NEW!
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
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KATZUNG TREVOR TEST BANK
z z z z
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS
z z z z z z z
, Page 2 of 822 z z z
Basicand Clinical Pharmacology 15th EditionKatzungTrevor Test Bank
z z z z z z z z z
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
z z z z z z z z z z z
1. A nurse working in radiology administers iodine to a patient who is having a
z z z z z z z z z z z z z
computed tomography (CT) scan. The nurse working on the oncology unit
z z z z z z z z z z z
administers chemotherapy to patients who have cancer. At the Public Health
z z z z z z z z z z z
Department, a nurse administers a measles-mumps-rubella (MMR) vaccine to a
z z z z z z z z z z
14-month-old child as a routine immunization. Which branch of pharmacology
z z z z z z z z z z
best describes the actions of all three nurses?
z z z z z z z z
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are
z z z z z z z z z z z
involved with clinical pharmacology or pharmacotherapeutics, which is a
z z z z z z z z z
branch of pharmacology that deals with the uses of drugs to treat, prevent, and
z z z z z z z z z z z z z z
diagnose disease. The radiology nurse is administering a drug to help diagnose
z z z z z z z z z z z z
a disease. The oncology nurse is administering a drug to help treat a disease.
z z z z z z z z z z z z z z
Pharmacoeconomics includes any costs involved in drug therapy.
z z z z z z z z
Pharmacodynamics involves how a drug affects the body and pharmacokinetics z z z z z z z z z
is how the body acts on the body.
z z z z z z z z
2. When involved in phase III drug evaluation studies, what
z z z z z z z z
responsibilities would the nurse have?
z z z z z
A) Working with animals who are given experimental drugs
z z z z z z z
B) Choosing appropriate patients to be involved in the drug study
z z z z z z z z z
C) Monitoring and observing patients closely for adverse effects
z z z z z z z
D) Conducting research to determine effectiveness of the drug
z z z z z z z
, Page 3 of 822 z z z
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which
z z z z z z z z z z z z z z
patients are asked to record any symptoms they experience while taking the
z z z z z z z z z z z z
drugs. Nurses may be responsible for helping collect and analyze the
z z z z z z z z z z z
information to be shared with the Food and Drug Administration (FDA) but
z z z z z z z z z z z z
would not conduct research independently because nurses do not prescribe
z z z z z z z z z z
medications. Use of animals in drug testing is done in the preclinical trials.
z z z z z z z z z z z z z
Select patients who are involved in phase II studies to participate in studies
z z z z z z z z z z z z z
where the participants have the disease the drug is intended to treat. These
z z z z z z z z z z z z z
patients are monitored closely for drug action and adverse effects. Phase I
z z z z z z z z z z z z
studies involve healthy human volunteers who are usually paid for their
z z z z z z z z z z z
participation. Nurses may observe for adverse effects and toxicity.
z z z z z z z z z
3. A physician has ordered intramuscular (IM) injections of morphine, a
z z z z z z z z z
narcotic, every 4 hours as needed for pain in a motor vehicle accident victim.
z z z z z z z z z z z z z z
The nurse is aware this drug has a high abuse potential. Under what category
z z z z z z z z z z z z z z
would morphine be classified?
z z z z
A) Schedule I z
B) Schedule II z
C) Schedule III z
D) Schedule IV z
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs
z z z z z z z z z z z
because of severe dependence liability. Schedule I drugs have high abuse
z z z z z z z z z z z
potential and no accepted medical use. Schedule III drugs have a lesser abuse
z z z z z z z z z z z z z
potential than II and an accepted medical use. Schedule IV drugs have low
z z z z z z z z z z z z z
abuse potential and limited dependence liability.
z z z z z z
4. What concept is considered when generic drugs are substituted for brand
z z z z z z z z z z
name drugs?
z z
A) Bioavailability
WWW.THENURSINGMASTERY.
