TEST BANK 5%
Cellular and Molecular Immunology
5% 5% 5%
Abul Abbas, Andrew Lichtman, and Shiv Pillai
5% 5% 5% 5% 5% 5%
10th Edition
5%
,Table of Contents
5% 5%
Chapter 01 Properties and Overview of Immune Responses
5% 5% 5% 5% 5% 5% 5% 1
Chapter 02 Cells and Tissues of the Immune System
5% 5% 5% 5% 5% 5% 5% 5% 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
5% 5% 5% 5% 5% 5% 5% 6
Chapter 04 Innate Immunity
5% 5% 5% 10
Chapter 05 Antibodies and Antigens
5% 5% 5% 5% 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
Histocompatibility Complex Molecules
5% 5% 20
Chapter 07 Immune Receptors and Signal Transduction
5% 5% 5% 5% 5% 5% 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
5% 5% 5% 5% 5% 5% 5% 5% 30
Chapter 09 Activation of T Lymphocytes
5% 5% 5% 5% 5% 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
5% 5% 5% 5% 5% 5% 5% 5% 5% 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
5% 5% 5% 5% 5% 5% 5% 5% 5% 42
Chapter 12 B Cell Activation and Antibody Production
5% 5% 5% 5% 5% 5% 5% 46
Chapter 13 Effector Mechanisms of Humoral Immunity
5% 5% 5% 5% 5% 5% 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 56
Chapter 15 Immunologic Tolerance and Autoimmunity
5% 5% 5% 5% 5% 62
Chapter 16 Immunity to Microbes
5% 5% 5% 5% 67
Chapter 17 Transplantation Immunology
5% 5% 5% 72
Chapter 18 Tumor Immunology
5% 5% 5% 77
Chapter 19 Hypersensitivity Disorders
5% 5% 5% 81
Chapter 20 Allergy
5% 5% 86
Chapter 21 Primary and Acquired Immunodeficiencies
5% 5% 5% 5% 5% 89
,Chapter 01: Properties and Overview of Immune Responses
5% 5% 5% 5% 5% 5% 5%
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
5% 5% 5% 5% 5% 5% 5% 5% 5%
MULTIPLE CHOICE 5%
1. The principal function of the immune system is:
5% 5% 5% 5% 5% 5% 5%
a. Defense against cancer 5% 5%
b. Repair of injured tissues 5% 5% 5%
c. Defense against microbial infections 5% 5% 5%
d. Prevention of inflammatory diseases 5% 5% 5%
e. Protection against environmental toxins 5% 5% 5%
ANS: C 5 %
The immune system has evolved in the setting of selective pressures imposed by microbi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
al infections. Although immune responses to cancer may occur, the concept that “immun
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
osurveillance” against cancer is a principal function of the immune system is controversi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
al. Repair of injured tissues may be a secondary consequence of the immune responses a
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nd inflammation. Although the immune system has regulatory features that are needed to
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
prevent excessive inflammation, prevention of inflammatory diseases is not a primary fu
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nction. The immune system can protect against microbial toxins, but it generally does not
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5
offer protection against toxins of nonbiologic origin.
% 5% 5% 5% 5% 5% 5%
2. Which of the following infectious diseases was prevented by the first successf
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ul vaccination?
5%
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C 5 %
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
entury and are widely used. There is no effective vaccine against Mycobacterium tuberc
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ulosis.
3. Which of the following is a unique property of the adaptive immune system?
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Highly diverse repertoire of specificities for antigens
5% 5% 5% 5% 5% 5%
b. Self-nonself discrimination 5%
c. Recognition of microbial structures by both cell-associated and soluble receptors
5% 5% 5% 5% 5% 5% 5% 5% 5%
d. Protection against viral infections 5% 5% 5%
e. Responses that have the same kinetics and magnitude on repeated exposure to t
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
he same microbe 5% 5%
ANS: 5 % A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
cytes, which are the central cellular components of the adaptive immune system. Both th
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
e innate and the adaptive immune systems use cell-
5% 5% 5% 5% 5% 5% 5% 5%
associated and soluble receptors to recognize microbes, display some degree of self-
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nonself discrimination, and protect against viruses. On repeated exposure to the same mi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5
is the manifestation of memory.
% 5% 5% 5% 5%
4. Antibodies and T lymphocytes are the respective mediators of which two types
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
of immunity?
