https://www.stuvia.com/
,https://www.stuvia.com/
Chapter 1 RBCsand Platelet Preservation: Historical Perspectives and Current Trends
ss ss ss ss ss xx ss ss ss
Multiple Choice ss
Identify the choice that best completes the statement or answers the question.
ss ss ss ss ss ss ss ss ss ss ss
1. Which metabolic pathway is responsible for generating 90% of theATPfor the RBC?
xx ss s ss ss ss ss ss ss s s ss ss
a. Pentose phosphate shunt c. Glycolysis ss ss
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss ss
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed.
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
The unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
accurate? ss
a. The unit of blood should be discarded immediately. ss ss ss ss ss ss ss
b. The unit of blood can be returned to inventory. ss ss ss ss ss ss ss ss
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
d. The unit of blood must be transfused with 24 hours. ss ss ss ss ss ss ss ss ss
3. What is the average diameter of a platelet?
ss ss ss ss ss ss ss
a. 5 to 10 µm ss ss ss c. 1 to 2 µm ss ss ss
b. 2 to 4 µm ss ss ss d. 4 to 6 µm ss ss ss
4. In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to the
ss ss ss ss ss ss ss ss ss ss xx ss ss
tissues when PO2
ss averages 40 mm Hg? ss ss s s ss ss ss
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
ss ss ss ss ss ss ss xx ss
a. Storage temperature c. Platelet count ss ss
b. Initial pH d. All of the above ss ss ss ss
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
result of loss of RBC membrane?
ss ss ss ss ss ss
a. Spherocytes c. Burr cells xx
b. Target cells d. Schistocytes ss
7. What does the term autologous transfusion refer to?
ss ss ss ss xx ss ss
a. Aparent donating blood for his or her child
s ss ss xx ss ss ss xx
b. An individual donating blood for a friend ss ss ss ss ss xx
c. An individual donating blood for a relative ss xx ss xx ss ss
d. An individual donating blood for his or her own transfusion
ss xx ss ss xx ss ss ss ss
8. What is the primary function of hemoglobin?
xx ss ss ss xx ss
a. Iron metabolism c. Oxygen transport
ss ss
b. Porphyrin synthesis d. Signal transduction ss ss
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss s s
a. Cellular metabolism. c. Site of theABO antigen attachment.ss s ss s ss ss
b. RBC membrane. d. Hemoglobin structure.
ss ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
s s 10. What is the correct biochemical composition of the RBC membrane?
ss ss ss ss ss ss ss ss ss
a. 52% protein, 40% lipid, 8% carbohydrate ss ss ss ss ss
b. 40% protein, 8% lipid, 52% carbohydrate ss ss ss ss ss
c. 8% protein, 52% lipid, 40% carbohydrate
ss ss ss ss ss
d. 8% lipid, 40% carbohydrate, 52% protein
ss ss ss ss ss
s s 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
except:
a. Decreased pH. c. Increased ATP level. ss xx ss
b. Loss of red blood cell function. d. Decreased glucose consumption.
ss ss ss ss ss ss ss
s s 12. Which red blood cell preservative has a storage time of 35 days?
ss ss ss ss ss ss ss ss ss ss ss
a. ACD c. AS-1
b. CPDA-1 d. CPD
s s 13. The RBC membrane is relatively permeable to all of the following except:
ss ss ss ss ss ss ss ss ss ss ss
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water.
s s 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
from the bone marrow?
ss ss ss ss
a. 30% c. 10%
b. 50% d. 25%
s s 15. What is the major biochemical consideration in platelet storage?
ss ss ss ss ss ss xx ss
a. Glucose metabolism c. Production of carbon dioxide
ss ss ss ss
b. Oxygen supply d. Regulation of pH ss s s x s s x s s ss ss
s s 16. What would the hemoglobin-oxygen dissociation curve depict in a patient exhibiting clinical
ss ss ss ss ss ss ss ss xx ss ss ss
signs of alkalosis?
ss ss ss
a. Normal c. Shift to the right ss xx ss
b. Shift to the left d. None of the above
ss ss ss ss ss ss
s s 17. Name the main lipid components of a red blood cell membrane.
ss ss ss ss ss ss ss xx ss ss
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A ss
s s 18. The ABO blood groups were discovered in 1901 by whom?
