,Chapter 01: Highlights of the Innate and Adaptive Immune Systems
JA JA JA JA ji JA JA ji JA
MULTIPLEJACHOICE
1. The―father‖ofimmunologyisgenerallyconsideredtobe
a. Koch.
b. Pasteur.
c. Gram.
d. Salk.
ANS:J A J A B
Louis PasteurJAisJAgenerallyconsidered toJAbeJAthe ―fatherJAofJAimmunology.‖
ji ji ji
DIF:J A J A CognitiveJALevel:JAI
2. AnJAearlyJAformJAofJAimmunizationJAwasJApracticedJAbythe
a. Romans.
b. Greeks.
c. Chinese.
d. NativeJAAmericans.
ANS:J A J A C
Beginning aboutJA1000JAAD,JAtheJAChineseJApracticedJAaJAformJAofJAimmunizationJAbyinhalingJAdriedJA
ji
powdJAersJAderivedJAfromJAtheJAcrustsJAofJAsmallpoxJAlesions.
DIF:J A J A CognitiveJALevel:JAI
3. AJAspecificJAfunctionJAofJAtheJAimmuneJAsystem isJAto ji
a. recognizeJAselfJAfromJAnonself.
b. defendJAtheJAbodyJAagainstJAnonself.
c. amplifyspecificJ A functions.
d. BothJAAJAandJAB.
ANS:J A J A D
TheJAfunctionJAofJAtheJAimmuneJAsystemJAisJAtoJArecognize selfJAfromJAnonselfJAandJAdefendJAtheJAbodyJAa
ji
gainst J A nonself.JASuchJAaJAsystemJAisJAnecessaryJAforJAsurvival.JATheJAimmuneJAsystemJAalsoJAhas nons
ji ji
pecificJAeffectJAorJAmechanismsJAthatJAusuallyJAamplifyJAtheJAspecificJAfunctions.JANonspecificJAcomp
onentsJAofJAtheJAimmuJAneJAsystemJAincludeJAmononuclearJAphagocytes,JApolymorphonuclearJAleukoc
ytes,JAandJAsolubleJAfactorsJA(e.g.,JAcomplement).
DIF:J A J A CognitiveJALevel:JAI
4. AnJAundesirableJAconsequenceJAofJAimmunityJAis
a. naturalJAresistance.
b. acquiredJAresistanceJAto infectiousJAdiseases.
ji
, c. anJAautoimmuneJAdisorder.
d. recoveryfrom infectiousJ A disease.
ji
ANS:J A J A C
TheJAdesirableJAconsequencesJAofJAimmunityJAincludeJAnaturalJAresistance,JArecovery,JAandJAacquiredJA
resisJAtanceJAtoJAinfectiousJAdiseases.JAAJAdeficiencyorJAdysfunctionJAofJAtheJAimmuneJAsystemJAcanJAcau
seJAmanyJAdiJAsorders.JAUndesirable consequencesJAofJAimmunityJAinclude allergy,JArejectionJAofJAaJAtr
ji ji
ansplantedJAorgaJAn,JAorJAanJAautoimmuneJAdisorder.
DIF:J A J A CognitiveJALevel:JAI
5. TheJAimmuneJAsystemJAhasJAvariousJAdistinctiveJAcharacteristicsJAexcept;
a. specificity.
b. memory.
c. mobility.
d. noncooperationJAamongJAdifferentJAcells.
ANS:J A J A D
TheJAimmuneJAsystemJAisJAcomposedJAofJAaJAlarge,JAcomplexJAsetJAofJAwidelyJAdistributedJAelements,JAwit
hJAtheJAdistinctiveJAcharacteristicsJAofJAspecificity,JAmemory,JAmobility,JAreplicability,JAandJAcooperati
onJAamongJAdifferentJAcellsJAorJAcellularJAproducts.JASpecificityJAandJAmemoryJAareJAcharacteristicsJAofJA
lymphocytesJAinJAtheJAimmuneJAsystem.JANonspecificJAelementsJAofJAtheJAimmune system demonstrate
ji ji
JAmobility.JAInJAadditiJAon,JAspecificJAandJAnonspecificJAcellularJAcomponentsJAofJAtheJAimmuneJAsystemJA
canJAreplicate.JACooperatioJAnJAisJArequiredJAforJAoptimalJAfunctioning,JAandJAinteractionJAinvolvesJAspe
cific cellularJAelements,JAcellJAproJAducts,JAand nonlymphoidJAelements.
ji ji
DIF:J A J A CognitiveJALevel:JAI
6. HematopoiesisJAoccursJAinJAtheJAyolkJAsacJAduringJAthe
a. immediateJAhoursJAafterJAconception
b. secondJAmonthJAofJAgestation.
c. secondJAtrimesterJAofJAgestation.
d. periodsJAofJAsevereJAanemiaJAinJAchildren.
