c Y c Y c Y c Y c Y c Y c Y
and Molecular Diagnostics 8th
c Y Y
c c Y
c Y Edition by Nader Rifai, PhD Chapters
c Y Y
c c Y c Y c Y
c Y 1 - 49
c Y Y
c
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TietzYFundamentals Yof YClinical YChemistry Yand YMolecularYDiagnostics Y8th Y Edition YTest
c c c c c c c c
c
c
Y Bank
c
Table Yof Ycontents: c c
I. YPrinciples YOfYLaboratory YMedicine
c c c c
Chapter Y1. YClinicalYChemistry, Y Molecular YDiagnostics, Yand YLaboratoryYMedicine
c c c c c c c c
Chapter Y2. YSelectionYand Y AnalyticalYEvaluation YofYMethods Y— YWithYStatisticalYTechniques
c c c c c c c c c c c
Chapter Y3. YClinicalYEvaluationYofYMethods
c c c c c
Chapter Y4. YEvidence-Based YLaboratoryYMedicine
c c c c
Chapter Y5. YEstablishment Y and YUse YofYReference YValues
c c c c c c c
Chapter Y6. YSpecimenYCollection, Y Processing, Yand Y Other YPreanalyticalYVariables
c c c c c c c c
Chapter Y7. YQualityYManagement c c c
II. YAnalytical YTechniquesYAnd YInstrumentation
c c c c
Chapter Y8. YPrinciples YofYBasic YTechniques Yand YLaboratoryYSafety
c c c c c c c c
Chapter Y9. YOpticalYTechniques c c c
Chapter Y10. YElectrochemistryYand YChemicalYSensors
c c c c c
Chapter Y11. YElectrophoresis c c
Chapter Y12. YChromatography c c
Chapter Y13. YMass YSpectrometry c c c
Chapter Y14.YEnzyme Yand YRate YAnalyses
c c c c c
Chapter Y15. YImmunochemicalYTechniques
c c c
Chapter Y16 YAutomation c c
Chapter Y17.YPoint-of-Care YInstrumentation
c c c
III. Y YAnalytes
c c
Chapter Y18. YAmino Y Acids, YPeptides, Yand YProteins
c c c c c c
Chapter Y19. YSerumYEnzymes c c c
Chapter Y20. YTumor YMarkers Yand YCancer YGenes
c c c c c c
Chapter Y21. YKidneyYFunction YTests Y— YCreatinine, YGFR, YUrea, Yand YUric YAcid
c c c c c c c c c c c
Chapter Y22. YCarbohydrates c c
Chapter Y23. YLipids, YLipoproteins, YApolipoproteins, Y and YOther YCardiac YRisk YFactors
c c c c c c c c c
Chapter Y24.YElectrolytes Yand YBlood YGases
c c c c c
Chapter Y25. YHormones c c
Chapter Y26. Y Catecholamines Yand YSerotonin
c c c c
Chapter Y27. Y YVitamins, YTraceYElements, YNutritional Y Assessment
c c c c c c c
Chapter Y28. YHemoglobin, YIron, Y and YBilirubin
c c c c c
Chapter Y29.YPorphyrins Yand YPorphyrias
c c c c
Chapter Y30. YTherapeutic YDrugs Yand YTheir YManagement
c c c c c c
Chapter Y31. YClinicalYToxicologyc c c
Chapter Y32. Y Toxic YMetals c c c
IV. Y YPathophysiology
c c
Chapter Y33. YDiabetes c c
,Chapter Y34. Y Cardiovascular YDisease
c c c
Chapter Y35. YKidneyYDisease
c c c
Chapter Y36. Y PhysiologyYand YDisordersYofYWater, YElectrolyte, Y and YAcid-Base YMetabolism
c c c c c c c c c c
Chapter Y37. Y YLiver YDisease
c c c c
Chapter Y38. Y Gastrointestinal Yand YPancreatic YDiseases
c c c c c
Chapter Y39. Y YDisorders YofYBone Yand YMineral YMetabolism
c c c c c c c c
Chapter Y40. Y YDisorders YofYthe YPituitaryYGland
c c c c c c c
Chapter Y41. Y DisordersYofYthe YAdrenal YCortex
c c c c c c
Chapter Y42. Y Thyroid YDisorders
c c c
Chapter Y43. Y Reproduction-Related YDisorders
c c c
Chapter Y44. Y YPregnancyYand YPrenatalYTesting
c c c c c c
Chapter Y45. Y Newborn YScreening Yand Y Inborn YErrors YofYMetabolism
c c c c c c c c
Chapter Y46. YPharmacogenetics
c c
V. Y YMolecular YDiagnostics
c c c
Chapter Y47. YPrinciples YofYMolecular YBiology
c c c c c
Chapter Y48. YNucleic Y Acid YTechniques Yand YApplications