5%
a. Innate and adaptive 5% 5%
b. Passive and active 5% 5%
c. Specific and nonspecific 5% 5%
d. Humoral and cell-mediated 5% 5%
e. Adult and neonatal 5% 5%
ANS: D 5 %
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
s produce antibodies, which are the recognition and effector molecules of humoral immun
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ellular pathogens in cell- 5% 5% 5%
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
hocytes participate in adult adaptive immunity but are still developing in the neonatal peri
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
od.
5. The two major functional classes of effector T lymphocytes are:
5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Helper T lymphocytes and cytotoxic T lymphocytes 5% 5% 5% 5% 5% 5%
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes 5% 5% 5% 5%
c. Memory T cells and effector T cells 5% 5% 5% 5% 5% 5%
d. Helper cells and antigen-presenting cells 5% 5% 5% 5%
e. Cytotoxic T lymphocytes and target cells 5% 5% 5% 5% 5%
ANS: A 5 %
T cells can be classified into effector subsets that perform different effector functions. Mo
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
st effector T cells are either helper T lymphocytes, which enhance the responses of other
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
es, which directly kill infected cells. Natural killer cells are not T lymphocytes.
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
6. Which of the following cell types is required for all adaptive humoral immune responses?
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Natural killer cells 5% 5%
b. Dendritic cells 5%
c. Cytolytic T lymphocytes 5% 5%
d. B lymphocytes 5%
e. Helper T lymphocytes 5% 5%
ANS: D 5 %
Humoral immune responses are antibody- 5% 5% 5% 5%
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
er cell type.
5% 5%
Cellular and Molecular Immunology
5% 5% 5%
Abul Abbas, Andrew Lichtman, and Shiv Pillai
5% 5% 5% 5% 5% 5%
10th Edition
5%
,Table of Contents
5% 5%
Chapter 01 Properties and Overview of Immune Responses
5% 5% 5% 5% 5% 5% 5% 1
Chapter 02 Cells and Tissues of the Immune System
5% 5% 5% 5% 5% 5% 5% 5% 3
Chapter 03 Leukocyte Circulation and Migration Into Tissues
5% 5% 5% 5% 5% 5% 5% 6
Chapter 04 Innate Immunity
5% 5% 5% 10
Chapter 05 Antibodies and Antigens
5% 5% 5% 5% 17
Chapter 06 Antigen Presentation to T Lymphocytes and the Functions of Major
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
Histocompatibility Complex Molecules
5% 5% 20
Chapter 07 Immune Receptors and Signal Transduction
5% 5% 5% 5% 5% 5% 27
Chapter 08 Lymphocyte Development and Antigen Receptor Gene Rearrangement
5% 5% 5% 5% 5% 5% 5% 5% 30
Chapter 09 Activation of T Lymphocytes
5% 5% 5% 5% 5% 34
Chapter 10 Differentiation and Functions of CD4+ Effector T Cells
5% 5% 5% 5% 5% 5% 5% 5% 5% 38
Chapter 11 Differentiation and Functions of CD8+ Effector T Cells
5% 5% 5% 5% 5% 5% 5% 5% 5% 42
Chapter 12 B Cell Activation and Antibody Production
5% 5% 5% 5% 5% 5% 5% 46
Chapter 13 Effector Mechanisms of Humoral Immunity
5% 5% 5% 5% 5% 5% 52
Chapter 14 Specialized Immunity at Epithelial Barriers and in Immune Privileged Tissues
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 56
Chapter 15 Immunologic Tolerance and Autoimmunity
5% 5% 5% 5% 5% 62
Chapter 16 Immunity to Microbes
5% 5% 5% 5% 67
Chapter 17 Transplantation Immunology
5% 5% 5% 72
Chapter 18 Tumor Immunology
5% 5% 5% 77
Chapter 19 Hypersensitivity Disorders
5% 5% 5% 81
Chapter 20 Allergy
5% 5% 86
Chapter 21 Primary and Acquired Immunodeficiencies
5% 5% 5% 5% 5% 89
,Chapter 01: Properties and Overview of Immune Responses
5% 5% 5% 5% 5% 5% 5%
Abbas, Lichtman, and Pillai: Cellular and Molecular Immunology, 10th Edition
5% 5% 5% 5% 5% 5% 5% 5% 5%
MULTIPLE CHOICE 5%
1. The principal function of the immune system is:
5% 5% 5% 5% 5% 5% 5%
a. Defense against cancer 5% 5%
b. Repair of injured tissues 5% 5% 5%
c. Defense against microbial infections 5% 5% 5%
d. Prevention of inflammatory diseases 5% 5% 5%
e. Protection against environmental toxins 5% 5% 5%
ANS: C 5 %
The immune system has evolved in the setting of selective pressures imposed by microbi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
al infections. Although immune responses to cancer may occur, the concept that “immun
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
osurveillance” against cancer is a principal function of the immune system is controversi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
al. Repair of injured tissues may be a secondary consequence of the immune responses a
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nd inflammation. Although the immune system has regulatory features that are needed to
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
prevent excessive inflammation, prevention of inflammatory diseases is not a primary fu
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nction. The immune system can protect against microbial toxins, but it generally does not
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5
offer protection against toxins of nonbiologic origin.