ANS:J A J A A
TheJAsitesJAofJAbloodJAcellJAdevelopment,JAorJAhematopoiesis,JAfollowJAaJAdefiniteJAsequenceJAinJAtheJAe
mbryoJAandJAfetus.JAHematopoiesisJAoccursJAinJAtheJAyolkJAsacJAduringJAtheJAsecondJAmonthJAofJAgestat
ion.
DIF: CognitiveJALevel:JAII
7. TheJAsequenceJAofJAblood cellJAdevelopmentJAinJAtheJAembryoJAandJAfetusJAis
ji
a. yolkJAsac,JAliver-spleen,JAboneJAmarrow.
b. yolkJAsac,JAboneJAmarrow,JAliver/spleen.
c. liver-spleen,JAyolkJAsac,JAboneJAmarrow.
d. boneJAmarrow,JAliver-spleen,JAyolk sac.ji
ANS:J A J A A
, TheJAfirstJAblood cells areJAprimitiveJAred bloodJAcellsJA(erythroblasts;JARBCs)JAformedJAin theJAisletsJA
ji ji ji ji
ofJAthJAeJAyolk sacJAduringJAtheJAfirstJA2JAtoJA8JAweeksJAofJAlife.JAGradually,JAtheJAliverJAandJAspleenJAreplac
ji
eJAtheJAyolkJAsaJAcJAasJAtheJAsitesJAofJAbloodJAcellJAdevelopment.JAByJAtheJAsecondJAmonthJAofJAgestation,JA
theJAliverJAbecomesJAtheJAmajorJAsiteJAofJAhematopoiesis,JAand granularJAtypesJAofJAleukocytesJAhaveJA
ji
madeJAtheirJAinitialJAappearanc
e. TheJAliverJAandJAspleenJApredominateJAfromJAaboutJA2JAtoJA5JAmonthsJAofJAfetalJAlife.JAInJAtheJAfourthJAm
onthJAofJAgestation,JAboneJAmarrowJAbeginsJAtoJAproduceJAbloodJAcells.JAAfterJAthe fifthJAfetalJAmonth,JA
ji
boneJAmarrowJAbeginsJAto assumeJAitsJAultimateJAroleJAasJAtheJAprimaryJAsiteJAofJAhematopoiesis.
ji
DIF: CognitiveJALevel:JAII
8. TheJAprimaryJAfunctionJAofJAmatureJAneutrophilsJAis
a. toJAreduceJAinflammation.
b. toJAlyseJAparasitesJAinJAtheJAcirculatoryJAsystem.
c. antigenJArecognition.
d. phagocytosis.
ANS:J A J A D
VariousJAphagocyticJAcellsJAcontinuallyJAcirculateJAthroughoutJAtheJAblood,JAlymph,JAgastrointestinalJA
systJAem,JAandJArespiratoryJAtract.JAWhenJAtraumaJAoccurs,JAtheJAneutrophilsJAarriveJAatJAtheJAsiteJAofJAinj
uryJAand canJAbeJAfoundJAin theJAinitialJAexudateJAinJAlessJAthanJA1JAhour.JAMonocytesJAareJAslowerJAinJAmo
ji ji
vingJAtoJAtheJAinflammJAatoryJAsite.JAMacrophagesJAresident inJAtheJAtissuesJAofJAtheJAbodyJAare alreadyJAi
ji ji
n placeJAtoJAdealJAwithJAan intrJAudingJAagent.JAAdditionalJAmacrophagesJAfromJAtheJAboneJAmarrowJAandJA
ji ji
otherJAtissuesJAcanJAbeJAreleasedJAinJAsJAevereJAinfections.
DIF: CognitiveJALevel:JAII
9. PrimaryJAgranules,JAorJAazurophilicJAgranules,JAinJAneutrophilsJAcontain
a. lysozyme.
b. myeloperoxidase.
c. lactoferrin.
d. BothJAAJAandJAB.
ANS:J A J A D
GranulesJAinJAtheJAphagocyteJAcytosolJAcontainJAdegradatoryJAenzymesJAofJAthreeJAtypes
1. Primary,JAorJAazurophilic,JAgranulesJAcontaining enzymesJA(e.g.,JAlysozy
ji
me,JAmyeloperoxidase)
2. Secondary,JAorJAspecific,JAgranulesJAcontaining substancesJAsuchJAasJAlactoferrin.
ji
3. TertiarygranulesJAcontainingJAsubstancesJAsuchJAasJAcaspases
DIF:J A J A CognitiveJALevel:JAI
10. TheJAoriginJAofJAaJAcondition whenJAeosinophilsJAareJAincreasedJAin theJAcirculating bloodJAisJAassociat
ji ji ji
edJAwJAith:
a. fungus
b. parasiticJAamoeba
c. allergic reactions
ji
d. bacteria
ANS:J A J A C
JA JA JA JA ji JA JA ji JA
MULTIPLEJACHOICE
1. The―father‖ofimmunologyisgenerallyconsideredtobe
a. Koch.
b. Pasteur.
c. Gram.
d. Salk.
