Nurse Practitioner (AGACNP-BC)
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What does bleeding look like in the different parts of digestive system - ANSWER
✓ hematesis- stomach, coffee grounds lower GI melena -lower GI
S/S of PUD - ANSWER ✓ Gnawing epigastric pain
relief with eating (duodenal)
Pain worse with eating (gastric)
Physical findings of PUD - ANSWER ✓ often unremarkable; may note some mild
epigastric tenderness
GI bleeding: melena, hematemesis or coffee ground emesis
Perforation: Severe epigastric pain, "board-like" abdomen, quiet BS, rigidity and
other s/s of acute abdomen
Tinkeling BS= Obstruction
Lab/Diagnostics of PUD - ANSWER ✓ Normal; anemia on CBC
Consider endoscopy after 2-8 weeks of treatment
Consider H pylori testing
PPI (proton pump inhibitor) - ANSWER ✓ Causes rebound GERD when coming
off.
Prevacid, aciphex, protonix, prilosec, dexilant, nexium
H2 receptors - ANSWER ✓ tagament, antac, pepcid, axid
, Mucosal Protective agents - ANSWER ✓ give 2 hours apart form other
medications
sucralfate 1gm/qid: Requires acidic environment (avoid antacids and H2 blockers)
Associated with decreases in nosocomial pneumonia
Pepto-Bismal
Cytotec
Antacids
H. Pylori Eradication therapy - ANSWER ✓ Resistance: Develops quickly to
Flagyl and Biaxin
Does not develop quickly to amoxicillin or tetracycline
Combo options: 2 antibiotics+ PPI or bismuth
Quadrants and Abdomen pain - ANSWER ✓ LLQ diverticulitis
RUQ galbladder
Peri-umbilical- appendicitis
Causes of Obstruction - ANSWER ✓ Adhesions
Cancer
Impaction
GERD - ANSWER ✓ A disorder characterized by back flow of acidic gastric
intents into the espohagus
Causes/Incidence of GERD - ANSWER ✓ Incompetent lower esophageal
sphincter
delayed gastric emptying
S/S of GERD - ANSWER ✓ retrosternal burning, bitter taste, belching,dysphagia,
excessive salivation, occurs at night or in recumbent position, relieved by sitting up
Diagnostics of GERD - ANSWER ✓ consider referral for EGD: rule out CA,
Barrett's esophagus
Management of GERD - ANSWER ✓ Elevate HOB
Avoid ETOH, caffeine, spices, peppermint
stop smoking and weight reduction
antacids PRN
,H2 blockers (-tidines)
PPI (-zoles)
GI/Surgical consult PRN
Acid anti-secretory agents for PUD - ANSWER ✓ H2 receptor antagonists
"dines": Cimetidine (tagamet) Ranitidine (zantac) Famotidine (pepcid) Nizatidine
(Axid)
Proton Pump inhibitors "zoles": Lanzoprazole, (prevacid) Omeprazole(prilosec)
pantoprazole (prilosec) ans Esomeprazole (nexium) Used for patients that cannot
discontinue NSAIDS as well
Mucosal protecting Agents PUD - ANSWER ✓ "coats"ulcer
sucralfate, Bismuth, Misoprostol (may stimulate uterine contraction-abortion)
Antacids: Milanta and Maalox, do not decrease gastric acidity
H-Pylori therapy - ANSWER ✓ combination therapy used for 7 days
2 antibiotics + proton pump inhibitor or bismuth (not as popular due to QID
dosing)
use combo because resistance develops quickly to metronidazole (flagyl) and
Clarithromycin (Biaxin)
But not to amoxicillin and or tetracycline
so ABX 2X a day with meals and Omeprazole (prilosec)before meals
Antiulcer therapy follows this prilosec and H2 blockers for 3-7 weeks
Hepatitis - ANSWER ✓ Inflammation of the liver, with resultant liver dysfunction
types: A, B, C, E, G
Hep A - ANSWER ✓ an enteral virus, transmitted via the oral fecal-route and
rarely, parenterally
Contaminated water and food; oral sex!
blood and stool are infectious during 2-6 week incubation period
Hep B - ANSWER ✓ Blood borne DNA virus present in serum, saliva, semen,
and vaginal secretions.
Transmitted via blood and blood products, sexual activity and mother fetus
Hep C - ANSWER ✓ Blood bore RNA virus in which the source of infection is
often uncertain
Traditionally associated with blood transfusions
, 50% cases are related to IV drug use
Leading cause of liver transplant
S/S of Hepatitis - ANSWER ✓ Pre-icteric: Fever, malaise, anorexia, N/V,
headache, aversion to smoking and alcohol
Icteric: Weight loss, jaundice,pruritus, right upper quad pain, clay colored stool,
dark urine
Lab/diagnostics of Hepatitis - ANSWER ✓ WBC: low to normal
UA: proteinuria, bilirubinuria
Elevated AST and ALT (500-2000) norma 35-40
LDH, bilirubin, alkaline phosphatase, and PT normal or slightly elevated
Management of Hepatitis - ANSWER ✓ Increase fluids to 3,000 to 4,000/day
no/low protein diet: cause ammonia
Serax if sedation is necessary
Vit K for prolonged PT (>15 sec)
Lactulose 30ml orally or rectally for elevated ammonia levels: hepatic
encephalophathy
Diverticulitis - ANSWER ✓ Inflammation or localized perforation of one or more
diverticula with abscess formation
Causes/Incidence of Diverticulitis - ANSWER ✓ More common in women than
men
Higher incidence in those with low dietary fiber
S/S of Diverticulitis - ANSWER ✓ mild to moderate aching abdominal pain in
LLQ
Constipation or loose stools
Nausea and vomiting
Physical findings of diverticulitis - ANSWER ✓ Low grade fever
LLQ tenderness ot palpation
Lab/Diagnostic of Diverticulitis - ANSWER ✓ Mild to mod leukocytosis, elevated
ESR, Stool heme + in 25 % of cases, plain and films are obtained on all patients to
look for evidence of free air