immune System
xz xz xz xz xz xz xz xz 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
xz xz xz xz xz xz xz 6
Chapter 04 Innate Immunity
xz xz xz 10
Chapter 05 Antibodies and Antigens
xz xz xz xz 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
xz xz xz xz xz xz xz xz xz xz xz
Histocompatibility Complex Molecules
xz xz 20
Chapter 07 Immune Receptors and Signal Transduction
xz xz xz xz xz xz 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
xz xz xz xz xz xz xz xz 30
Chapter 09 Activation of T Lymphocytes
xz xz xz xz xz 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
xz xz xz xz xz xz xz xz xz 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
xz xz xz xz xz xz xz xz xz 42
Chapter 12 B Cell Activation and Antibody Production
xz xz xz xz xz xz xz 46
Chapter 13 Effector Mechanisms of Humoral Immunity
xz xz xz xz xz xz 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
xz xz xz xz xz xz xz xz xz xz xz 56
Chapter 15 Immunologic Tolerance and Autoimmunity
xz xz xz xz xz 62
Chapter 16 Immunity to Microbes
xz xz xz xz 67
Chapter 17 Transplantation Immunology
xz xz xz 72
Chapter 18 Tumor Immunology
xz xz xz 77
Chapter 19 Hypersensitivity Disorders
xz xz xz 81
Chapter 20 Allergy
xz xz 86
Chapter 21 Primary and Acquired Immunodeficiencies
xz xz xz xz xz 89
,Chapter 01: Properties and Overview of Immune Responses
xz xz xz xz xz xz xz
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
xz xz xz xz xz xz xz xz xz
MULTIPLE CHOICE xz
1. The principal function of the immune system is:
xz xz xz xz xz xz xz
a. Defense against cancer xz xz
b. Repair of injured tissues xz xz xz
c. Defense against microbial infections xz xz xz
d. Prevention of inflammatory diseases xz xz xz
e. Protection against environmental toxins xz xz xz
ANS: C x z
The immune system has evolved in the setting of selective pressures imposed by microbia
xz xz xz xz xz xz xz xz xz xz xz xz xz
l infections. Although immune responses to cancer may occur, the concept that ―immuno
xz xz xz xz xz xz xz xz xz xz xz xz
surveillance‖ against cancer is a principal function of the immune system is controversial
xz xz xz xz xz xz xz xz xz xz xz xz
. Repair of injured tissues may be a secondary consequence of the immune responses and
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
inflammation. Although the immune system has regulatory features that are needed to pr
xz xz xz xz xz xz xz xz xz xz xz xz xz
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
xz xz xz xz xz xz xz xz xz xz xz
ion. The immune system can protect against microbial toxins, but it generally does not off
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
er protection against toxins of nonbiologic origin.
xz xz xz xz xz xz
2. Which of the following infectious diseases was prevented by the first successfu
xz xz xz xz xz xz xz xz xz xz xz
l vaccination?
xz
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C x z
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
xz xz xz xz xz xz xz xz xz xz xz xz
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
xz xz xz xz xz xz xz xz xz xz xz xz xz
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
xz xz xz xz xz xz xz xz xz xz xz xz xz
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
xz xz xz xz xz xz xz xz xz xz xz xz
osis.
3. Which of the following is a unique property of the adaptive immune system?
xz xz xz xz xz xz xz xz xz xz xz xz
a. Highly diverse repertoire of specificities for antigens
xz xz xz xz xz xz
b. Self-nonself discrimination xz
c. Recognition of microbial structures by both cell-associated and soluble receptors
xz xz xz xz xz xz xz xz xz
d. Protection against viral infections xz xz xz
e. Responses that have the same kinetics and magnitude on repeated exposure to th
xz xz xz xz xz xz xz xz xz xz xz xz
e same microbe xz xz
ANS: x z A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
cytes, which are the central cellular components of the adaptive immune system. Both th
xz xz xz xz xz xz xz xz xz xz xz xz xz
e innate and the adaptive immune systems use cell-
xz xz xz xz xz xz xz xz
associated and soluble receptors to recognize microbes, display some degree of self-
xz xz xz xz xz xz xz xz xz xz xz
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
xz xz xz xz xz xz xz xz xz xz xz xz
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
xz xz xz xz xz xz xz xz xz xz xz xz xz
s the manifestation of memory.
xz xz xz xz
4. Antibodies and T lymphocytes are the respective mediators of which two types o
xz xz xz xz xz xz xz xz xz xz xz xz
f immunity?
xz
a. Innate and adaptive xz xz
b. Passive and active xz xz
c. Specific and nonspecific xz xz
d. Humoral and cell-mediated xz xz
e. Adult and neonatal xz xz
ANS: D x z
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
xz xz xz xz xz xz xz xz xz xz xz xz
s produce antibodies, which are the recognition and effector molecules of humoral immun
xz xz xz xz xz xz xz xz xz xz xz xz
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
xz xz xz xz xz xz xz xz xz xz xz xz
ellular pathogens in cell-
xz xz xz
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
xz xz xz xz xz xz xz xz xz xz xz xz xz
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
xz xz xz xz xz xz xz xz xz xz xz xz xz
d.
