Exam Questions And 100% Accurate
Answers 2025.
Pathogenesis of osteoarthritis - Answer degenerative disease of cartilage (chondrocytes and
matrix)
Clinical Features of OA - Answer Joint Pain- deep aching pain aggravated by motion and
weight bearing; sometimes worse at night after day of
vigorous activity
• Joint stiffness, esp. after periods of inactivity
• Joint enlargement of osteophyte formation
• Crepitus on movement with joint
• Later stages, pain on motion and at rest, limitation of
motion, mal-alignment, bony protuberances from spurs
Joints more commonly affected by osteoarthritis - Answer Knees, Hips, Hands, Spine
Major radiographic features of OA - Answer Joint space narrowing (best predicts disease
progression)
Subchondral sclerosis (hardening of tissue beneath the cartilage)
Osteophytes/bone spurs - patellofemoral and tibiofemoral joint osteophytes correlate best with
pain)
Subchondral cysts (fluid filled sacs in the bone marrow)
rheumatoid arthritis (RA) - Answer chronic systemic disease characterized by autoimmune
inflammatory changes in the connective tissue throughout the body
S/S of RA - Answer Primarily manifested by synovitis and destructive
arthritis of the diarthrodial joints; fingers (MCP,
PIP) wrist, shoulders, knees
• Affected joints are painful to pressure (tender),
, • Pain, tenderness, warmth, swelling
• Fatigue -chest pain with deep inspiration
• Depression -low grade fever
• Malaise -painful eyes
• Anorexia
Diagnostic Pearls for RA - Answer Persistent, symmetric polyarthritis
• Presence of systemic features
• Presence of rheumatoid nodules
• Exclusion of other systemic disorders
Morning stiffness for >6 weeks
• Arthritis involving 3 or more joints for > 6
weeks
• Arthritis of hand joints > 6 weeks
• Rheumatoid nodules
Gout - Answer Metabolic disorder influenced by dietary
factors—overeating, obesity, alcohol abuse,
hyperlipidemia and insulin resistance
syndrome
Develops when uric acid crystals collect in
the synovial fluid
Purine Rich Foods - Answer Organ meats and other meats
• Anchovies
• Sardines
• Meat extracts--gravy, broth, bouillon
S/S of Gout - Answer 1. Complaint of pain occurring at night involving the great toe or other
joints
2. Signs of edema, heat, discoloration and limited movement in joints