www.stuvia.com
, Page 4 of 822 z z z
B) Critical concentration z
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic z z z z z z z z z z z z z
circulation and is available to act on body cells. Binders used in a generic
z z z z z z z z z z z z z z
drug may not be the same as those used in the brand name drug. Therefore,
z z z z z z z z z z z z z z z
the way the body breaks down and uses the drug may differ, which may
z z z z z z z z z z z z z z
eliminate a generic drug substitution. Critical concentration is the amount of a
z z z z z z z z z z z z
drug that is needed to cause a therapeutic effect and should not differ between
z z z z z z z z z z z z z z
generic and brand name medications. Distribution is the phase of
z z z z z z z z z z
pharmacokinetics, which involves the movement of a drug to the bodys
z z z z z z z z z z z
tissues and is the same in generic and brand name drugs. A drugs half-life is the
z z z z z z z z z z z z z z z z
time it takes for the amount of drug to decrease to half the peak level, which
z z z z z z z z z z z z z z z z
should not change when substituting a generic medication.
z z z z z z z z
5. A nurse is assessing the patients home medication use. After listening to the
z z z z z z z z z z z z
patient list current medications, the nurse asks what priority question?
z z z z z z z z z z
A) Do you take any generic medications?
z z z z z
B) Are any of these medications orphan drugs?
z z z z z z
C) Are these medications safe to take during pregnancy?
z z z z z z z
D) Do you take any over-the-counter medications?
z z z z z
Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-counter
z z z z z z z z z z z
medications because patients may not consider them important. The patient is
z z z z z z z z z z z
unlikely to know the meaning of orphan drugs unless they too are health care
z z z z z z z z z z z z z z
providers. Safety during pregnancy, use of a generic medication, or
z z z z z z z z z z
classification of orphan drugs are things the patient would be unable to answer
z z z z z z z z z z z z z
but could be found in reference books if the nurse wishes to research them.
z z z z z z z z z z z z z z
WWW.THENURSINGMASTERY.
www.stuvia.com
BASIC AND CLINICAL PHARMACOLOGY 15TH EDITION
z z z z z
KATZUNG TREVOR TEST BANK
z z z z
INCLUSIVE OF CHAPTERS 1-66 COMPLETE WITH EXPLAINED ANSWERS
z z z z z z z
, Page 2 of 822 z z z
Basicand Clinical Pharmacology 15th EditionKatzungTrevor Test Bank
z z z z z z z z z
Chapter 1. Introduction: The Nature of Drugs & Drug Development & Regulation
z z z z z z z z z z z
1. A nurse working in radiology administers iodine to a patient who is having a
z z z z z z z z z z z z z
computed tomography (CT) scan. The nurse working on the oncology unit
z z z z z z z z z z z
administers chemotherapy to patients who have cancer. At the Public Health
z z z z z z z z z z z
Department, a nurse administers a measles-mumps-rubella (MMR) vaccine to a
z z z z z z z z z z
14-month-old child as a routine immunization. Which branch of pharmacology
z z z z z z z z z z
best describes the actions of all three nurses?
z z z z z z z z
A) Pharmacoeconomics
B) Pharmacotherapeutics
C) Pharmacodynamics
D) Pharmacokinetics
Ans: B
Feedback:
Pharmacology is the study of the biologic effects of chemicals. Nurses are
z z z z z z z z z z z
involved with clinical pharmacology or pharmacotherapeutics, which is a
z z z z z z z z z
branch of pharmacology that deals with the uses of drugs to treat, prevent, and
z z z z z z z z z z z z z z
diagnose disease. The radiology nurse is administering a drug to help diagnose
z z z z z z z z z z z z
a disease. The oncology nurse is administering a drug to help treat a disease.
z z z z z z z z z z z z z z
Pharmacoeconomics includes any costs involved in drug therapy.
z z z z z z z z
Pharmacodynamics involves how a drug affects the body and pharmacokinetics z z z z z z z z z
is how the body acts on the body.
z z z z z z z z
2. When involved in phase III drug evaluation studies, what
z z z z z z z z
responsibilities would the nurse have?
