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Antacids MOA - 🧠 ANSWER ✔✔• Inorganic salts that neutralize
hydrochloric acid to increase gastric pH above 4.0.
Antacids Indication - 🧠 ANSWER ✔✔• Provide the quickest relief, b/c they
work on the stomach acid already present.
• Good for acute gastric distress.
• Often the 1st thing tried by patients with GERD & Peptic Ulcer Disease,
but ineffective for persistent GERD & PUD.
Antacids Examples - 🧠 ANSWER ✔✔• Calcium Carbonate (Tums)
• Sodium Bicarbonate (Alka-seltzer)
• Magnesium Hydroxide (Milk of Magnesia)
,• Aluminum Hydroxide (Amphojel)
Antacids Potential Side effects - 🧠 ANSWER ✔✔• Diarrhea
• Constipation
Antacid Side effects Calcium Carbonate (Tums), Aluminum
(Salts/Hydroxide): - 🧠 ANSWER ✔✔• Constipation
• Increased risk for kidney stones
Antacid Side effect Sodium Bicarbonate (Alka-seltzer) - 🧠 ANSWER ✔✔•
sodium - increased HTN
• Aspirin - worsened GI distress
*Remember: b/c of ASA don't use in pregnancy*
Antacid Side effect Milk of Magnesia - 🧠 ANSWER ✔✔• Diarrhea
*Do NOT give w/renal Insufficiency*
Primary Care Art of prescribing: - 🧠 ANSWER ✔✔When ordering Pay
attention to how side effects of each antacid will affect your patient's
current medical conditions & problems-use them to patient's advantage.
,Art of Prescribing examples - 🧠 ANSWER ✔✔• Osteoporosis - patient
benefits from Calcium carbonate.
• Pt. with hx of Diarrhea harmed would not do well with Milk of mag.
• Constipated- MOM will improve their constipation
Antacids: Potential Drug to Drug interaction: - 🧠 ANSWER ✔✔• May alter
the absorption of drugs dependent on acidic gastric pH
• ↓ses the absorption of Iron & Prenatal vitamins - should not co-administer.
• Aluminum Hydroxide - Warfarin: ↓ses warfarin absorption
Why Antacids should not be co-administered with Enteric-coated drugs. - 🧠
ANSWER ✔✔enteric coating prevents the medication from being broken
down the the acidic stomach, so it can make it to the intestine & breakdown
in the alkaline pH. Reducing the acidity of the stomach causes the drug to
be broken down prematurely. Timing of administration should be
determined to prevent absorption of in the stomach.
Antacids Contraindication - 🧠 ANSWER ✔✔• Renal insufficiency - avoid
Milk of Mag (leads to hypermagnesemia) &
• Renal insufficiency- avoid Aluminum Salts (worsens kidney function)
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, • Cardiovascular disease - avoid Sodium bicarbonate ↑ HTN
Antacids Patient Education: - 🧠 ANSWER ✔✔• Take 1-3 hours after meals
& at bedtime.
• Do not take Calcium based with foods containing Oxalic acid (spinach,
rhubarb) or phytic acid (bran, cereals) - decreases absorption of the
Calcium.
• May worsen osteoporosis due to decreased absorption of nutrients (non
Calcium based antacids)
Antacids Sodium Bicarbonate Pregnancy considerations - 🧠 ANSWER ✔✔•
contraindicated - contains Aspirin.
• ↑ses risk of maternal or fetal metabolic alkalosis & fluid overload.
Antacids Aluminum Hydroxide Pregnancy considerations - 🧠 ANSWER ✔✔-
do not use as first line. (not contraindicated, but use Calcium or Magnesium
based antacids first)
Antacids Magnesium-based antacids Pregnancy considerations - 🧠
ANSWER ✔✔• the most frequently used.
• May help relieve constipation.