ss ss ss ss ss ss ss ss ss
a. Charles Drew c. Loutit and Mollison xx ss ss
b. Karl Landsteiner d. Edward Lindeman
xx ss
s s 19. A standing order of platelets was shipped to your facility by your supplier. It was
s s s s s s s s s s xx s s ss s s s s s s s s s s s s s s
inadvertently left in the corner of the department until discovered 36 hours later. What would the
s s s s s s ss ss ss ss ss ss ss ss ss ss ss ss ss
appropriate action be for the blood banker?
ss ss ss ss ss ss ss
a. If the temperature in the box was 22 +/- 2°C and the platelet swirl seemed OK, it would
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
be OK to accept the unit into inventory.
ss ss ss ss ss ss ss ss
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
ss ss ss ss ss ss ss ss ss ss ss ss
discarded because the pH has probably dropped too low and platelet activation has
s s ss ss ss ss ss ss ss ss ss ss ss ss
been compromised.
ss ss
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. ss ss ss ss
d. If the platelets appeared OK and passed the platelet swirl test after being placed on
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
the agitator, they could be accepted into the inventory.
ss ss ss ss ss ss ss ss ss
s s 20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
ss ss ss ss ss ss ss ss ss
a. Glycolysis c. Pentose phosphate shunt ss ss
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss ss
s s 21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
except:
a. Increased 2,3-DPG. ss
b. 50% O2 saturation to tissues.
ss s s ss ss
c. Decreased 2,3-DPG. xx
d. Decreased hemoglobin affinity for O2. xx ss ss ss
s s 22. What is the normal platelet count range per cubic millimeter?
ss ss ss ss ss ss ss ss ss
a. 100 to 350 ss c. 50,000 to 200,000
ss ss ss
b. 150,000 to 350,000 d. 350,000 to 500,000
ss ss ss ss
s s 23. What cryoprotective agent is added to red blood cells upon freezing?
ss ss ss ss ss ss ss ss ss ss
a. Dextrose c. Glycerol
b. Adsol d. All of the above ss ss ss
s s 24. If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
a. 1°C to 6°C ss ssc. 35°C to 37°C xx s s
b. 20°C to 24°C ss d. 1°C to 10°C
ss xx xx
s s 25. What role do platelets play in hemostasis?
ss ss ss ss ss ss
a. Maintenance of vascular integrity ss ss ss
b. Initial arrest of bleeding by platelet plug formation
ss ss ss ss ss ss xx
c. Stabilization of the hemostatic plug ss ss ss ss
d. All of the above
ss ss ss
s s 26. Which of the following best describes "integral" membrane proteins?
ss ss ss ss ss ss ss ss
a. Reside at the cytoplasmic surface of membrane
ss ss ss xx ss ss
b. Span the entire membrane surface
ss ss ss x ss
c. Form the red blood cell cytoskeleton
ss ss ss ss xx
d. None of the above ss ss ss
s s 27. How is stroma-free hemoglobin solution prepared?
ss ss ss xx ss
a. Outdated red blood cells are concentrated, and stroma is removed.
xx ss ss ss ss ss ss ss ss
b. Outdated red blood cells are diluted with saline, and stroma is removed.
ss ss ss xx ss ss ss ss ss ss ss
c. Outdated red blood cells are lysed, and stroma is removed.
xx ss ss xx ss ss ss ss ss
d. None of the above ss ss ss
s s 28. What is the normal life span of an RBC?
ss ss ss xx ss ss ss ss
a. 100 days ss c. 120 hours ss
b. 120 days ss d. 2 days ss
s s 29. Regarding loss of RBC membrane deformability, all of the following are true except:
ss ss ss ss ss ss ss ss ss ss ss ss
a. Increase inATPlevel. ss s s
b. Decrease inATP level. ss s ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
Chapter 1 RBCsand Platelet Preservation: Historical Perspectives and Current Trends
ss ss ss ss ss xx ss ss ss
Multiple Choice ss
Identify the choice that best completes the statement or answers the question.
ss ss ss ss ss ss ss ss ss ss ss
1. Which metabolic pathway is responsible for generating 90% of theATPfor the RBC?
xx ss s ss ss ss ss ss ss s s ss ss
a. Pentose phosphate shunt c. Glycolysis ss ss
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss ss
2. A unit of blood was returned to the blood bank before it was spiked. Apparently the patient’s IV failed.
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
The unit of blood was outside the blood bank for 35 minutes. Which of the statements below is most
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
accurate? ss
a. The unit of blood should be discarded immediately. ss ss ss ss ss ss ss
b. The unit of blood can be returned to inventory. ss ss ss ss ss ss ss ss
c. The unit of blood must be transfused within 4 hours or be discarded at the end of that time.
