ABSITE – BREAST QUESTIONS WITH
CORRECT ANSWERS 2025
Which of the following is correct in relation to BRCA1/2 mutations and breast cancer? -
CORRECT ANSWER -
The lifetime risk (by age 70) of developing breast cancer for BRCA1 mutation carriers can be as high as
80%.
(Correct. BRCA mutations carry a 50% to 80% lifetime risk of female breast cancer, a 6% lifetime risk o
f male breast cancer (BRCA2), and a 15% to 25% lifetime risk of ovarian cancer. BRCA1 mutation carrie
rs are more likely to present with breast cancer at a lower age than BRCA2 mutation carriers (peak inc
idence at 45-49 years and 65-
69 years, respectively). It is important to understand these statistics when considering either genetic t
esting or prevention strategies in a known BRCA mutation carrier.)
Which of the following treatments has been shown to provide relief of symptoms in more than 50% of
patients with cyclical breast pain? - CORRECT ANSWER -Evening primrose oil
The most common histologic type of invasive breast cancer is which of the following? -
CORRECT ANSWER -Ductal adenocarcinoma.
Hormone regulation of mammary epithelial development includes: - CORRECT ANSWER -
Initiation of ductal development by estrogen.
Which benign breast disease is associated with an increased risk of malignancy? - CORRECT ANSWER -
Atypical ductal hyperplasia
Which of the following statements regarding steroid hormones and breast cancer is correct?
- The kidney is the principle site of steroid metabolism.
- The rate-
limiting step of steroid hormone biosynthesis involves the conversion of pregnenolone to progesterone
.
-
In postmenopausal women, androgens are produced in the adrenal gland, and adipose tissue is the p
rincipal site for aromatization.
- Circulating steroid hormones are primarily lipid-bound and are thus considered "bioavailable." -
CORRECT ANSWER -
, In Upostmenopausal Uwomen, Uandrogens Uare Uproduced Uin Uthe Uadrenal Ugland, Uand Uadipose Utissue Uis
Uthe Upri Uncipal Usite Ufor Uaromatization.
(In Upostmenopausal Uwomen, Uandrogens Uare Uproduced Uin Uthe Uadrenal Ugland, Uand Uadipose Utissue Uis
Uthe Up Urincipal Usite Ufor Uaromatization. UNormal Uadipose Utissue Uuses Upromoter UI.4 Uof Uthe UCYP19
Ugene Uto Ustimulate Uaromatase U production; U however, U breast Utumors U and Utheir U surrounding
Uadipose U tissue U activate Upromoto U r UII Uof Uthe UCYP19 Ugene, Uand Uthe Uresult Uis Ua Ugreater Uexpression
Uof Uaromatase. UAIs Ucan Ureduce Uestrogen Upr Uoduction Uby Umore Uthan U90% Uand Uare Uclassified
Uaccording Uto Uthe Uspecificity, Upotency, Uand Ureversibility Uwi U th Uwhich Uthey Uinhibit Uthe Uaromatase
Uenzyme.)
Which Uof Uthe Ufollowing Uhistologic Ubreast Uchanges Uis Umost Uassociated Uwith Uan Uincreased Urisk Uof
Ubreast Uca Uncer?
- Epithelial U hyperplasia U with U atypia.
- Macro- U and U microcysts.
- Apocrine U metaplasia.
- Fibroadenoma.
- Duct U ectasia. U - U CORRECT U ANSWER U -Epithelial U hyperplasia U with U atypia.
Paget U disease U of U the U breast U - U CORRECT U ANSWER U -
Paget Udisease Uis Unearly Ualways Udetectable Uon Uclinical Uexamination Uas Ua Ucrusting Uerosion Uof Uthe
Unipple. UIt Umay Ube Uless Usubtle Upresenting Uwith Uthickening Uredness Uor Uroughness Uof Uthe Unipple,
Uoften Uassociated Uwit U h Uitching Uand Uburning. UIt Uis Uoften Uassociated Uwith Usubareolar Uintraductal
Ucancer. USurvival Uis Udependent Uu Upon Uthe Ustage Uof Uthe Uaccompanying Ubreast Ucancer.