5. The two major functional classes of effector T lymphocytes are:
xz xz xz xz xz xz xz xz xz
a. Helper T lymphocytes and cytotoxic T lymphocytes
xz xz xz xz xz xz
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
xz xz xz xz
c. Memory T cells and effector T cells xz xz xz xz xz xz
d. Helper cells and antigen-presenting cells xz xz xz xz
e. Cytotoxic T lymphocytes and target cells xz xz xz xz xz
ANS: A x z
T cells can be classified into effector subsets that perform different effector functions. Mos
xz xz xz xz xz xz xz xz xz xz xz xz xz
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
xz xz xz xz xz xz xz xz xz xz xz xz
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
xz xz xz xz xz xz xz xz xz xz xz xz
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. xz xz xz xz xz xz xz xz xz xz xz xz xz xz
6. Which of the following cell types is required for all adaptive humoral immune responses?
xz xz xz xz xz xz xz xz xz xz xz xz xz
a. Natural killer cells xz xz
b. Dendritic cells xz
c. Cytolytic T lymphocytes xz xz
d. B lymphocytes xz
e. Helper T lymphocytes xz xz
ANS: D x z
Humoral immune responses are antibody- xz xz xz xz
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
xz xz xz xz xz xz xz xz xz xz xz xz xz
er cell type.
xz xz
Cellular and Molecular Immunology
xz xz xz
Abul Abbas, Andrew Lichtman, and Shiv Pillai
xz xz xz xz xz xz
10th Edition
xz
,Table of Contents
xz xz
Chapter 01 Properties and Overview of Immune Responses
xz xz xz xz xz xz xz 1
Chapter 02 Cells and Tissues of the Immune System
xz xz xz xz xz xz xz xz 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
xz xz xz xz xz xz xz 6
Chapter 04 Innate Immunity
xz xz xz 10
Chapter 05 Antibodies and Antigens
xz xz xz xz 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
xz xz xz xz xz xz xz xz xz xz xz
Histocompatibility Complex Molecules
xz xz 20
Chapter 07 Immune Receptors and Signal Transduction
xz xz xz xz xz xz 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
xz xz xz xz xz xz xz xz 30
Chapter 09 Activation of T Lymphocytes
xz xz xz xz xz 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
xz xz xz xz xz xz xz xz xz 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
xz xz xz xz xz xz xz xz xz 42
Chapter 12 B Cell Activation and Antibody Production
xz xz xz xz xz xz xz 46
Chapter 13 Effector Mechanisms of Humoral Immunity
xz xz xz xz xz xz 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
xz xz xz xz xz xz xz xz xz xz xz 56
Chapter 15 Immunologic Tolerance and Autoimmunity
xz xz xz xz xz 62
Chapter 16 Immunity to Microbes
xz xz xz xz 67
Chapter 17 Transplantation Immunology
xz xz xz 72
Chapter 18 Tumor Immunology
xz xz xz 77
Chapter 19 Hypersensitivity Disorders
xz xz xz 81
Chapter 20 Allergy
xz xz 86
Chapter 21 Primary and Acquired Immunodeficiencies
xz xz xz xz xz 89
,Chapter 01: Properties and Overview of Immune Responses
xz xz xz xz xz xz xz
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
xz xz xz xz xz xz xz xz xz
MULTIPLE CHOICE xz
1. The principal function of the immune system is:
xz xz xz xz xz xz xz
a. Defense against cancer xz xz
b. Repair of injured tissues xz xz xz
c. Defense against microbial infections xz xz xz
d. Prevention of inflammatory diseases xz xz xz
e. Protection against environmental toxins xz xz xz
ANS: C x z
The immune system has evolved in the setting of selective pressures imposed by microbia
xz xz xz xz xz xz xz xz xz xz xz xz xz
l infections. Although immune responses to cancer may occur, the concept that ―immuno
xz xz xz xz xz xz xz xz xz xz xz xz
surveillance‖ against cancer is a principal function of the immune system is controversial
xz xz xz xz xz xz xz xz xz xz xz xz
. Repair of injured tissues may be a secondary consequence of the immune responses and
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
inflammation. Although the immune system has regulatory features that are needed to pr
xz xz xz xz xz xz xz xz xz xz xz xz xz
event excessive inflammation, prevention of inflammatory diseases is not a primary funct
xz xz xz xz xz xz xz xz xz xz xz
ion. The immune system can protect against microbial toxins, but it generally does not off
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
er protection against toxins of nonbiologic origin.
