NBME CBSE FINAL EXAM
QUESTIONS AND CORRECT ANSWERS |
| 100% GUARANTEED PASS <RECENT
VERSION>
How to prevent intracranial
hemorrhage in newborn - ANSWER ✅vit K
BPH tx - ANSWER ✅*finasteride* (5a red inhibitor)
*leuprolide* (GnRH)
*"-azosin"* (a1 block)
Finasteride - ANSWER ✅5a-reductase inhibitor
tx BPH and baldness
pulsatile Leuprolide - ANSWER ✅GnRH = rise LH/T
continuous Leuprolide - ANSWER ✅GnRH = decrease T/DHT
inhibit *androgen receptor binding* - ANSWER ✅flutamide
cyproterone
spironolactone
Leuprolide +
Antagonsist to androgen receptor - ANSWER ✅initial transient rise in LH/T from
leuprolide,
so administer with
*flutamide, cyproterone, spironolactone *
tx prostate cancer
"-azosin" - ANSWER ✅a1 block
tx BPH and HTN
, BPH can cause what on bladder - ANSWER ✅bladder outlet obstruction
--> parenchymal atrophy
--> CKD !!!
tx PCOS with - ANSWER ✅OCP
- suppress LH
- decrease androgen production
PCOS pt who wants to get pregnant - ANSWER ✅*Clomiphene*
- selective ER modulator
= prevent negative feedback
PCOS has a risk for what cancer - ANSWER ✅ENDOMETRIAL carcinoma
PCOS effect on thyroid - ANSWER ✅increase *TBG*
increase *total T4 *
NO CHANGE to TSH/T3
Bosentan - ANSWER ✅tx PAH
endothelin-R antagonist
Pre-Me treat with what for the lungs - ANSWER ✅dexamethasone
- increase surfactant by accelerating type II pneumo maturation
Latanoprost - ANSWER ✅tx open angle glaucoma (high IOP)
increase OUTFLOW of aqueous humor
treat psoriasis - ANSWER ✅vit D: *Calcipotriene; Calcitriol *
inhibit keratinocyte proliferation
stimulate differentitation
Ezetimibe - ANSWER ✅decrease cholesterol absorption at brush border by
inhibiting *NPC1L1* transporter
,myopathy can be caused from what liver/GI drugs - ANSWER ✅Statin + Fibrate
increase hepatocyte LDL-R recycling
What to check before starting *statin* - ANSWER ✅liver transaminase
What is typically used in a drug-eluting stent - ANSWER ✅statin
Rifaximin - ANSWER ✅antibiotic used to decrease
GI production/absorption of *NH3*
Acute Gout treatment - ANSWER ✅*NSAID* = 1st line
*Glucocorticoid *
*Colchicine*
- MT inhibitor (NO PMN migration)
What can precipitate gout - ANSWER ✅Large meal and alcohol
NIACIN !!!
flushing from PGE2 release
AE of colchicine - ANSWER ✅diarrhea
Methotrexate - ANSWER ✅folate antagonist
tx: cancer, RhA, Psoriasis,
Ectopic pregancy
reversal of MTX - ANSWER ✅folinic acid (*Leucovorin*)
What acts similarly to MTX
(but for bacteria) - ANSWER ✅*Trimethoprim *
- inhibit DHFR
(dihydrofolate reductase)
What drugs cause gynecomastia - ANSWER ✅Spironolactone
Ketoconazole
, Cimetidine (H2 block)
Estrogen, Steroid
Flutamide (Androgen R block)
Finasteride
Cromolyn - ANSWER ✅inhibit release of histamne from mast cell
prevent child asthma attacks
P450 substrates - ANSWER ✅*amitriptyline*
theophylline
*Warfarin*
tolbutamide
*Phenytoin*
*Statin*
Midazolam
E/P
P450 inhibitors - ANSWER ✅CRACK AMIGOS:
*Cimetidine*
Ritonarvir
*Amiodarone*
*Ciprofloxacin*
Ketoconazole
Acute alcohol use
*Macrolides*
*Isoniazid*
Grapefruit juice
Omeprazole
*Sulfonamides*
fluoxetine
P450 inducers - ANSWER ✅Quinidine
Barbiturates
*Phenytoin*
*Rifampin*
QUESTIONS AND CORRECT ANSWERS |
| 100% GUARANTEED PASS <RECENT
VERSION>
How to prevent intracranial
hemorrhage in newborn - ANSWER ✅vit K
BPH tx - ANSWER ✅*finasteride* (5a red inhibitor)
*leuprolide* (GnRH)
*"-azosin"* (a1 block)
Finasteride - ANSWER ✅5a-reductase inhibitor
tx BPH and baldness
pulsatile Leuprolide - ANSWER ✅GnRH = rise LH/T
continuous Leuprolide - ANSWER ✅GnRH = decrease T/DHT
inhibit *androgen receptor binding* - ANSWER ✅flutamide
cyproterone
spironolactone
Leuprolide +
Antagonsist to androgen receptor - ANSWER ✅initial transient rise in LH/T from
leuprolide,
so administer with
*flutamide, cyproterone, spironolactone *
tx prostate cancer
"-azosin" - ANSWER ✅a1 block
tx BPH and HTN
, BPH can cause what on bladder - ANSWER ✅bladder outlet obstruction
--> parenchymal atrophy
--> CKD !!!
