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c Molecular Diagnostics,
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8th Editionby Nader Rifai,PhD
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Chapters 1- 49c c c c
,Tietz Fundamentals of Clinical Chemistry and Molecular Diagnostics 8th Edition Test Bank
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Table of contents:
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I. Principles Of Laboratory Medicine
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Chapter 1. Clinical Chemistry, Molecular Diagnostics, and LaboratoryMedicine
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Chapter 2. Selection and Analytical Evaluation of Methods — With Statistical Techniques
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Chapter 3. Clinical Evaluation of Methods
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Chapter 4. Evidence-Based LaboratoryMedicine
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Chapter 5. Establishment and Use of Reference Values
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Chapter 6. Specimen Collection, Processing, and Other Preanalytical Variables
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Chapter 7. QualityManagement
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II. Analytical Techniques And Instrumentation
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Chapter 8. Principles of Basic Techniques and LaboratorySafety
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Chapter 9. Optical Techniques
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Chapter 10. Electrochemistryand Chemical Sensors
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Chapter 11. Electrophoresis
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Chapter 12. Chromatography
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Chapter 13. Mass Spectrometry
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Chapter 14. Enzyme and Rate Analyses
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Chapter15. Immunochemical Techniques
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Chapter 16 Automationc c
Chapter 17. Point-of-Care Instrumentation
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III. Analytesc
Chapter 18. Amino Acids, Peptides, and Proteins
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Chapter 19. Serum Enzymes
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Chapter 20. Tumor Markers and Cancer Genes
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Chapter 21. Kidney Function Tests — Creatinine, GFR, Urea, and Uric Acid
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Chapter 22. Carbohydrates
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Chapter 23. Lipids, Lipoproteins, Apolipoproteins, and Other Cardiac Risk Factors
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Chapter 24. Electrolytes and Blood Gases
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Chapter 25. Hormones c c
Chapter 26. Catecholamines and Serotonin
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Chapter 27. Vitamins, Trace Elements, Nutritional Assessment
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Chapter 28. Hemoglobin, Iron, and Bilirubin
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Chapter 29. Porphyrins and Porphyrias
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Chapter 30. Therapeutic Drugs and Their Management
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Chapter 31. Clinical Toxicology
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Chapter 32. Toxic Metals
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IV. Pathophysiology
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Chapter 33. Diabetes c c
,Chapter 34. Cardiovascular Disease
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Chapter 35. KidneyDisease
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Chapter 36. Physiology and Disorders of Water, Electrolyte, and Acid-Base Metabolism
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Chapter 37. Liver Disease
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Chapter 38. Gastrointestinal and Pancreatic Diseases
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Chapter 39. Disorders of Bone and Mineral Metabolism
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Chapter 40. Disorders of the PituitaryGland
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Chapter 41. Disorders of the Adrenal Cortex
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Chapter 42. Thyroid Disorders
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Chapter 43. Reproduction-Related Disorders
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Chapter 44. Pregnancyand Prenatal Testing
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Chapter 45. Newborn Screening and Inborn Errors of Metabolism
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Chapter 46. Pharmacogenetics
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V. Molecular Diagnostics
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Chapter 47. Principles of Molecular Biology
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Chapter 48. Nucleic Acid Techniques and Applications
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Chapter 49. Genomes and Nucleic Acid Alterations
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, Chapter01:Clinical Chemistry,Molecular Diagnostics,andLaboratoryMedicine Test
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Bank
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MULTIPLECHOICE c
1. An individual working in a clinical chemistry laboratory is married to a sales representative who
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works for a company that sells chemistry laboratory supplies. When the laboratory manager
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requests alist of needed supplies, cost of supplies, and vendors, this individual onlyrecommends
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the spouse’s companyas the vendor. This is considered to be a(n):
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a. accountingissue. c
b. possibleconflict of interest. c c c
c. maintenanceof confidentialityissue. c c c
d. problemwith resourceallocation. c c c
ANS: B c
Concernhas been raised overtheinterrelationships betweenpractitioners in themedical fieldand
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commercial suppliers of drugs, devices, equipment, etc., to themedical profession.
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Similarly, relationships have been scrutinized between clinical laboratorians and manufacturers c c c c c c c c c
and providers of diagnostic equipment and supplies. These concerns led the National Institutes of
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Health (NIH) in 1995 to require official institutional review of financial disclosurebyresearchers
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and management of situations inwhich disclosureindicates potentialconflicts of interest.
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DIF: 1 REF: Page 4-5 cc c c OBJ: 6 |7 c c c
2. A patient visits her physician stating that her prescribed painkiller is not working to reduce the
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pain followingher recent surgery. A friend of the patient claims that the same painkiller“worked
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wonders” to reduce her pain after the same surgery. The physician states that the differencein the
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effect of thedrugmight be caused by
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pharmacogenetics.
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a. epidemiology
b. aninheriteddisease c c
c. aconflictofinterest c c c
d. ageneticvariation in drug-metabolizingenzymes
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ANS: D c
Pharmacogenetics is thestudyofthe geneticvariation ofdrugmetabolism between c c c c c c c c c c c
individuals.
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DIF: 1 REF: Page 3 cc c c OBJ: 1 c
3. John works in a molecular diagnostics laboratory and receives a blood sample that has the name of
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a close friend printed onthe bar-coded label. Thegenetic test that isordered on thefriend’s sample
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would provide diagnostic information about a disorder that has a poor prognosis, and the test is
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usually performed by John. He asks a fellow employee to analyzethesample forhim and not
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divulge the results. This ethical issue concerns:
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a. confidentialityofpatient geneticand medical information. c c c c c c
b. aconflict ofinterest. c c c
c. resourceallocation. c
d. diagnosticaccuracy. c