ANS:J A J A B
Louis PasteurJAisJAgenerallyconsidered toJAbeJAthe ―fatherJAofJAimmunology.‖
ji ji ji
DIF:J A J A CognitiveJALevel:JAI
2. AnJAearlyJAformJAofJAimmunizationJAwasJApracticedJAbythe
a. Romans.
b. Greeks.
c. Chinese.
d. NativeJAAmericans.
ANS:J A J A C
Beginning aboutJA1000JAAD,JAtheJAChineseJApracticedJAaJAformJAofJAimmunizationJAbyinhalingJAdriedJA
ji
powdJAersJAderivedJAfromJAtheJAcrustsJAofJAsmallpoxJAlesions.
DIF:J A J A CognitiveJALevel:JAI
3. AJAspecificJAfunctionJAofJAtheJAimmuneJAsystem isJAto ji
a. recognizeJAselfJAfromJAnonself.
b. defendJAtheJAbodyJAagainstJAnonself.
c. amplifyspecificJ A functions.
d. BothJAAJAandJAB.
ANS:J A J A D
TheJAfunctionJAofJAtheJAimmuneJAsystemJAisJAtoJArecognize selfJAfromJAnonselfJAandJAdefendJAtheJAbodyJAa
ji
gainst J A nonself.JASuchJAaJAsystemJAisJAnecessaryJAforJAsurvival.JATheJAimmuneJAsystemJAalsoJAhas nons
ji ji
pecificJAeffectJAorJAmechanismsJAthatJAusuallyJAamplifyJAtheJAspecificJAfunctions.JANonspecificJAcomp
onentsJAofJAtheJAimmuJAneJAsystemJAincludeJAmononuclearJAphagocytes,JApolymorphonuclearJAleukoc
ytes,JAandJAsolubleJAfactorsJA(e.g.,JAcomplement).
DIF:J A J A CognitiveJALevel:JAI
4. AnJAundesirableJAconsequenceJAofJAimmunityJAis
a. naturalJAresistance.
b. acquiredJAresistanceJAto infectiousJAdiseases.
ji
, c. anJAautoimmuneJAdisorder.
d. recoveryfrom infectiousJ A disease.
ji
ANS:J A J A C
TheJAdesirableJAconsequencesJAofJAimmunityJAincludeJAnaturalJAresistance,JArecovery,JAandJAacquiredJA
resisJAtanceJAtoJAinfectiousJAdiseases.JAAJAdeficiencyorJAdysfunctionJAofJAtheJAimmuneJAsystemJAcanJAcau
seJAmanyJAdiJAsorders.JAUndesirable consequencesJAofJAimmunityJAinclude allergy,JArejectionJAofJAaJAtr
ji ji
ansplantedJAorgaJAn,JAorJAanJAautoimmuneJAdisorder.
DIF:J A J A CognitiveJALevel:JAI
5. TheJAimmuneJAsystemJAhasJAvariousJAdistinctiveJAcharacteristicsJAexcept;
a. specificity.
b. memory.
c. mobility.
d. noncooperationJAamongJAdifferentJAcells.
ANS:J A J A D
TheJAimmuneJAsystemJAisJAcomposedJAofJAaJAlarge,JAcomplexJAsetJAofJAwidelyJAdistributedJAelements,JAwit
hJAtheJAdistinctiveJAcharacteristicsJAofJAspecificity,JAmemory,JAmobility,JAreplicability,JAandJAcooperati
onJAamongJAdifferentJAcellsJAorJAcellularJAproducts.JASpecificityJAandJAmemoryJAareJAcharacteristicsJAofJA
lymphocytesJAinJAtheJAimmuneJAsystem.JANonspecificJAelementsJAofJAtheJAimmune system demonstrate
ji ji
JAmobility.JAInJAadditiJAon,JAspecificJAandJAnonspecificJAcellularJAcomponentsJAofJAtheJAimmuneJAsystemJA
canJAreplicate.JACooperatioJAnJAisJArequiredJAforJAoptimalJAfunctioning,JAandJAinteractionJAinvolvesJAspe
cific cellularJAelements,JAcellJAproJAducts,JAand nonlymphoidJAelements.
ji ji
DIF:J A J A CognitiveJALevel:JAI
6. HematopoiesisJAoccursJAinJAtheJAyolkJAsacJAduringJAthe
a. immediateJAhoursJAafterJAconception
b. secondJAmonthJAofJAgestation.
c. secondJAtrimesterJAofJAgestation.
d. periodsJAofJAsevereJAanemiaJAinJAchildren.
