USMLE STEP 1 RAPID REVIEW EXAM QUESTIONS &
CORRECT DETAILED ANSWERS
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - CORRECT
ANSWER >>>Budd-Chiari syndrome
Achilles tendon xanthoma - CORRECT ANSWER >>>Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - CORRECT ANSWER >>>Waterhouse-Friderichsen
syndrome (meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - CORRECT ANSWER
>>>Marfan's (fibrillin defect)
Athlete with polycythemia - CORRECT ANSWER >>>Erythropoietin injection
Back pain, fever, night sweats, weight loss - CORRECT ANSWER >>>Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - CORRECT ANSWER >>>Sarcoid
Blue sclera - CORRECT ANSWER >>>Osteogenesis imperfecta
Bluish line on gingiva - CORRECT ANSWER >>>Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) -
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,CORRECT ANSWER >>>Paget's
Bounding pulses, diastolic hear murmur, head bobbing - CORRECT ANSWER >>>Aortic regurg
Café-au-lait spots, Lisch nodules - CORRECT ANSWER >>>NF (1 = optic glimoas and pheo, 2 =
acoustic Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - CORRECT ANSWER
>>>McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - CORRECT ANSWER >>>Duchenne's muscular dystrophy
Cherry-red spot on macula - CORRECT ANSWER >>>Tay-Sachs, Niemann-Pick, central retinal
artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - CORRECT ANSWER
>>>Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - CORRECT ANSWER >>>Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - CORRECT ANSWER
>>>Slapped cheek - B19
Chorea, dementia, caudate degeneration - CORRECT ANSWER >>>Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - CORRECT ANSWER
>>>McArdle's (muscle phosphorylase deficiency)
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, Cold intolerance - CORRECT ANSWER >>>Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - CORRECT ANSWER >>>Internuclear
ophthalmoplegia (MS or stroke)
Continuous machinery heart murmur - CORRECT ANSWER >>>PDA
Cutaneous/dermal edema due to CT expansion - CORRECT ANSWER >>>Myxedema
Dark purple skin / mouth nodules - CORRECT ANSWER >>>Kaposi's sarcoma
Deep, labored breathing / hyperventilation - CORRECT ANSWER >>>Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - CORRECT ANSWER >>>Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - CORRECT ANSWER >>>Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resulting in infection - CORRECT ANSWER >>>Pasteurella multocida (local
cellulitis)
Dry eyes, dry mouth, arthritis - CORRECT ANSWER >>>Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia - CORRECT
ANSWER >>>Plummer-Vinson syndrome
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CORRECT DETAILED ANSWERS
Abdominal pain, ascites, hepatomegaly, (also high D dimer, CHF without JVD) - CORRECT
ANSWER >>>Budd-Chiari syndrome
Achilles tendon xanthoma - CORRECT ANSWER >>>Familial hypercholesterolemia
Adrenal hemorrhage, hypotension, DIC - CORRECT ANSWER >>>Waterhouse-Friderichsen
syndrome (meningococcemia)
Arachnodactyly, lens dislocation, aortic dissection, hyperflexible joints - CORRECT ANSWER
>>>Marfan's (fibrillin defect)
Athlete with polycythemia - CORRECT ANSWER >>>Erythropoietin injection
Back pain, fever, night sweats, weight loss - CORRECT ANSWER >>>Pott's (TB to the vertebrae)
Bilateral hilar adenopathy, uveitis - CORRECT ANSWER >>>Sarcoid
Blue sclera - CORRECT ANSWER >>>Osteogenesis imperfecta
Bluish line on gingiva - CORRECT ANSWER >>>Burton's line - lead poisoning
Bone pain, bone enlargement, arthritis, (also increased hat size, fracture, increased alk phos) -
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,CORRECT ANSWER >>>Paget's
Bounding pulses, diastolic hear murmur, head bobbing - CORRECT ANSWER >>>Aortic regurg
Café-au-lait spots, Lisch nodules - CORRECT ANSWER >>>NF (1 = optic glimoas and pheo, 2 =
acoustic Schwannomas)
Café-au-lait spots, polyostotic fibrous dysplasia, precocious puberty - CORRECT ANSWER
>>>McCune-Albright syndome (G protein problem)
Calf pseudohypertrophy - CORRECT ANSWER >>>Duchenne's muscular dystrophy
Cherry-red spot on macula - CORRECT ANSWER >>>Tay-Sachs, Niemann-Pick, central retinal
artery occlusion
Chest pain, pericardial effusion/friction rub, persistent fever following MI - CORRECT ANSWER
>>>Dressler's (autoimmune post-MI)
Child uses arms to stand up from squat - CORRECT ANSWER >>>Gower's sign (Duchenne's)
Child with fever develops red rash on face that spreads to body - CORRECT ANSWER
>>>Slapped cheek - B19
Chorea, dementia, caudate degeneration - CORRECT ANSWER >>>Huntington's
Chronic exercise intolerance with myalgia, fatigue, painful cramps - CORRECT ANSWER
>>>McArdle's (muscle phosphorylase deficiency)
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, Cold intolerance - CORRECT ANSWER >>>Hypothyroidism
Conjugate lateral gaze palsy, horizontal diplopia - CORRECT ANSWER >>>Internuclear
ophthalmoplegia (MS or stroke)
Continuous machinery heart murmur - CORRECT ANSWER >>>PDA
Cutaneous/dermal edema due to CT expansion - CORRECT ANSWER >>>Myxedema
Dark purple skin / mouth nodules - CORRECT ANSWER >>>Kaposi's sarcoma
Deep, labored breathing / hyperventilation - CORRECT ANSWER >>>Kussmaul breathing, DKA
Dermatitis, dementia, diarrhea - CORRECT ANSWER >>>Pellagra (B3 / niacin deficiency)
Dilated cardiomyopathy, edema, polyneuropathy - CORRECT ANSWER >>>Wet beriberi (B1 /
thiamine deficiency)
Dog or cat bite resulting in infection - CORRECT ANSWER >>>Pasteurella multocida (local
cellulitis)
Dry eyes, dry mouth, arthritis - CORRECT ANSWER >>>Sjogren's syndrome
Dysphagia (esophageal webs), glossitis (smooth tongue), iron deficiency anemia - CORRECT
ANSWER >>>Plummer-Vinson syndrome
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