For Understanding Pathophysiology, Canadian Fist
Edition By Mohamed Toufic El-Hussein
Graded A+
,Chapter 01: Genes And Genetic Diseases
Power-Kean Et Al: Huether And Mccance’s Understanding Pathophysiology, Fast Canadian Edition
Multiple Choice
1. A Nurse Recalls That The Basic Components Of Dna Are:
A. Pentose Sugars And Four Phosphate Bases.
B. A Phosphate Molecule, Deoxyribose, And Four Nitrogenous Bases.
C. Adenine, Guanine, And Purine.
D. Codons, Oxygen, And Cytosine.
Ans: B
The Three Basic Components Of Dna Are Deoxyribose; A Phosphate Molecule; And Four Types Of
Nitrogenous, Not Phosphate, Bases. Dna Does Not
Contain Condone.
Dif: Cognitive Level: Remember Ref: Definitions: Composition And Structure Of Dna Top: Physiological
Integrity
2. Which Of The Following Mutations Have The Most Significant Effect On Protein Synthesis?
A. Base Pair Substitutions
B. Silent Mutations
C. Intron Mutations
D. Frameshift Mutations
Ans: D
The Frameshift Mutation Involves The Insertion Or Deletion Of One Or More Base Pairs Of The Dna
Molecule. This Greatly Alters The Amino Acid
Sequence, Which Affects Protein Synthesis. The Base Pair Substitution Is A Type Of Mutation In Which
One Base Pair Replaces Another. Silent
Mutations Do Not Change Amino Acids Or Protein Synthesis. Intron Mutations Are Part Of Rna
Sequencing.
,Dif: Cognitive Level: Remember Ref: Mutation Top: Physiological Integrity
3. The Base Components Of Dna Are:
A. A, G, C, And U.
B. P, G, C, And T.
C. A, G, C, And T.
D. X, Xx, Xy, And Yy.
Ans: C
The Four Base Components Of Dna Are Cytosine, Thymine, Adenine, And Guanine, And They Are
Commonly Represented By Their First Letters (C, T,
A, And G). There Are No Genetic Components Identified As P Or U. The Letters X, Xx, Xy, And Yy Are
Components Of Human Chromosomes.
Dif: Cognitive Level: Remember Ref: Dna As The Genetic Code | Figure 2.2 Top: Physiological Integrity
4. A Dna Strand Has A Region With The Sequence Atcggat. Which Of The Following Would Be A
Complementary Strand?
A. Cgatacgt
B. Tagcctag
C. Tugcctug
D. Uagccuag
Ans: B
The Consistent Pairing Of Adenine With Thymine And Of Guanine With Cytosine Is Known As
Complementary Base Pairing; Thus, A Complements To
T, And C To G, And Vice Versa Throughout The Strand. A Complements To T; Thus, The First Letter Must
Be A T. U Does Not Represent A
Complement In The Sequence.
Dif: Cognitive Level: Understand Ref: Replication Of Dna | Figure 2.2 Top: Physiological Integrity
5. A Biologist Is Explaining How Rna Directs The Synthesis Of Protein. Which Process Is The Biologist
Describing?
A. Termination
, B. Transcription
C. Translocation
D. Translation
Ans: D
In Translation, Rna Directs The Synthesis Of A Polypeptide, Interacting With Transfer Rna (Trna), A
Cloverleaf-Shaped Strand Of About 80
Nucleotides. Termination Does Not Involve The Synthesis Of Protein. Transcription Is The Process By
Which Dna Specifies A Sequence Of Messenger
Rna (Mrna). Translocation Is The Interchange Of Genetic Material Between Nonhomologous
Chromosomes.
Dif: Cognitive Level: Understand Ref: Translation Top: Physiological Integrity
Neurofibromatosis
6. What Is The Result Of Homologous Chromosomes Failing To Separate During Meiosis?
A.
B.
C.
D.
Aneuploidy
Polyploidy
Conjoined Twins
Ans: B
Nondisjunction Is An Error In Which Homologous Chromosomes Or Sister Chromatids Fail To Separate
Normally During Meiosis Or Mitosis. The
Result Is Aneuploidy. Neurofibromatosis Is Not Due To Chromosome Failure During Meiosis. Polyploidy
Occurs When A Euploid Cell Has More Than
The Diploid Number Of Chromosomes. Conjoined Twins Are Not Due To Chromosome Failure During
Meiosis.
Dif:
Cognitive Level: Remember
Diploid
Ref: Aneuploidy