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
d. The unit of blood must be transfused with 24 hours. ss ss ss ss ss ss ss ss ss
3. What is the average diameter of a platelet?
ss ss ss ss ss ss ss
a. 5 to 10 µm ss ss ss c. 1 to 2 µm ss ss ss
b. 2 to 4 µm ss ss ss d. 4 to 6 µm ss ss ss
4. In the normal hemoglobin-oxygen dissociation curve, what percentage of oxygen is released to the
ss ss ss ss ss ss ss ss ss ss xx ss ss
tissues when PO2
ss averages 40 mm Hg? ss ss s s ss ss ss
a. 75% c. 100%
b. 25% d. 50%
5. What factors are known to influence platelet metabolism and function?
ss ss ss ss ss ss ss xx ss
a. Storage temperature c. Platelet count ss ss
b. Initial pH d. All of the above ss ss ss ss
6. Which of the following red blood cell morphologies may be present on the peripheral blood smear as a
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
result of loss of RBC membrane?
ss ss ss ss ss ss
a. Spherocytes c. Burr cells xx
b. Target cells d. Schistocytes ss
7. What does the term autologous transfusion refer to?
ss ss ss ss xx ss ss
a. Aparent donating blood for his or her child
s ss ss xx ss ss ss xx
b. An individual donating blood for a friend ss ss ss ss ss xx
c. An individual donating blood for a relative ss xx ss xx ss ss
d. An individual donating blood for his or her own transfusion
ss xx ss ss xx ss ss ss ss
8. What is the primary function of hemoglobin?
xx ss ss ss xx ss
a. Iron metabolism c. Oxygen transport
ss ss
b. Porphyrin synthesis d. Signal transduction ss ss
9. All of the following areas of red blood cell biology are crucial for normal erythrocyte survival except:
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss s s
a. Cellular metabolism. c. Site of theABO antigen attachment.ss s ss s ss ss
b. RBC membrane. d. Hemoglobin structure.
ss ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
s s 10. What is the correct biochemical composition of the RBC membrane?
ss ss ss ss ss ss ss ss ss
a. 52% protein, 40% lipid, 8% carbohydrate ss ss ss ss ss
b. 40% protein, 8% lipid, 52% carbohydrate ss ss ss ss ss
c. 8% protein, 52% lipid, 40% carbohydrate
ss ss ss ss ss
d. 8% lipid, 40% carbohydrate, 52% protein
ss ss ss ss ss
s s 11. All of the following biochemical changes are associated with loss of red blood cell viability upon storage
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
except:
a. Decreased pH. c. Increased ATP level. ss xx ss
b. Loss of red blood cell function. d. Decreased glucose consumption.
ss ss ss ss ss ss ss
s s 12. Which red blood cell preservative has a storage time of 35 days?
ss ss ss ss ss ss ss ss ss ss ss
a. ACD c. AS-1
b. CPDA-1 d. CPD
s s 13. The RBC membrane is relatively permeable to all of the following except:
ss ss ss ss ss ss ss ss ss ss ss
a. Chloride. c. Bicarbonate.
b. Sodium. d. Water.
s s 14. What percentage of platelets is sequestered in the spleen as functional reserve after being released
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
from the bone marrow?
ss ss ss ss
a. 30% c. 10%
b. 50% d. 25%
s s 15. What is the major biochemical consideration in platelet storage?
ss ss ss ss ss ss xx ss
a. Glucose metabolism c. Production of carbon dioxide
ss ss ss ss
b. Oxygen supply d. Regulation of pH ss s s x s s x s s ss ss
s s 16. What would the hemoglobin-oxygen dissociation curve depict in a patient exhibiting clinical
ss ss ss ss ss ss ss ss xx ss ss ss
signs of alkalosis?
ss ss ss
a. Normal c. Shift to the right ss xx ss
b. Shift to the left d. None of the above
ss ss ss ss ss ss
s s 17. Name the main lipid components of a red blood cell membrane.
ss ss ss ss ss ss ss xx ss ss
a. Phospholipid c. Glycolipid
b. Sphingomyelin d. Glycophorin A ss
s s 18. The ABO blood groups were discovered in 1901 by whom?
