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Exam (elaborations)

PC 707 – 100 Exam Questions on GERD, PUD, IBS & Pharmacologic Therapy | 2025

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This resource contains 100 comprehensive, exam-focused questions and answers for PC 707 – Clinical Pharmacology (Module 3), specifically targeting gastrointestinal disorders and their treatment. It covers essential therapeutic strategies for managing GERD, peptic ulcer disease (PUD), irritable bowel syndrome (IBS), constipation, diarrhea, nausea and vomiting, as well as the pharmacokinetics, side effects, contraindications, and clinical decision-making behind prescribing commonly used medications. The content includes detailed comparisons and clinical applications of antacids, H2-receptor antagonists, proton pump inhibitors (PPIs), prostaglandin analogs, antiemetics, laxatives, and anti-diarrheals. Special attention is given to drug interactions, pregnancy and lactation safety, pediatric and geriatric use, and stepwise treatment approaches (e.g., for GERD or nausea in pregnancy). Additional coverage includes integrative options like probiotics, peppermint oil, FODMAP diet, and CAM therapies. The document is structured with real-world clinical applications in mind, ideal for mastering board-level questions and clinical prescribing principles. Suitable for: Nurse Practitioner students in PC 707 or similar Advanced Pharmacology courses MSN, DNP, or Post-Master’s certificate students focusing on primary or family care Medical students and PA students preparing for GI system exams Candidates preparing for national board certification (AANP, ANCC, PANCE) Clinical instructors seeking comprehensive review material for GI pharmacology Keywords: GERD, PUD, IBS, antacids, H2 blockers, proton pump inhibitors, sucralfate, misoprostol, GI pharmacology, diarrhea treatment, constipation treatment, antiemetics, ondansetron, metoclopramide, phenothiazines, pregnancy-safe medications, lactation safety, drug interactions, GI cocktail, stepwise therapy, IBS management, FODMAP diet, probiotics, CAM therapies, prescribing safety, pharmacokinetics, board exam prep

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Uploaded on
September 26, 2025
Number of pages
53
Written in
2025/2026
Type
Exam (elaborations)
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PC 707 Module 3 2025/2026 Exam
Questions with 100% Correct Answers |
Latest Update



Antacids MOA - 🧠 ANSWER ✔✔• Inorganic salts that neutralize

hydrochloric acid to increase gastric pH above 4.0.


Antacids Indication - 🧠 ANSWER ✔✔• Provide the quickest relief, b/c they

work on the stomach acid already present.

• Good for acute gastric distress.

• Often the 1st thing tried by patients with GERD & Peptic Ulcer Disease,

but ineffective for persistent GERD & PUD.


Antacids Examples - 🧠 ANSWER ✔✔• Calcium Carbonate (Tums)


• Sodium Bicarbonate (Alka-seltzer)

• Magnesium Hydroxide (Milk of Magnesia)

,• Aluminum Hydroxide (Amphojel)


Antacids Potential Side effects - 🧠 ANSWER ✔✔• Diarrhea


• Constipation

Antacid Side effects Calcium Carbonate (Tums), Aluminum

(Salts/Hydroxide): - 🧠 ANSWER ✔✔• Constipation


• Increased risk for kidney stones


Antacid Side effect Sodium Bicarbonate (Alka-seltzer) - 🧠 ANSWER ✔✔•

sodium - increased HTN

• Aspirin - worsened GI distress

*Remember: b/c of ASA don't use in pregnancy*


Antacid Side effect Milk of Magnesia - 🧠 ANSWER ✔✔• Diarrhea


*Do NOT give w/renal Insufficiency*


Primary Care Art of prescribing: - 🧠 ANSWER ✔✔When ordering Pay

attention to how side effects of each antacid will affect your patient's

current medical conditions & problems-use them to patient's advantage.

,Art of Prescribing examples - 🧠 ANSWER ✔✔• Osteoporosis - patient

benefits from Calcium carbonate.

• Pt. with hx of Diarrhea harmed would not do well with Milk of mag.

• Constipated- MOM will improve their constipation


Antacids: Potential Drug to Drug interaction: - 🧠 ANSWER ✔✔• May alter

the absorption of drugs dependent on acidic gastric pH

• ↓ses the absorption of Iron & Prenatal vitamins - should not co-administer.

• Aluminum Hydroxide - Warfarin: ↓ses warfarin absorption

Why Antacids should not be co-administered with Enteric-coated drugs. - 🧠

ANSWER ✔✔enteric coating prevents the medication from being broken

down the the acidic stomach, so it can make it to the intestine & breakdown

in the alkaline pH. Reducing the acidity of the stomach causes the drug to

be broken down prematurely. Timing of administration should be

determined to prevent absorption of in the stomach.


Antacids Contraindication - 🧠 ANSWER ✔✔• Renal insufficiency - avoid

Milk of Mag (leads to hypermagnesemia) &

• Renal insufficiency- avoid Aluminum Salts (worsens kidney function)



COPYRIGHT©NINJANERD 2025/2026. YEAR PUBLISHED 2025. COMPANY REGISTRATION NUMBER: 619652435. TERMS OF USE. PRIVACY
STATEMENT. ALL RIGHTS RESERVED
3

, • Cardiovascular disease - avoid Sodium bicarbonate ↑ HTN


Antacids Patient Education: - 🧠 ANSWER ✔✔• Take 1-3 hours after meals

& at bedtime.

• Do not take Calcium based with foods containing Oxalic acid (spinach,

rhubarb) or phytic acid (bran, cereals) - decreases absorption of the

Calcium.

• May worsen osteoporosis due to decreased absorption of nutrients (non

Calcium based antacids)


Antacids Sodium Bicarbonate Pregnancy considerations - 🧠 ANSWER ✔✔•

contraindicated - contains Aspirin.

• ↑ses risk of maternal or fetal metabolic alkalosis & fluid overload.


Antacids Aluminum Hydroxide Pregnancy considerations - 🧠 ANSWER ✔✔-

do not use as first line. (not contraindicated, but use Calcium or Magnesium

based antacids first)

Antacids Magnesium-based antacids Pregnancy considerations - 🧠

ANSWER ✔✔• the most frequently used.


• May help relieve constipation.

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