z z z z z
A) Working with animals who are given experimental drugs
z z z z z z z
B) Choosing appropriate patients to be involved in the drug study
z z z z z z z z z
C) Monitoring and observing patients closely for adverse effects
z z z z z z z
D) Conducting research to determine effectiveness of the drug
z z z z z z z
, Page 3 of 822 z z z
Ans: C
Feedback:
Phase III studies involve use of a drug in a vast clinical population in which
z z z z z z z z z z z z z z
patients are asked to record any symptoms they experience while taking the
z z z z z z z z z z z z
drugs. Nurses may be responsible for helping collect and analyze the
z z z z z z z z z z z
information to be shared with the Food and Drug Administration (FDA) but
z z z z z z z z z z z z
would not conduct research independently because nurses do not prescribe
z z z z z z z z z z
medications. Use of animals in drug testing is done in the preclinical trials.
z z z z z z z z z z z z z
Select patients who are involved in phase II studies to participate in studies
z z z z z z z z z z z z z
where the participants have the disease the drug is intended to treat. These
z z z z z z z z z z z z z
patients are monitored closely for drug action and adverse effects. Phase I
z z z z z z z z z z z z
studies involve healthy human volunteers who are usually paid for their
z z z z z z z z z z z
participation. Nurses may observe for adverse effects and toxicity.
z z z z z z z z z
3. A physician has ordered intramuscular (IM) injections of morphine, a
z z z z z z z z z
narcotic, every 4 hours as needed for pain in a motor vehicle accident victim.
z z z z z z z z z z z z z z
The nurse is aware this drug has a high abuse potential. Under what category
z z z z z z z z z z z z z z
would morphine be classified?
z z z z
A) Schedule I z
B) Schedule II z
C) Schedule III z
D) Schedule IV z
Ans: B
Feedback:
Narcotics with a high abuse potential are classified as Schedule II drugs
z z z z z z z z z z z
because of severe dependence liability. Schedule I drugs have high abuse
z z z z z z z z z z z
potential and no accepted medical use. Schedule III drugs have a lesser abuse
z z z z z z z z z z z z z
potential than II and an accepted medical use. Schedule IV drugs have low
z z z z z z z z z z z z z
abuse potential and limited dependence liability.
z z z z z z
4. What concept is considered when generic drugs are substituted for brand
z z z z z z z z z z
name drugs?
z z
A) Bioavailability
WWW.THENURSINGMASTERY.
www.stuvia.com
, Page 4 of 822 z z z
B) Critical concentration z
C) Distribution
D) Half-life
Ans: A
Feedback:
Bioavailability is the portion of a dose of a drug that reaches the systemic z z z z z z z z z z z z z
circulation and is available to act on body cells. Binders used in a generic
z z z z z z z z z z z z z z
drug may not be the same as those used in the brand name drug. Therefore,
z z z z z z z z z z z z z z z
the way the body breaks down and uses the drug may differ, which may
z z z z z z z z z z z z z z
eliminate a generic drug substitution. Critical concentration is the amount of a
z z z z z z z z z z z z
drug that is needed to cause a therapeutic effect and should not differ between
z z z z z z z z z z z z z z
generic and brand name medications. Distribution is the phase of
z z z z z z z z z z
pharmacokinetics, which involves the movement of a drug to the bodys
z z z z z z z z z z z
tissues and is the same in generic and brand name drugs. A drugs half-life is the
z z z z z z z z z z z z z z z z
time it takes for the amount of drug to decrease to half the peak level, which
z z z z z z z z z z z z z z z z
should not change when substituting a generic medication.
z z z z z z z z
5. A nurse is assessing the patients home medication use. After listening to the
z z z z z z z z z z z z
patient list current medications, the nurse asks what priority question?
z z z z z z z z z z
A) Do you take any generic medications?
z z z z z
B) Are any of these medications orphan drugs?
z z z z z z
C) Are these medications safe to take during pregnancy?
z z z z z z z
D) Do you take any over-the-counter medications?
z z z z z
Ans: D
Feedback:
It is important for the nurse to specifically question use of over-the-counter
z z z z z z z z z z z
medications because patients may not consider them important. The patient is
z z z z z z z z z z z
unlikely to know the meaning of orphan drugs unless they too are health care
z z z z z z z z z z z z z z
providers. Safety during pregnancy, use of a generic medication, or
z z z z z z z z z z
classification of orphan drugs are things the patient would be unable to answer
z z z z z z z z z z z z z
but could be found in reference books if the nurse wishes to research them.
z z z z z z z z z z z z z z
WWW.THENURSINGMASTERY.
www.stuvia.com