% 5% 5% 5% 5% 5% 5%
2. Which of the following infectious diseases was prevented by the first successf
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ul vaccination?
5%
a. Polio
b. Tuberculosis
c. Smallpox
d. Tetanus
e. Rubella
ANS: C 5 %
In 1798, Edward Jenner reported the first intentional successful vaccination, which was a
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
gainst smallpox in a boy, using material from the cowpox pustules of a milkmaid. In 1980
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
, smallpox was reported to be eradicated worldwide by a vaccination program. Effective
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
vaccines against tetanus toxin, rubella virus, and poliovirus were developed in the 20th c
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
entury and are widely used. There is no effective vaccine against Mycobacterium tuberc
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ulosis.
3. Which of the following is a unique property of the adaptive immune system?
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Highly diverse repertoire of specificities for antigens
5% 5% 5% 5% 5% 5%
b. Self-nonself discrimination 5%
c. Recognition of microbial structures by both cell-associated and soluble receptors
5% 5% 5% 5% 5% 5% 5% 5% 5%
d. Protection against viral infections 5% 5% 5%
e. Responses that have the same kinetics and magnitude on repeated exposure to t
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
he same microbe 5% 5%
ANS: 5 % A
, Highly diverse repertoires of specificities for antigens are found only in T and B lympho
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
cytes, which are the central cellular components of the adaptive immune system. Both th
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
e innate and the adaptive immune systems use cell-
5% 5% 5% 5% 5% 5% 5% 5%
associated and soluble receptors to recognize microbes, display some degree of self-
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
nonself discrimination, and protect against viruses. On repeated exposure to the same mi
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
crobe, the adaptive immune response becomes more rapid and of greater magnitude; this
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5
is the manifestation of memory.
% 5% 5% 5% 5%
4. Antibodies and T lymphocytes are the respective mediators of which two types
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
of immunity?
5%
a. Innate and adaptive 5% 5%
b. Passive and active 5% 5%
c. Specific and nonspecific 5% 5%
d. Humoral and cell-mediated 5% 5%
e. Adult and neonatal 5% 5%
ANS: D 5 %
Both B and T lymphocytes are principal components of adaptive immunity. B lymphocyte
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
s produce antibodies, which are the recognition and effector molecules of humoral immun
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
e responses to extracellular pathogens. T cells recognize and promote eradication of intrac
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
ellular pathogens in cell- 5% 5% 5%
mediated immunity. Passive and active immunity both can be mediated by either B or T ly
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
mphocytes. Specific immunity is another term for adaptive immunity. Both B and T lymp
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
hocytes participate in adult adaptive immunity but are still developing in the neonatal peri
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
od.
5. The two major functional classes of effector T lymphocytes are:
5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Helper T lymphocytes and cytotoxic T lymphocytes 5% 5% 5% 5% 5% 5%
b. Natural killer cells and cytoWtoWxW
ic.TTlB
yS
mMph.oW
cyStes 5% 5% 5% 5%
c. Memory T cells and effector T cells 5% 5% 5% 5% 5% 5%
d. Helper cells and antigen-presenting cells 5% 5% 5% 5%
e. Cytotoxic T lymphocytes and target cells 5% 5% 5% 5% 5%
ANS: A 5 %
T cells can be classified into effector subsets that perform different effector functions. Mo
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
st effector T cells are either helper T lymphocytes, which enhance the responses of other
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
immune cells, including phagocytes and B cells, to infections, or cytotoxic T lymphocyt
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
es, which directly kill infected cells. Natural killer cells are not T lymphocytes.
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
Antigen-presenting cells usually are not T cells. Memory T cells are not effector T cells. 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
6. Which of the following cell types is required for all adaptive humoral immune responses?
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
a. Natural killer cells 5% 5%
b. Dendritic cells 5%
c. Cytolytic T lymphocytes 5% 5%
d. B lymphocytes 5%
e. Helper T lymphocytes 5% 5%
ANS: D 5 %
Humoral immune responses are antibody- 5% 5% 5% 5%
mediated immune responses, and all antibodies are made by B lymphocytes and no oth
5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5% 5%
er cell type.
5% 5%