ss ss ss ss ss ss ss ss ss
a. Charles Drew c. Loutit and Mollison xx ss ss
b. Karl Landsteiner d. Edward Lindeman
xx ss
s s 19. A standing order of platelets was shipped to your facility by your supplier. It was
s s s s s s s s s s xx s s ss s s s s s s s s s s s s s s
inadvertently left in the corner of the department until discovered 36 hours later. What would the
s s s s s s ss ss ss ss ss ss ss ss ss ss ss ss ss
appropriate action be for the blood banker?
ss ss ss ss ss ss ss
a. If the temperature in the box was 22 +/- 2°C and the platelet swirl seemed OK, it would
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
be OK to accept the unit into inventory.
ss ss ss ss ss ss ss ss
b. The platelets have fallen outside the supplier’s quality assurance. The unit should be
ss ss ss ss ss ss ss ss ss ss ss ss
discarded because the pH has probably dropped too low and platelet activation has
s s ss ss ss ss ss ss ss ss ss ss ss ss
been compromised.
ss ss
c. If the temperature was 1°C to 6°C and the platelet swirl seemed OK, it would be OK to
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
,https://www.stuvia.com/
accept the unit into inventory. ss ss ss ss
d. If the platelets appeared OK and passed the platelet swirl test after being placed on
ss ss ss ss ss ss ss ss ss ss ss ss ss ss
the agitator, they could be accepted into the inventory.
ss ss ss ss ss ss ss ss ss
s s 20. Which metabolic pathway permits the accumulation of 2,3 diphosphoglycerate (2,3-DPG)?
ss ss ss ss ss ss ss ss ss
a. Glycolysis c. Pentose phosphate shunt ss ss
b. Luebering-Rapoport shunt d. Methemoglobin reductase ss ss
s s 21. All of the following are consistent with a "shift to the right" of the hemoglobin-oxygen dissociation curve
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
except:
a. Increased 2,3-DPG. ss
b. 50% O2 saturation to tissues.
ss s s ss ss
c. Decreased 2,3-DPG. xx
d. Decreased hemoglobin affinity for O2. xx ss ss ss
s s 22. What is the normal platelet count range per cubic millimeter?
ss ss ss ss ss ss ss ss ss
a. 100 to 350 ss c. 50,000 to 200,000
ss ss ss
b. 150,000 to 350,000 d. 350,000 to 500,000
ss ss ss ss
s s 23. What cryoprotective agent is added to red blood cells upon freezing?
ss ss ss ss ss ss ss ss ss ss
a. Dextrose c. Glycerol
b. Adsol d. All of the above ss ss ss
s s 24. If platelets are to be stored for 5 days on a rotator, what is the optimal storage temperature?
ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss ss
a. 1°C to 6°C ss ssc. 35°C to 37°C xx s s
b. 20°C to 24°C ss d. 1°C to 10°C
ss xx xx
s s 25. What role do platelets play in hemostasis?
ss ss ss ss ss ss
a. Maintenance of vascular integrity ss ss ss
b. Initial arrest of bleeding by platelet plug formation
ss ss ss ss ss ss xx
c. Stabilization of the hemostatic plug ss ss ss ss
d. All of the above
ss ss ss
s s 26. Which of the following best describes "integral" membrane proteins?
ss ss ss ss ss ss ss ss
a. Reside at the cytoplasmic surface of membrane
ss ss ss xx ss ss
b. Span the entire membrane surface
ss ss ss x ss
c. Form the red blood cell cytoskeleton
ss ss ss ss xx
d. None of the above ss ss ss
s s 27. How is stroma-free hemoglobin solution prepared?
ss ss ss xx ss
a. Outdated red blood cells are concentrated, and stroma is removed.
xx ss ss ss ss ss ss ss ss
b. Outdated red blood cells are diluted with saline, and stroma is removed.
ss ss ss xx ss ss ss ss ss ss ss
c. Outdated red blood cells are lysed, and stroma is removed.
xx ss ss xx ss ss ss ss ss
d. None of the above ss ss ss
s s 28. What is the normal life span of an RBC?
ss ss ss xx ss ss ss ss
a. 100 days ss c. 120 hours ss
b. 120 days ss d. 2 days ss
s s 29. Regarding loss of RBC membrane deformability, all of the following are true except:
ss ss ss ss ss ss ss ss ss ss ss ss
a. Increase inATPlevel. ss s s
b. Decrease inATP level. ss s ss
This study source was downloaded by 100000826342158 from CourseHero.com on 09-15-2021 17:54:15
ss ss ss ss ss ss ss ss ss ss ss
GMT -
https://www.coursehero.com/file/25537437/ch01rtf/
