Walden University - NURS 6501 Advanced
Pathophysiology — Practice Final Exam
Format: 80 multiple-choice questions. Choose the single best answer. Original practice content only;
not an actual Walden exam.
,1. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
2. What is the primary defect in sickle cell disease?
A. Abnormal hemoglobin polymerization
B. Iron deficiency
C. Lack of folate
D. Platelet dysfunction
3. Which compensation occurs in metabolic acidosis?
A. Hyperventilation
B. Hypoventilation
C. Increased H+ secretion
D. Increased bicarbonate retention
4. Which mechanism underlies Type 1 diabetes mellitus?
A. Insulin resistance
B. Autoimmune beta-cell destruction
C. Excess cortisol secretion
D. Increased glucagon
5. Graves’ disease is characterized by which lab profile?
A. Low TSH, high T4
B. High TSH, low T4
C. High cortisol, low ACTH
D. Low insulin, high glucose
6. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
C. X-linked mutation
D. Chromosomal trisomy
7. What is the primary defect in sickle cell disease?
A. Abnormal hemoglobin polymerization
B. Iron deficiency
C. Lack of folate
D. Platelet dysfunction
8. Increased intracranial pressure is most directly caused by:
A. Increased CSF, brain edema, or hemorrhage
B. Reduced blood volume
C. Decreased PaCO■
D. Reduced CSF production
9. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
, C. X-linked mutation
D. Chromosomal trisomy
10. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
11. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
12. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
13. Increased intracranial pressure is most directly caused by:
A. Increased CSF, brain edema, or hemorrhage
B. Reduced blood volume
C. Decreased PaCO■
D. Reduced CSF production
14. Graves’ disease is characterized by which lab profile?
A. Low TSH, high T4
B. High TSH, low T4
C. High cortisol, low ACTH
D. Low insulin, high glucose
15. Which mediator primarily increases vascular permeability in acute inflammation?
A. Histamine
B. Aldosterone
C. Cortisol
D. Insulin
16. A patient with left-sided heart failure is most likely to develop:
A. Pulmonary edema
B. Peripheral edema only
C. JVD
D. Hepatomegaly
17. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
C. X-linked mutation
D. Chromosomal trisomy
18. Which mechanism underlies Type 1 diabetes mellitus?
Pathophysiology — Practice Final Exam
Format: 80 multiple-choice questions. Choose the single best answer. Original practice content only;
not an actual Walden exam.
,1. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
2. What is the primary defect in sickle cell disease?
A. Abnormal hemoglobin polymerization
B. Iron deficiency
C. Lack of folate
D. Platelet dysfunction
3. Which compensation occurs in metabolic acidosis?
A. Hyperventilation
B. Hypoventilation
C. Increased H+ secretion
D. Increased bicarbonate retention
4. Which mechanism underlies Type 1 diabetes mellitus?
A. Insulin resistance
B. Autoimmune beta-cell destruction
C. Excess cortisol secretion
D. Increased glucagon
5. Graves’ disease is characterized by which lab profile?
A. Low TSH, high T4
B. High TSH, low T4
C. High cortisol, low ACTH
D. Low insulin, high glucose
6. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
C. X-linked mutation
D. Chromosomal trisomy
7. What is the primary defect in sickle cell disease?
A. Abnormal hemoglobin polymerization
B. Iron deficiency
C. Lack of folate
D. Platelet dysfunction
8. Increased intracranial pressure is most directly caused by:
A. Increased CSF, brain edema, or hemorrhage
B. Reduced blood volume
C. Decreased PaCO■
D. Reduced CSF production
9. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
, C. X-linked mutation
D. Chromosomal trisomy
10. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
11. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
12. Which finding is typical of nephrotic syndrome?
A. Proteinuria >3.5 g/day
B. Hematuria only
C. Low serum lipids
D. Increased GFR
13. Increased intracranial pressure is most directly caused by:
A. Increased CSF, brain edema, or hemorrhage
B. Reduced blood volume
C. Decreased PaCO■
D. Reduced CSF production
14. Graves’ disease is characterized by which lab profile?
A. Low TSH, high T4
B. High TSH, low T4
C. High cortisol, low ACTH
D. Low insulin, high glucose
15. Which mediator primarily increases vascular permeability in acute inflammation?
A. Histamine
B. Aldosterone
C. Cortisol
D. Insulin
16. A patient with left-sided heart failure is most likely to develop:
A. Pulmonary edema
B. Peripheral edema only
C. JVD
D. Hepatomegaly
17. Which genetic mechanism is associated with cystic fibrosis?
A. Autosomal recessive CFTR mutation
B. Autosomal dominant mutation
C. X-linked mutation
D. Chromosomal trisomy
18. Which mechanism underlies Type 1 diabetes mellitus?
