Psychopharmacology Final Exam
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The process of releasing neurotransmitter molecules from the vesicles
is known as _____ and occurs as a result of an influx of _____
Ans: Exocytosis; Ca2+
Depot binding is said to occur when drugs
Ans: Bind to inactive sites
During the ____ period, no additional action potentials can be created
Ans: Absolute refractory
Neural transmission is generally ____ within a single neuron and ____
between neurons.
Ans: Electrical; chemical
The most common type of synapse in the brain is the ______ synapse
Ans: Axodendritic
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Neurons rely on ____ for protection, metabolic support and insulation
Ans: Glial cells
Which of the following factors does NOT affect the pharmokinetics of
a drug?
A) Route of Administration
B) Lipid solubility
C) Depot binding
D) Drug action
Ans: Drug action
The sac-like structures in the presynaptic terminal are called ______
and are filled with _______
Ans: Synaptic vesicles; neurotransmitter molecules
In addition to environmental and sensory stimuli, psychoactive drugs
can trigger long-lasting changes in neuronal connectivity. Collectively,
these changes are termed
Ans: Synaptic plasticity
Axonal transport of proteins occurs along a track formed by
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Ans: Microtubules
When activated, somatodendritic autoreceptors
Ans: Reduce the rate of cell firing
If a substance is a neurotransmitter, stimulation of the presynaptic cell
should have the same effect as
Ans: Direct application of the proposed substance to the
postsynaptic cell
In order for a substance to be considered a neurotransmitter it must
meet several criteria. Which of the following is NOT considered a
criterion for neurotransmitter status?
A) A synthetic mechanism should be present in the presynaptic cell
B) Vesicles containing the substance should move down the axon with
the action potentials when the neuron is stimulated
C) Receptors for the proposed substance should be present on the
postsynaptic cell
D) A means for inactivating the substance should be present
Ans: Vesicles containing the substance should move down the
axon with the action potentials when the neuron is stimulated
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The Na+/K+ pump helps to maintain the ______ by moving three Na+
ions in and two K+ ions out of the cell
Ans: Resting membrane potential
Activating a metabotropic receptor can result in all of the following
except for
A) Opening of a G protein-gated ion channel
B) changes in the levels of a second messenger
C)Opening of an ion channel within the receptor
D) Changes in gene expression
Ans: Changes in gene expression
Drug metabolism mostly occurs in the ____ and usually makes a drug
more _____ soluble.
Ans: Liver; Water
The ____ is best described as a result of the selective permeability of
the neuronal membrane and the uneven distribution of ions inside and
outside the cell.
Ans: Resting membrane potential
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