Peptic Ulcer Disease
Key Concepts
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NR 507: Week 5 Edapt: Peptic Ulcer Disease
PUD is commonly associated with Helicobacter pylori (H. pylori) bacterial infection. H. pylori can colonize the gastric
mucosa, leading to chronic inflammation and disruption of the mucosal barrier. This can result in increased acid
secretion, impaired mucus production, and the development of ulcers.
Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen are well-known risk factors for PUD. Regular and
prolonged use of NSAIDs can interfere with the protective mechanisms of the gastrointestinal mucosa, leading to the
development of ulcers.
Excessive alcohol consumption is a recognized risk factor for PUD. Alcohol can irritate the gastric mucosa and
increase the production of gastric acid, contributing to the development of ulcers.
Advancing age is associated with an increased risk of PUD. Older individuals may experience changes in the
mucosal lining of the stomach that make them more susceptible to ulcers.
A family history of PUD suggests a potential genetic predisposition. Genetic factors may influence an individual's
susceptibility to developing ulcers.
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