Cctn Practice Guide
Questions And Correct
Answers Graded A+ 2025-
2026
Cholestasis - ANS-a condition where the bile cannot flow from the liver to the
duodenum of the small intestines.
Intrahepatic bile duct - ANS-passes through and drain bile from the liver.
Diseases that affect the Intrahepatic bile duct are: - ANS-biliary atresia
Primary biliary cirrhosis
Iatrogenic drug induced diseases
Familial cholestasis
Cystic fibrosis
Biliary atresia - ANS-common bile duct between the liver and small intestines is
blocked.
Primary biliary cirrhosis - ANS-disease that destroys the bile ducts in the liver.
Iatrogenic drug induced diseases - ANS-chlorpromazine
tolbutamide
Familial cholestasis - ANS-Byler's syndrome
Arteriohepatic dysplasia
Cystic fibrosis - ANS-sticky buildup of mucus in the intestines can lead to
inspissated (thickened, dried) bile syndrome and cirrhosis.
, IDDM (Insulin Dependent Diabetes Mellitus)- Brittle Type 1 Diabetes
(no signs of advanced diabetic nephropathy) - ANS-the most common disease
that requires a pancreas transplant.
alcoholism with liver changes - ANS-most common disease that require a liver
transplant
cholestasis - ANS-most common disease that require a liver transplant
chronic hepatitis - ANS-most common disease that require a liver transplant
genetic diseases (Crigler-Najjar syndrome, hereditary oxalises, familial
hypercholesterolemia). - ANS-most common disease that require a liver
transplant
hepatocellular carcinoma (HCC)- <5 cm accompanied by cirrhosis - ANS-most
common dx. that req. a liver transplant.
metabolic disease - ANS-most common dx. that req. a liver transplant.
Coagulopathy of liver disease - ANS-Cirrhosis
Impaired hepatic function
*Decreased synthesis of clotting factors II, V, VII, IX and fibrinogen*
Factor VIII levels occasionally ↑
PT prolonged, aPTT prolonged in longstanding disease
*Usually does not require treatment unless bleeding complications occur*
FFP if active bleeding with prolonged aPTT and PTT
Cryoprecipitate if fibrinogen < 80 mg/dL
organ transplant
Hepatic encephalopathy - ANS-impaired ammonia metabolism causes cerebral
edema. s/s: change in LOC, memory loss, asterixis (flapping tremor) impaired
handwriting, hyperventilation w/ resp alkalosis. Rx: lactulose, low protein, safety,
rest
Questions And Correct
Answers Graded A+ 2025-
2026
Cholestasis - ANS-a condition where the bile cannot flow from the liver to the
duodenum of the small intestines.
Intrahepatic bile duct - ANS-passes through and drain bile from the liver.
Diseases that affect the Intrahepatic bile duct are: - ANS-biliary atresia
Primary biliary cirrhosis
Iatrogenic drug induced diseases
Familial cholestasis
Cystic fibrosis
Biliary atresia - ANS-common bile duct between the liver and small intestines is
blocked.
Primary biliary cirrhosis - ANS-disease that destroys the bile ducts in the liver.
Iatrogenic drug induced diseases - ANS-chlorpromazine
tolbutamide
Familial cholestasis - ANS-Byler's syndrome
Arteriohepatic dysplasia
Cystic fibrosis - ANS-sticky buildup of mucus in the intestines can lead to
inspissated (thickened, dried) bile syndrome and cirrhosis.
, IDDM (Insulin Dependent Diabetes Mellitus)- Brittle Type 1 Diabetes
(no signs of advanced diabetic nephropathy) - ANS-the most common disease
that requires a pancreas transplant.
alcoholism with liver changes - ANS-most common disease that require a liver
transplant
cholestasis - ANS-most common disease that require a liver transplant
chronic hepatitis - ANS-most common disease that require a liver transplant
genetic diseases (Crigler-Najjar syndrome, hereditary oxalises, familial
hypercholesterolemia). - ANS-most common disease that require a liver
transplant
hepatocellular carcinoma (HCC)- <5 cm accompanied by cirrhosis - ANS-most
common dx. that req. a liver transplant.
metabolic disease - ANS-most common dx. that req. a liver transplant.
Coagulopathy of liver disease - ANS-Cirrhosis
Impaired hepatic function
*Decreased synthesis of clotting factors II, V, VII, IX and fibrinogen*
Factor VIII levels occasionally ↑
PT prolonged, aPTT prolonged in longstanding disease
*Usually does not require treatment unless bleeding complications occur*
FFP if active bleeding with prolonged aPTT and PTT
Cryoprecipitate if fibrinogen < 80 mg/dL
organ transplant
Hepatic encephalopathy - ANS-impaired ammonia metabolism causes cerebral
edema. s/s: change in LOC, memory loss, asterixis (flapping tremor) impaired
handwriting, hyperventilation w/ resp alkalosis. Rx: lactulose, low protein, safety,
rest
