Biopharmaceutics (Blue PACOP)
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which factor primarily affects the rate of drug absorption from the gastrointestinal tract?
a. Molecular weight
✔✔ b. Surface area of absorption
c. Color of the drug
d. Brand name
Bioavailability refers to:
a. The fraction of drug metabolized in the liver
✔✔ b. The fraction of administered drug reaching systemic circulation unchanged
c. The rate of drug excretion
d. The protein binding percentage
Which route of drug administration avoids first-pass metabolism?
a. Oral
✔✔ b. Intravenous
1
,c. Rectal
d. Oral sustained-release
Which process describes the movement of drugs from the site of administration to systemic
circulation?
a. Distribution
b. Excretion
✔✔ c. Absorption
d. Metabolism
Which of the following is considered a rate-limiting step for poorly soluble drugs?
a. Blood flow
✔✔ b. Dissolution
c. Protein binding
d. Urinary excretion
The pH-partition hypothesis explains:
a. How drugs distribute into fat
2
,✔✔ b. How weak acids and bases cross membranes
c. How drugs are metabolized in the liver
d. How drugs bind to plasma proteins
Which factor increases the bioavailability of a drug?
a. Poor solubility
✔✔ b. High permeability
c. Extensive first-pass metabolism
d. Large molecular size
Volume of distribution (Vd) indicates:
✔✔ a. The extent of drug distribution in the body
b. The rate of renal excretion
c. The liver metabolism rate
d. Drug binding to albumin
Which type of drug crosses cell membranes primarily by passive diffusion?
a. Polar ionized molecules
3
, ✔✔ b. Lipid-soluble, non-ionized molecules
c. Large peptides
d. Proteins
The half-life of a drug is:
a. The time for absorption to complete
b. The time for excretion to start
✔✔ c. The time required for plasma drug concentration to decrease by 50%
d. The time to reach peak effect
Which of the following affects drug distribution?
a. Route of administration
✔✔ b. Plasma protein binding
c. Color of the tablet
d. Packaging
The term “first-pass effect” refers to:
✔✔ a. Metabolism of a drug by the liver before it reaches systemic circulation
4
Questions and Answers | Latest
Version | 2025/2026 | Correct & Verified
Which factor primarily affects the rate of drug absorption from the gastrointestinal tract?
a. Molecular weight
✔✔ b. Surface area of absorption
c. Color of the drug
d. Brand name
Bioavailability refers to:
a. The fraction of drug metabolized in the liver
✔✔ b. The fraction of administered drug reaching systemic circulation unchanged
c. The rate of drug excretion
d. The protein binding percentage
Which route of drug administration avoids first-pass metabolism?
a. Oral
✔✔ b. Intravenous
1
,c. Rectal
d. Oral sustained-release
Which process describes the movement of drugs from the site of administration to systemic
circulation?
a. Distribution
b. Excretion
✔✔ c. Absorption
d. Metabolism
Which of the following is considered a rate-limiting step for poorly soluble drugs?
a. Blood flow
✔✔ b. Dissolution
c. Protein binding
d. Urinary excretion
The pH-partition hypothesis explains:
a. How drugs distribute into fat
2
,✔✔ b. How weak acids and bases cross membranes
c. How drugs are metabolized in the liver
d. How drugs bind to plasma proteins
Which factor increases the bioavailability of a drug?
a. Poor solubility
✔✔ b. High permeability
c. Extensive first-pass metabolism
d. Large molecular size
Volume of distribution (Vd) indicates:
✔✔ a. The extent of drug distribution in the body
b. The rate of renal excretion
c. The liver metabolism rate
d. Drug binding to albumin
Which type of drug crosses cell membranes primarily by passive diffusion?
a. Polar ionized molecules
3
, ✔✔ b. Lipid-soluble, non-ionized molecules
c. Large peptides
d. Proteins
The half-life of a drug is:
a. The time for absorption to complete
b. The time for excretion to start
✔✔ c. The time required for plasma drug concentration to decrease by 50%
d. The time to reach peak effect
Which of the following affects drug distribution?
a. Route of administration
✔✔ b. Plasma protein binding
c. Color of the tablet
d. Packaging
The term “first-pass effect” refers to:
✔✔ a. Metabolism of a drug by the liver before it reaches systemic circulation
4