A U42-year-old, Uotherwise Uhealthy U woman Uhas U a U new, U1-
cm Uin Udiameter Udensity Udeep Uin Uthe Ucentral Uretroareolar Uregion Uof Uher Uright Ubreast Uon
Umammography. US Uhe Uhas Uno Upalpable Uabnormality Uon Uphysical Uexamination. UNo Ulesion Uis
Udetected Uon Uultrasonography. UTh U e Ubest Udiagnostic Uoption Uis U- UCORRECT UANSWER U-stereotactic
Ucore Uneedle Ubiopsy Uof Uthe Ubreast
A U 32-
year Uold Umale Upresents Uto Uclinic Udue Uto Uenlarging Uleft Ubreast. UHe Ustates Uthat Uhe Uhas Unoticed Uthis
U"swellin U g" Ufor Uthe Upast Uyear Ubut Uhas Uonly Usought Umedical Ucare Unow Ubecause Uit Uhas Ubecoming
Unoticeably Ularger Ut Uhan Uhis Uright Ubreast. UHe Udenies Upain Uor Unipple Udischarge. UHe Udenies Ufamily
Uhistory Uof Ubreast Ucancer Uin Uei Uther Uwomen Uor Umen Uin Uhis Uimmediate Uor Udistant Ufamily Uand
Usteroid Uuse. UOn Uexamination, Uthe Upatient Uis Uvery Umuscular Uwith Ua Usmooth Uright Ubreast, Udevoid
Uof Umasses. UHis Uleft Ubreast Uis Unoted Uto Uhave Urubbery Umass Uextending Uconcentrically Ufrom Uthe
Unipple. UHis Utesticular Uexam Uis Unormal. UWhat Uis Uthe Uappropriate Umanagement Uof Uthis Upatient? U-
UCORRECT UANSWER U-Mammogram Uand Uultrasound
CORRECT ANSWERS 2025
Which of the following is correct in relation to BRCA1/2 mutations and breast cancer? -
CORRECT ANSWER -
The lifetime risk (by age 70) of developing breast cancer for BRCA1 mutation carriers can be as high as
80%.
(Correct. BRCA mutations carry a 50% to 80% lifetime risk of female breast cancer, a 6% lifetime risk o
f male breast cancer (BRCA2), and a 15% to 25% lifetime risk of ovarian cancer. BRCA1 mutation carrie
rs are more likely to present with breast cancer at a lower age than BRCA2 mutation carriers (peak inc
idence at 45-49 years and 65-
69 years, respectively). It is important to understand these statistics when considering either genetic t
esting or prevention strategies in a known BRCA mutation carrier.)
Which of the following treatments has been shown to provide relief of symptoms in more than 50% of
patients with cyclical breast pain? - CORRECT ANSWER -Evening primrose oil
The most common histologic type of invasive breast cancer is which of the following? -
CORRECT ANSWER -Ductal adenocarcinoma.
Hormone regulation of mammary epithelial development includes: - CORRECT ANSWER -
Initiation of ductal development by estrogen.
Which benign breast disease is associated with an increased risk of malignancy? - CORRECT ANSWER -
Atypical ductal hyperplasia
Which of the following statements regarding steroid hormones and breast cancer is correct?
- The kidney is the principle site of steroid metabolism.
- The rate-
limiting step of steroid hormone biosynthesis involves the conversion of pregnenolone to progesterone
.
-
In postmenopausal women, androgens are produced in the adrenal gland, and adipose tissue is the p
rincipal site for aromatization.
- Circulating steroid hormones are primarily lipid-bound and are thus considered "bioavailable." -
CORRECT ANSWER -
, In Upostmenopausal Uwomen, Uandrogens Uare Uproduced Uin Uthe Uadrenal Ugland, Uand Uadipose Utissue Uis
Uthe Upri Uncipal Usite Ufor Uaromatization.
