ASCP Hematology Review UPDATED ACTUAL Questions and
CORRECT Answers
1. Name the locations of active marrow in sternum, skull, ribs, pelvis, vertebrae
adults:
2. Where does hematopoiesis take place yolk sac
during the first 2 months of gestation?
3. Where does the majority of spleen
hematopoiesis take place during the 2nd
through 7th month of gestation?
4. When does the bone marrow take over after birth
hematopoiesis?
5. What are the stages in order of the ery- (1)rubriblast, (2)prorubricyte, (3)rubricyte,
throcyte lineage? (4)metarubricyte, (5)reticulocyte, (6)erytro-
cyte
6. What are the stages in order of the gran- (1)myeloblast, (2)promyelocyte, (3)myelocyte,
ulocyte (neutrophil, eosinophil, basophil) (4)metamyelocyte, (5)band, (6)segmented
lineage? (7)eos/baso
7. What are the stages in order of the (1)monoblast, (2)promonocyte, (3)monocyte,
macrophage lineage? (4)macrophage
8. What are the stages in order of the (1)megakaryoblast, (2)promegakaryocyte,
platelet lineage? (3)megakaryocyte, (4)platelet
9. What are the stages in order of the lym- (1)lymphoblast, (2)prolymphocyte, (3)lym-
phocyte lineage? phocyte
10. Which growth factors stimulate the ery- GM-CSF, EPO, IL-3
throcyte lineage?
11. GM-CSF, IL-3
, ASCP Hematology Review UPDATED ACTUAL Questions and
CORRECT Answers
Which growth factors stimulate the gran-
ulocyte lineages?
12. Which growth factors stimulate the GM-CSF, IL-3, TPO
platelet lineage?
13. Which growth factors stimulate the lym- IL-2, IL-4, IL-6, IL-7
phocyte lineage?
14. Which protein functions in the transport transferrin
of Fe?
15. What is the major storage form of Fe? ferritin
16. What is the long-term (H20) insoluble Fe hemosiderin
storage form called?
17. Excess Iron is stored where? What does tissues and body organs, hemosiderosis, he-
this cause? mochromatosis
18. Porphyrias are attributed to? excessive formation of porphrins due to block-
ages in any enzymatic step in the heme syn-
thesis pathway.
19. Red or port wine colored urine can be porphyria
seen in which condition related to the
build up of heme precursors?
20. Neuropsychiatirc symptoms are seen early precursors (Delta-aminolevulinic
when a build up of which precursors oc- acid/Porphobilinogen)
curs?
21. Cutaneous symptoms such as pho- later precursors (uroporphyrinogen/copro-
to-sensitivity and facial hair are seen porphyrinogen, protoporphyrin/heme)
, ASCP Hematology Review UPDATED ACTUAL Questions and
CORRECT Answers
when a build up of which precursors oc-
curs?
22. Synthesis of heme requires what two iron, protoporphyrin
components?
23. What are the heme precursors in order (1)delta-aminolevulinic acid, (2)porpho-
of synthesis? bilinogen, (3)uroporphyrinogen, (4)copro-
porphyrinogen, (5)protoporphyrin, (6)heme
24. What type of hemoglobin is seen primar- Hgb F
ily in newborns?
25. What type of hemoglobin is seen primar- Hgb A2
ily in adults?
26. What type of hemoglobin is rarely seen Hgb A
in adults as well as newborns?
27. What hemoglobin types are seen in em- gower I, gower II, portland
bryos but not in adults or newborns?
28. All non-embryonic hemoglobin types are alpha
comprised of what type of globin chain?
29. Hemoglobin A2 is composed of what alpha, beta
types of globin chains?
30. Hemoglobin A is composed of what alpha, delta
types of globin chains?
31. Hemoglobin F is composed of what types alpha, gamma
of globin chains?
CORRECT Answers
1. Name the locations of active marrow in sternum, skull, ribs, pelvis, vertebrae
adults:
2. Where does hematopoiesis take place yolk sac
during the first 2 months of gestation?
3. Where does the majority of spleen
hematopoiesis take place during the 2nd
through 7th month of gestation?
4. When does the bone marrow take over after birth
hematopoiesis?
5. What are the stages in order of the ery- (1)rubriblast, (2)prorubricyte, (3)rubricyte,
throcyte lineage? (4)metarubricyte, (5)reticulocyte, (6)erytro-
cyte
6. What are the stages in order of the gran- (1)myeloblast, (2)promyelocyte, (3)myelocyte,
ulocyte (neutrophil, eosinophil, basophil) (4)metamyelocyte, (5)band, (6)segmented
lineage? (7)eos/baso
7. What are the stages in order of the (1)monoblast, (2)promonocyte, (3)monocyte,
macrophage lineage? (4)macrophage
8. What are the stages in order of the (1)megakaryoblast, (2)promegakaryocyte,
platelet lineage? (3)megakaryocyte, (4)platelet
9. What are the stages in order of the lym- (1)lymphoblast, (2)prolymphocyte, (3)lym-
phocyte lineage? phocyte
10. Which growth factors stimulate the ery- GM-CSF, EPO, IL-3
throcyte lineage?
11. GM-CSF, IL-3
, ASCP Hematology Review UPDATED ACTUAL Questions and
CORRECT Answers
Which growth factors stimulate the gran-
ulocyte lineages?
12. Which growth factors stimulate the GM-CSF, IL-3, TPO
platelet lineage?
13. Which growth factors stimulate the lym- IL-2, IL-4, IL-6, IL-7
phocyte lineage?
14. Which protein functions in the transport transferrin
of Fe?
15. What is the major storage form of Fe? ferritin
16. What is the long-term (H20) insoluble Fe hemosiderin
storage form called?
17. Excess Iron is stored where? What does tissues and body organs, hemosiderosis, he-
this cause? mochromatosis
18. Porphyrias are attributed to? excessive formation of porphrins due to block-
ages in any enzymatic step in the heme syn-
thesis pathway.
19. Red or port wine colored urine can be porphyria
seen in which condition related to the
build up of heme precursors?
20. Neuropsychiatirc symptoms are seen early precursors (Delta-aminolevulinic
when a build up of which precursors oc- acid/Porphobilinogen)
curs?
21. Cutaneous symptoms such as pho- later precursors (uroporphyrinogen/copro-
to-sensitivity and facial hair are seen porphyrinogen, protoporphyrin/heme)
, ASCP Hematology Review UPDATED ACTUAL Questions and
CORRECT Answers
when a build up of which precursors oc-
curs?
22. Synthesis of heme requires what two iron, protoporphyrin
components?
23. What are the heme precursors in order (1)delta-aminolevulinic acid, (2)porpho-
of synthesis? bilinogen, (3)uroporphyrinogen, (4)copro-
porphyrinogen, (5)protoporphyrin, (6)heme
24. What type of hemoglobin is seen primar- Hgb F
ily in newborns?
25. What type of hemoglobin is seen primar- Hgb A2
ily in adults?
26. What type of hemoglobin is rarely seen Hgb A
in adults as well as newborns?
27. What hemoglobin types are seen in em- gower I, gower II, portland
bryos but not in adults or newborns?
28. All non-embryonic hemoglobin types are alpha
comprised of what type of globin chain?
29. Hemoglobin A2 is composed of what alpha, beta
types of globin chains?
30. Hemoglobin A is composed of what alpha, delta
types of globin chains?
31. Hemoglobin F is composed of what types alpha, gamma
of globin chains?