tx PCOS with - ANSWER ✅OCP
- suppress LH
- decrease androgen production
PCOS pt who wants to get pregnant - ANSWER ✅*Clomiphene*
- selective ER modulator
= prevent negative feedback
PCOS has a risk for what cancer - ANSWER ✅ENDOMETRIAL carcinoma
PCOS effect on thyroid - ANSWER ✅increase *TBG*
increase *total T4 *
NO CHANGE to TSH/T3
Bosentan - ANSWER ✅tx PAH
endothelin-R antagonist
Pre-Me treat with what for the lungs - ANSWER ✅dexamethasone
- increase surfactant by accelerating type II pneumo maturation
Latanoprost - ANSWER ✅tx open angle glaucoma (high IOP)
increase OUTFLOW of aqueous humor
treat psoriasis - ANSWER ✅vit D: *Calcipotriene; Calcitriol *
inhibit keratinocyte proliferation
stimulate differentitation
Ezetimibe - ANSWER ✅decrease cholesterol absorption at brush border by
inhibiting *NPC1L1* transporter
,myopathy can be caused from what liver/GI drugs - ANSWER ✅Statin + Fibrate
increase hepatocyte LDL-R recycling
What to check before starting *statin* - ANSWER ✅liver transaminase
What is typically used in a drug-eluting stent - ANSWER ✅statin
Rifaximin - ANSWER ✅antibiotic used to decrease
GI production/absorption of *NH3*
Acute Gout treatment - ANSWER ✅*NSAID* = 1st line
*Glucocorticoid *
*Colchicine*
- MT inhibitor (NO PMN migration)
What can precipitate gout - ANSWER ✅Large meal and alcohol
NIACIN !!!
flushing from PGE2 release
AE of colchicine - ANSWER ✅diarrhea
Methotrexate - ANSWER ✅folate antagonist
tx: cancer, RhA, Psoriasis,
Ectopic pregancy
reversal of MTX - ANSWER ✅folinic acid (*Leucovorin*)
What acts similarly to MTX
(but for bacteria) - ANSWER ✅*Trimethoprim *
- inhibit DHFR
(dihydrofolate reductase)
What drugs cause gynecomastia - ANSWER ✅Spironolactone
Ketoconazole
, Cimetidine (H2 block)
Estrogen, Steroid
Flutamide (Androgen R block)
Finasteride
Cromolyn - ANSWER ✅inhibit release of histamne from mast cell
prevent child asthma attacks
P450 substrates - ANSWER ✅*amitriptyline*
theophylline
*Warfarin*
tolbutamide
*Phenytoin*
*Statin*
Midazolam
E/P
P450 inhibitors - ANSWER ✅CRACK AMIGOS:
*Cimetidine*
Ritonarvir
*Amiodarone*
*Ciprofloxacin*
Ketoconazole
Acute alcohol use
*Macrolides*
*Isoniazid*
Grapefruit juice
Omeprazole
*Sulfonamides*
fluoxetine
P450 inducers - ANSWER ✅Quinidine
Barbiturates
*Phenytoin*
*Rifampin*