(In Upostmenopausal Uwomen, Uandrogens Uare Uproduced Uin Uthe Uadrenal Ugland, Uand Uadipose Utissue Uis
Uthe Up Urincipal Usite Ufor Uaromatization. UNormal Uadipose Utissue Uuses Upromoter UI.4 Uof Uthe UCYP19
Ugene Uto Ustimulate Uaromatase U production; U however, U breast Utumors U and Utheir U surrounding
Uadipose U tissue U activate Upromoto U r UII Uof Uthe UCYP19 Ugene, Uand Uthe Uresult Uis Ua Ugreater Uexpression
Uof Uaromatase. UAIs Ucan Ureduce Uestrogen Upr Uoduction Uby Umore Uthan U90% Uand Uare Uclassified
Uaccording Uto Uthe Uspecificity, Upotency, Uand Ureversibility Uwi U th Uwhich Uthey Uinhibit Uthe Uaromatase
Uenzyme.)
Which Uof Uthe Ufollowing Uhistologic Ubreast Uchanges Uis Umost Uassociated Uwith Uan Uincreased Urisk Uof
Ubreast Uca Uncer?
- Epithelial U hyperplasia U with U atypia.
- Macro- U and U microcysts.
- Apocrine U metaplasia.
- Fibroadenoma.
- Duct U ectasia. U - U CORRECT U ANSWER U -Epithelial U hyperplasia U with U atypia.
Paget U disease U of U the U breast U - U CORRECT U ANSWER U -
Paget Udisease Uis Unearly Ualways Udetectable Uon Uclinical Uexamination Uas Ua Ucrusting Uerosion Uof Uthe
Unipple. UIt Umay Ube Uless Usubtle Upresenting Uwith Uthickening Uredness Uor Uroughness Uof Uthe Unipple,
Uoften Uassociated Uwit U h Uitching Uand Uburning. UIt Uis Uoften Uassociated Uwith Usubareolar Uintraductal
Ucancer. USurvival Uis Udependent Uu Upon Uthe Ustage Uof Uthe Uaccompanying Ubreast Ucancer.
A U42-year-old, Uotherwise Uhealthy U woman Uhas U a U new, U1-
cm Uin Udiameter Udensity Udeep Uin Uthe Ucentral Uretroareolar Uregion Uof Uher Uright Ubreast Uon
Umammography. US Uhe Uhas Uno Upalpable Uabnormality Uon Uphysical Uexamination. UNo Ulesion Uis
Udetected Uon Uultrasonography. UTh U e Ubest Udiagnostic Uoption Uis U- UCORRECT UANSWER U-stereotactic
Ucore Uneedle Ubiopsy Uof Uthe Ubreast
A U 32-
year Uold Umale Upresents Uto Uclinic Udue Uto Uenlarging Uleft Ubreast. UHe Ustates Uthat Uhe Uhas Unoticed Uthis
U"swellin U g" Ufor Uthe Upast Uyear Ubut Uhas Uonly Usought Umedical Ucare Unow Ubecause Uit Uhas Ubecoming
Unoticeably Ularger Ut Uhan Uhis Uright Ubreast. UHe Udenies Upain Uor Unipple Udischarge. UHe Udenies Ufamily
Uhistory Uof Ubreast Ucancer Uin Uei Uther Uwomen Uor Umen Uin Uhis Uimmediate Uor Udistant Ufamily Uand
Usteroid Uuse. UOn Uexamination, Uthe Upatient Uis Uvery Umuscular Uwith Ua Usmooth Uright Ubreast, Udevoid
Uof Umasses. UHis Uleft Ubreast Uis Unoted Uto Uhave Urubbery Umass Uextending Uconcentrically Ufrom Uthe
Unipple. UHis Utesticular Uexam Uis Unormal. UWhat Uis Uthe Uappropriate Umanagement Uof Uthis Upatient? U-
UCORRECT UANSWER U-Mammogram Uand Uultrasound
