QUESTIONS AND ANSWERS
How do benzodiazepine help with anxiety? - ANS Benzodiazepine target GABA
neurotransmission via the PAM (positive allosteric modulation
Allodynia - ANS Pain due to a stimulus that does not normally provoke pain
Hyperalgesia - ANS Increased pain from a stimulus that normally provokes pain
Nocioceptive pain - ANS Pain that arises from actual or threatened damage to non-neural
tissue and is due to the aciviation of .....
Neuropathic pain - ANS Pain created by a lesion or disease of the somatosensory nervous
system
Central Sensitization - ANS Increased responsiveness of nocioceptive neurons in the CNS to
their normal or subthreshold afferent input.
Nocioceptor - ANS A primary afferent (sensory) neuron that is only activated by a noxious
stimulus
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, Nocioception - ANS The process by which a nocioceptor detects a noxious stimulus and
generates a signal (action potentials) that is propagated towards higher centers in the
nocioceptive pathway
Dorsal Root Ganglion (DRG) - ANS Contains the cell bodies of primary afferent neurons,
proteins, including transmitters, receptors, and structural proteins, are synthesized here and
transported to peripheral and central terminals.
Interneurons - ANS Neuron in the dorsal horn that receives input from PANS and/ or
interneurons, and projects up the spinal cord to higher processing centers
Spinothalamic tract - ANS tract of neurons that project from the spinal cord to the thalamus
Spinobulbar tracts - ANS Several different tracts of neurons that project from the spinal cord
to brainstem nuclei
Somatosensory cortex - ANS Region of the cerebral cortex that receives input mainly from
cutaneous sensory nerves; the cortex is topographically arranged, with adjacent areas receiving
input from adjacent body areas; stimulation of the somatosensory cortex creates sensations
from the body part that projects to it.
A-Beta fibers - ANS detect small movements, light touch
A-Delta fibers - ANS sense noxious mechanical stimuli and subnoxious thermalstimuli
C-fibers - ANS bare nerve endings that are only activated by noxious mechanical, thermal, or
chemical stimuli
Describe Neuropathic Pain - ANS pain that arises from damage to, or dysfunction of, any part
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of the peripheral or central nervous system
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