Biopharmaceutics (Green PACOP) Questions and Answers | Latest Version | 2025/2026 | Correct & Verified

Biopharmaceutics (Green PACOP) Questions and Answers | Latest Version | 2025/2026 | Correct & Verified Which pharmacokinetic phase involves the movement of drug from the site of administration into the bloodstream? a. Distribution b. Absorption c. Metabolism d. Elimination The process by which a drug is converted into more water-soluble metabolites is: a. Absorption b. Distribution c. Biotransformation d. Excretion Which pharmacokinetic parameter represents the total extent of drug exposure in plasma over time? 2 a. Cmax b. AUC c. Tmax d. Kel What does bioavailability refer to? a. Drug binding to plasma proteins b. Rate of renal clearance c. Fraction of administered drug reaching systemic circulation d. Degree of drug metabolism in the liver Which is the primary organ of drug metabolism? a. Kidney b. Liver c. Lungs d. Spleen Which order of kinetics is most common for therapeutic drugs at normal concentrations? 3 a. First-order b. Zero-order c. Saturable d. Mixed-order If two drug formulations produce superimposable plasma concentration–time curves, they are considered: a. Therapeutically equivalent b. Bioequivalent c. Pharmacologically antagonistic d. Biotransformed What does Cmax indicate in a plasma concentration–time profile? a. Peak plasma concentration b. Half-life of the drug c. Rate of renal clearance d. Total body exposure 4 Which factor delays gastric emptying and reduces drug absorption rate? a. High-fat meals b. Water intake c. Fasting state d. Alkaline urine Which route of administration avoids first-pass metabolism? a. Oral b. Rectal (upper part) c. Sublingual d. Gastric The plasma half-life (t1⁄2) of a drug primarily depends on: a. Absorption rate b. Clearance and volume of distribution c. Bioavailability d. Protein binding only 5 Which of the following increases the bioavailability of a weakly basic drug? a. Acidic urine b. Alkaline urine c. Increased gastric emptying d. High plasma protein binding