ANS:J A J A A
TheJAsitesJAofJAbloodJAcellJAdevelopment,JAorJAhematopoiesis,JAfollowJAaJAdefiniteJAsequenceJAinJAtheJAe
mbryoJAandJAfetus.JAHematopoiesisJAoccursJAinJAtheJAyolkJAsacJAduringJAtheJAsecondJAmonthJAofJAgestat
ion.
DIF: CognitiveJALevel:JAII
7. TheJAsequenceJAofJAblood cellJAdevelopmentJAinJAtheJAembryoJAandJAfetusJAis
ji
a. yolkJAsac,JAliver-spleen,JAboneJAmarrow.
b. yolkJAsac,JAboneJAmarrow,JAliver/spleen.
c. liver-spleen,JAyolkJAsac,JAboneJAmarrow.
d. boneJAmarrow,JAliver-spleen,JAyolk sac.ji
ANS:J A J A A
, TheJAfirstJAblood cells areJAprimitiveJAred bloodJAcellsJA(erythroblasts;JARBCs)JAformedJAin theJAisletsJA
ji ji ji ji
ofJAthJAeJAyolk sacJAduringJAtheJAfirstJA2JAtoJA8JAweeksJAofJAlife.JAGradually,JAtheJAliverJAandJAspleenJAreplac
ji
eJAtheJAyolkJAsaJAcJAasJAtheJAsitesJAofJAbloodJAcellJAdevelopment.JAByJAtheJAsecondJAmonthJAofJAgestation,JA
theJAliverJAbecomesJAtheJAmajorJAsiteJAofJAhematopoiesis,JAand granularJAtypesJAofJAleukocytesJAhaveJA
ji
madeJAtheirJAinitialJAappearanc
e. TheJAliverJAandJAspleenJApredominateJAfromJAaboutJA2JAtoJA5JAmonthsJAofJAfetalJAlife.JAInJAtheJAfourthJAm
onthJAofJAgestation,JAboneJAmarrowJAbeginsJAtoJAproduceJAbloodJAcells.JAAfterJAthe fifthJAfetalJAmonth,JA
ji
boneJAmarrowJAbeginsJAto assumeJAitsJAultimateJAroleJAasJAtheJAprimaryJAsiteJAofJAhematopoiesis.
ji
DIF: CognitiveJALevel:JAII
8. TheJAprimaryJAfunctionJAofJAmatureJAneutrophilsJAis
a. toJAreduceJAinflammation.
b. toJAlyseJAparasitesJAinJAtheJAcirculatoryJAsystem.
c. antigenJArecognition.
d. phagocytosis.
ANS:J A J A D
VariousJAphagocyticJAcellsJAcontinuallyJAcirculateJAthroughoutJAtheJAblood,JAlymph,JAgastrointestinalJA
systJAem,JAandJArespiratoryJAtract.JAWhenJAtraumaJAoccurs,JAtheJAneutrophilsJAarriveJAatJAtheJAsiteJAofJAinj
uryJAand canJAbeJAfoundJAin theJAinitialJAexudateJAinJAlessJAthanJA1JAhour.JAMonocytesJAareJAslowerJAinJAmo
ji ji
vingJAtoJAtheJAinflammJAatoryJAsite.JAMacrophagesJAresident inJAtheJAtissuesJAofJAtheJAbodyJAare alreadyJAi
ji ji
n placeJAtoJAdealJAwithJAan intrJAudingJAagent.JAAdditionalJAmacrophagesJAfromJAtheJAboneJAmarrowJAandJA
ji ji
otherJAtissuesJAcanJAbeJAreleasedJAinJAsJAevereJAinfections.
DIF: CognitiveJALevel:JAII
9. PrimaryJAgranules,JAorJAazurophilicJAgranules,JAinJAneutrophilsJAcontain
a. lysozyme.
b. myeloperoxidase.
c. lactoferrin.
d. BothJAAJAandJAB.
ANS:J A J A D
GranulesJAinJAtheJAphagocyteJAcytosolJAcontainJAdegradatoryJAenzymesJAofJAthreeJAtypes
1. Primary,JAorJAazurophilic,JAgranulesJAcontaining enzymesJA(e.g.,JAlysozy
ji
me,JAmyeloperoxidase)
2. Secondary,JAorJAspecific,JAgranulesJAcontaining substancesJAsuchJAasJAlactoferrin.
ji
3. TertiarygranulesJAcontainingJAsubstancesJAsuchJAasJAcaspases
DIF:J A J A CognitiveJALevel:JAI
10. TheJAoriginJAofJAaJAcondition whenJAeosinophilsJAareJAincreasedJAin theJAcirculating bloodJAisJAassociat
ji ji ji
edJAwJAith:
a. fungus
b. parasiticJAamoeba
c. allergic reactions
ji
d. bacteria
ANS:J A J A C