NSG 6005 Pharm Weeks 1-3 Quiz (from operation FNP Class 11) QUESTIONS WITH ANSWERS

NSG 6005 Pharm Weeks 1-3 Quiz (from
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operation FNP Class 11) QUESTIONS WITH |\ |\ |\ |\ |\ |\




ANSWERS

Genetic polymorphisms account for differences in metabolism,
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including:


1. Poor metabolizers, who lack a working enzyme
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2. Intermediate metabolizers, who have one working, wild-type
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allele and one mutant allele
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3. Extensive metabolizers, with two normally functioning alleles
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4. All of the above - CORRECT ANSWERS ✔✔4. All of the above
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Up to 21% of Asians are ultra-rapid 2D6 metabolizers, leading to:
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1. A need to monitor drugs metabolized by 2D6 for toxicity
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2. Increased dosages needed of drugs metabolized by 2D6, such
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as the selective serotonin reuptake inhibitors
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3. Decreased conversion of codeine to morphine by CYP 2D6
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,4. The need for lowered dosages of drugs, such as beta blockers -
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CORRECT ANSWERS ✔✔2. Increased dosages needed of drugs
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metabolized by 2D6, such as the selective serotonin reuptake
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inhibitors


Rifampin is a nonspecific CYP450 inducer that may:
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1. Lead to toxic levels of rifampin and must be monitored closely
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2. Cause toxic levels of drugs, such as oral contraceptives, when
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coadministered


3. Induce the metabolism of drugs, such as oral contraceptives,
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leading to therapeutic failure
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4. Cause nonspecific changes in drug metabolism - CORRECT
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ANSWERS ✔✔3. Induce the metabolism of drugs, such as oral
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contraceptives, leading to therapeutic failure |\ |\ |\ |\




Inhibition of P-glycoprotein by a drug such as quinidine may lead
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to:


1. Decreased therapeutic levels of quinidine
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2. Increased therapeutic levels of quinidine
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,3. Decreased levels of a coadministered drug, such as digoxin,
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that requires P-
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glycoprotein for absorption and elimination |\ |\ |\ |\




4. Increased levels of a coadministered drug, such as digoxin,
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that requires P-
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glycoprotein for absorption and elimination - CORRECT ANSWERS
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✔✔4. Increased levels of a coadministered drug, such as digoxin,
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that requires P-
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glycoprotein for absorption and elimination |\ |\ |\ |\




Warfarin resistance may be seen in patients with VCORC1
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mutation, leading to: |\ |\




1. Toxic levels of warfarin building up
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2. Decreased response to warfarin
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3. Increased risk for significant drug interactions with warfarin
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4. Less risk of drug interactions with warfarin - CORRECT
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ANSWERS ✔✔2. Decreased response to warfarin
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Genetic testing for VCORC1 mutation to assess potential warfarin
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resistance is required prior to prescribing warfarin.
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, 1. True
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2. False - CORRECT ANSWERS ✔✔2. False
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Pharmacogenetic testing is required by the U.S. Food and Drug |\ |\ |\ |\ |\ |\ |\ |\ |\ |\


Administration prior to prescribing: |\ |\ |\




1. Erythromycin
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2. Digoxin
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3. Cetuximab
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4. Rifampin - CORRECT ANSWERS ✔✔3. Cetuximab
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Carbamazepine has a Black Box Warning recommending testing|\ |\ |\ |\ |\ |\ |\ |\


for the HLA-
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B*1502 allele in patients with Asian ancestry prior to starting
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therapy due to: |\ |\




1. Decreased effectiveness of carbamazepine in treating seizures
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in Asian patients with the HLA-B*1502 allele
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2. Increased risk for drug interactions in Asian patients with the
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HLA-B*1502 allele |\