NR 565 / NR565 Advanced Pharmacology Fundamentals Final Exam Study Guide | LATEST 2020 / 2021 |Chamberlain College

NR 565 / NR565 Advanced Pharmacology Final Exam Study Guide | Chamberlain College Drug Pharmacodynamic Pharmacotherapeutics Clinical use Drug interactions Adverse drug reactions spectrum Dosing and monitoring education Antimycobacterials, isonziad TB therapy. Interferes with lipid and nucleic biosynthesis, inhibit synthesis of mycolic acids. Needs combined thearpy Genetics – how metabolized in liver. Careful with alcohol intake, drug abuse, pregnant, neuropathy. TB – four drug therapy. Alcohol, coumadin, benzo Peripheral neuropathy, hepatotoxicity, ototxity, thrombocytopenia. TB CYP450 four drugs for two months then two for 4-7. Izonaid 5-15m/kg, rifampin 600 daily, eth 15-25 Full course completion, nutrition, rests, exercise. Antivirals, neucleoside analogues Herpes, zoester, varicella. Interfere with DNA synthesis and viral replication Poorly absorbed – distributed throughout the body. Dose adjustments in renal function HSV, zoster, varicella, gingivostamatitis Probenecide, nephrotoxic, theophylline, dig n/v/d, dizzy, confusion, tremor HIV Rash, temp, bun Acyclovir 200 q4. Hydration, renal failure and enceophapathic changes. Tx first sign of rash,loose clothing – partner must take Antifungals, fluconazole Years and dermatophytes, inhibit fungal enzyme and fights against active yest. Absorption enhance with food, cyp450 and 341. Hepatotoxicity, reduce when creat <50, pregnant c Years, dermatophytes, needs loading dose. Rifampin, h2, cyp3a4, cyp450 Hepatotoxicity, cpy450 3a4, GI, prolong qt Candida, cryptococcus, endemic, dermo Liver enzyme, bilirubin Fluc 150. Take with food, no alcohol use, liver toxicity Anthelminthics, -azole Parasytic infections, ringworm. Bind to microtubes to inhibit polymerization and loss of function. Minimal, pregnant c Pinworm, whipworm, roundweorm, hookworm, threadworm, scabies. Dex, cimetidine N/V/D. neutropenia. Mazotti reaction. worms Stool stample. Mebendazole, pamoate, albenzole, scabies ivermectin High fat meals, ivermectin on empty stomach. Vigorous hygiene Antiprotazoals, metronidazole and tinidazole Disrupt dna and protein synthesis Paracytic and bacterial infections. Trichomonas, cdif. Oral, distributed into fluids. Caution with sz and clots. Pregnant b T vafinalis, lamblia, bacteria vainosis, h pylori. Not in first timester Coumadin, cyp450, lithium Anorexia, abd pain, dizziness, metallic taste . Trich, giardiasis leukopenia Watch metallic taste, no alcohol. condoms