Questions and Answers | 100% Pass
What is the moa for diuretics? - 🧠 ANSWER ✔✔Affects Maintenance of ecf
volume and composition
What is the Path that urine takes through the nephron - 🧠 ANSWER
✔✔Glomerulus▶️Prox convol tube▶️Loop of Henle: Descrnding
limb▶️Ascending limb▶️DCT▶️Collecting duct
What is the site of action for osmotic diuretics like
Mannitol? - 🧠 ANSWER ✔✔Proximal convoluted tubule
What is the Site of action for Thiazide diuretics like
HCTZ? - 🧠 ANSWER ✔✔Early distal convoluted tubule
What is the (site of action for Potassium sparing diuretics like
, Spironolactone? - 🧠 ANSWER ✔✔Late distal convoluted tubule and
collecting duct (distal nephron)
What is the sote of action for Loop diuretics like
Furosemide? - 🧠 ANSWER ✔✔Loop of Henle
Loop diuretics cause drug toxicity due to increased Na+ excretion. - 🧠
ANSWER ✔✔Lithium excretion is decreased with hyponatremia and
causes lithium toxicity.
Nephron order of diuretic action - 🧠 ANSWER ✔✔Osmotics▶️Loops
▶️Thiazides▶️K+ sparing
PCT (proximal convoluted tubule) - 🧠 ANSWER ✔✔High resorptive
capacity. About 65% of filtered Na+ and Cl resorbed here. Urine is isotonic
Freely permeable to water - 🧠 ANSWER ✔✔Descending limb loop of Henle
Na/K exchange: Na+ reabsorbed, K+ excreted stimulated by - 🧠 ANSWER
✔✔Distal nephron: late DCT/CD
Causes transient deafness - 🧠 ANSWER ✔✔Furosemide
Only diuretic class that is ototoxic - 🧠 ANSWER ✔✔Loop diuretics (pg451)