xz xz xz xz xz xz
2. Which of the following infectious diseases was prevented by the first successfu
xz xz xz xz xz xz xz xz xz xz xz
l vaccination?
xz
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C x z
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
xz xz xz xz xz xz xz xz xz xz xz xz
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980,
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
smallpox was reported to be eradicated worldwide by a vaccination program. Effective v
xz xz xz xz xz xz xz xz xz xz xz xz xz
accines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th ce
xz xz xz xz xz xz xz xz xz xz xz xz xz
ntury and are widely used. There is no effective vaccine against Mycobacterium tubercul
xz xz xz xz xz xz xz xz xz xz xz xz
osis.
3. Which of the following is a unique property of the adaptive immune system?
xz xz xz xz xz xz xz xz xz xz xz xz
a. Highly diverse repertoire of specificities for antigens
xz xz xz xz xz xz
b. Self-nonself discrimination xz
c. Recognition of microbial structures by both cell-associated and soluble receptors
xz xz xz xz xz xz xz xz xz
d. Protection against viral infections xz xz xz
e. Responses that have the same kinetics and magnitude on repeated exposure to th
xz xz xz xz xz xz xz xz xz xz xz xz
e same microbe xz xz
ANS: x z A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
xz xz xz xz xz xz xz xz xz xz xz xz xz xz
cytes, which are the central cellular components of the adaptive immune system. Both th
xz xz xz xz xz xz xz xz xz xz xz xz xz
e innate and the adaptive immune systems use cell-
xz xz xz xz xz xz xz xz
associated and soluble receptors to recognize microbes, display some degree of self-
xz xz xz xz xz xz xz xz xz xz xz
nonself discrimination, and protect against viruses. On repeated exposure to the same mic
xz xz xz xz xz xz xz xz xz xz xz xz
robe, the adaptive immune response becomes more rapid and of greater magnitude; this i
xz xz xz xz xz xz xz xz xz xz xz xz xz
s the manifestation of memory.
xz xz xz xz
4. Antibodies and T lymphocytes are the respective mediators of which two types o
xz xz xz xz xz xz xz xz xz xz xz xz
f immunity?
xz
a. Innate and adaptive xz xz
b. Passive and active xz xz
c. Specific and nonspecific xz xz
d. Humoral and cell-mediated xz xz
e. Adult and neonatal xz xz
ANS: D x z
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
xz xz xz xz xz xz xz xz xz xz xz xz
s produce antibodies, which are the recognition and effector molecules of humoral immun
xz xz xz xz xz xz xz xz xz xz xz xz
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
xz xz xz xz xz xz xz xz xz xz xz xz
ellular pathogens in cell-
xz xz xz
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymph
xz xz xz xz xz xz xz xz xz xz xz xz xz
ocytes participate in adult adaptive immunity but are still developing in the neonatal perio
xz xz xz xz xz xz xz xz xz xz xz xz xz
d.
5. The two major functional classes of effector T lymphocytes are:
xz xz xz xz xz xz xz xz xz
a. Helper T lymphocytes and cytotoxic T lymphocytes
xz xz xz xz xz xz
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes
xz xz xz xz
c. Memory T cells and effector T cells xz xz xz xz xz xz
d. Helper cells and antigen-presenting cells xz xz xz xz
e. Cytotoxic T lymphocytes and target cells xz xz xz xz xz
ANS: A x z
T cells can be classified into effector subsets that perform different effector functions. Mos
xz xz xz xz xz xz xz xz xz xz xz xz xz
t effector T cells are either helper T lymphocytes, which enhance the responses of other i
xz xz xz xz xz xz xz xz xz xz xz xz xz xz xz
mmune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocytes
xz xz xz xz xz xz xz xz xz xz xz xz
, which directly kill infected cells. Natural killer cells are not T lymphocytes.
xz xz xz xz xz xz xz xz xz xz xz xz
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. xz xz xz xz xz xz xz xz xz xz xz xz xz xz
6. Which of the following cell types is required for all adaptive humoral immune responses?
xz xz xz xz xz xz xz xz xz xz xz xz xz
a. Natural killer cells xz xz
b. Dendritic cells xz
c. Cytolytic T lymphocytes xz xz
d. B lymphocytes xz
e. Helper T lymphocytes xz xz
ANS: D x z
Humoral immune responses are antibody- xz xz xz xz
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
xz xz xz xz xz xz xz xz xz xz xz xz xz
er cell type.
xz xz