c c c c c c
Chapter Y49. YGenomes Yand YNucleic YAcid YAlterations
c c c c c c
, TO YGET YALL YCHAPTERS YEMAIL YME YAT>>>>> Y Y Y
c c c c c c c c c
c Y
TO YGET YALL YCHAPTERS YEMAIL YME YAT>>>>> Y Y Y
c c c c c c c c c
c Y
ChapterY01: YClinical YChemistry, YMolecularYDiagnostics, YandYLaboratory YMedicine
c c c c c c c c
Y TestBank
c
MULTIPLE YCHOICE c
1. An Yindividual Yworking Yin Ya Yclinical YchemistryYlaboratoryYis Ymarried Yto Ya Ysales Yrepresentative
c c c c c c c c c c c c c
c who Yworks Yfor Ya YcompanyYthat Y sells Ychemistry YlaboratoryYsupplies. YWhen Ythe Ylaboratory
Y c c c c c c c c c c c c
cY manager Y requests Ya Ylist Y of Yneeded Ysupplies, Y cost Yof Ysupplies, Y and Yvendors, Ythis Y individual c c c c c c c c c c c c c
Yonly Y recommends Ythe Yspouse’sYcompanyYas Ythe Yvendor. YThis Y is Yconsidered Y to Ybe Ya(n):
c c c c c c c c c c c c c c
a. accounting Yissue. c
b. possible Yconflict Y ofYinterest. c c c
c. maintenance YofYconfidentialityYissue. c c c
d. problemYwith Yresource Yallocation. c c c
ANS: Y B c
ConcernYhas YbeenYraised Yover YtheYinterrelationships YbetweenYpractitioners Y inYthe Ymedical
c c c c c c c c c c c
Yfield Y and YcommercialYsuppliers Yof Ydrugs, Y devices, Y equipment, Y etc.,Yto Ythe Ymedical
c c c c c c c c c c c c
Yprofession.
c
Similarly, Yrelationships Yhave Ybeen Yscrutinized Y between Yclinical Ylaboratorians Yand
c c c c c c c c
cY manufacturers Yand Yproviders YofYdiagnostic Yequipment Y and Ysupplies. Y These Yconcerns Y led Ythe c c c c c c c c c c c
cY National YInstitutesYof YHealth Y(NIH) Yin Y1995 Yto Yrequire Yofficial YinstitutionalYreview Yof c c c c c c c c c c c c
Yfinancial Y disclosureYbyYresearchers Yand Y management Y ofYsituations Y inYwhich Ydisclosure
c c c c c c c c c c c
Yindicates Ypotential Y conflictsYof Yinterest.
c c c c c
DIF: 1 REF: Y Y YPageY4-5 c c c c OBJ: Y 6 Y |Y7 c c c
2. AYpatient Y visits Yher YphysicianYstating Ythat Y her Yprescribed Ypainkiller Y is Ynot Yworking Yto
c c c c c c c c c c c c c
creduce Y the Ypain Yfollowing Yher Yrecent Y surgery. Y A Yfriend YofYthe Ypatient Y claims Ythat Ythe
Y c c c c c c c c c c c c c c
Y
csame Ypainkiller Y “worked Ywonders” Yto Yreduce Yher YpainYafter Ythe Ysame Ysurgery. YThe
c c c c c c c c c c c c
Yphysician YstatesYthat Ythe Y difference Yin Ythe Yeffect Yof Ythe Ydrug Ymight Y be Ycaused Yby
c ,c c c c c c c c c c c c c c
Y which Yis Ystudied Y in Y pharmacogenetics.
c c c c c
a. epidemiology
b. anYinheritedYdisease c c
c. aYconflict YofYinterest c c c
d. aYgeneticYvariation YinYdrug-metabolizing Yenzymes
c c c c c
ANS: Y D c
Pharmacogenetics Yis YtheYstudyYofYtheYgenetic YvariationYofYdrugYmetabolism Ybetween c c c c c c c c c c c
cY individuals.
DIF: 1 REF: Y Y YPageY3 c c c c OBJ: Y 1 c
3. JohnYworks YinYa Y molecular Ydiagnostics YlaboratoryYand Yreceives Ya Yblood Ysample Ythat Y has Ythe
c c c c c c c c c c c c c c
c nameYofYa Yclose Yfriend Yprinted YonYthe Ybar-codedYlabel. YTheYgenetic YtestYthat Y isYordered
Y c c c c c c c c c c c c c c c
YonYthe Y friend’s Ysample Ywould Yprovide Ydiagnostic Y information Yabout Y a Ydisorder Ythat Yhas
c c c c c c c c c c c c c
Ya Ypoor Y prognosis, Y and Ythe Ytest Y is YusuallyYperformed Yby YJohn. Y He Yasks Ya Y fellow
c c c c c c c c c c c c c c c