NBME CBSE - QUESTIONS AND ANSWERS (ACTUAL
TEST) Latest 2025\2026 Graded A+
62 year old woman - osteoporosis - a bisphosphonate is prescribed. The
expected beneficial effect of the drug is due to which of the following? Correct
Ans - Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among
those who exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8).
Which of the following is the conclusion about the effect of exercise on the
risk of hip fracture? Correct Ans - Statistically Significant Overall
Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while
shoveling snow. Pulse is 80/min and blood pressure is 130/70. The most
immediate treatment mechanism of action? Correct Ans
- Increased nitric oxide concentration
24 year old woman - spilled hot grease on her left leg while working at a fast-
food restaurant. Exam of leg shows 7cm pink, soft, granular, edematous
wound. The formation of this tissue was most likely caused by increased
,activity of which? Correct Ans - a.
Vascular Endothelial Growth Factor VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
,27 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull
fracture - increased serum osm and decreased urin osm. Following
desmopressin urine osm increases. Desmopressin's effect is due to the
activation of which of the following? Correct Ans - a. Adenylyl
Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10 month old boy - 4 day history of fever and cough. He attends day care
center. Chest exam shows intercostal retractions along with bilateral, diffuse
wheezes and expiratory rhonchi. The infectious agent most likely has which of
the following properties? Correct Ans - Mediation of Cell Entry via a
fusion protein
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light
headedness but no difficulty swallowing- Bilateral wheezing - Which is most
appropriate pharmacotherapy for this patient?
Correct Ans - B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late
afternoon. 1 week of fatigue. He recentaly had sex with one partner. Physical
exam show cervical lymphadenopathy and pharyngeal erythema with a
creamy exudate. DX? Correct Ans - Infectious Mononucleosis
, 57 year old man - radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The
progressive tumor growth is due to a defect in cell cycle arrest in which of the
following phases of cell cycle? Correct Ans - G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of
100.4 - imaging shows bilateral hydroureter and hydronephrosis. Biopsy
shows marked fibrosis and scattered granulomas. DX? Correct Ans -
Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion
and man has two gene deletion. If the two gene is trans - what percentage of
offspring will have a two gene deletion? Correct Ans - 50%
previously healthy 40 year brought to emergency department by her husband
- 2 day history of fever, lethargy, confusion. PE shows scattered petechiae and
ecchymoses over the lower extremities - 3+ polychromasia and 3+
schistocytes and Low platelets Dx? Correct Ans - Thrombotic
Thrombocytopenia Purpura
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol,
TEST) Latest 2025\2026 Graded A+
62 year old woman - osteoporosis - a bisphosphonate is prescribed. The
expected beneficial effect of the drug is due to which of the following? Correct
Ans - Decreased Osteoclast Activity
Cohot Study of elderly women - relative risk ratio for hip fractures among
those who exercise regularly is 1.2 (95% confidence interval of 1.1 to 1.8).
Which of the following is the conclusion about the effect of exercise on the
risk of hip fracture? Correct Ans - Statistically Significant Overall
Increase Risk
52 year old man goes to ER with chest pain radiating to his jaw while
shoveling snow. Pulse is 80/min and blood pressure is 130/70. The most
immediate treatment mechanism of action? Correct Ans
- Increased nitric oxide concentration
24 year old woman - spilled hot grease on her left leg while working at a fast-
food restaurant. Exam of leg shows 7cm pink, soft, granular, edematous
wound. The formation of this tissue was most likely caused by increased
,activity of which? Correct Ans - a.
Vascular Endothelial Growth Factor VEGF - stimulates angiogenesiss.
TYPE III Collagen = Blood Vessels - early wound repair
,27 year old man- MVC - skull x-ray shows a linear, nondepressed basal skull
fracture - increased serum osm and decreased urin osm. Following
desmopressin urine osm increases. Desmopressin's effect is due to the
activation of which of the following? Correct Ans - a. Adenylyl
Cyclase
Adenylate Cyclase - ATP - CAMP -- PROTEKINASE A -- Ca v2
A 10 month old boy - 4 day history of fever and cough. He attends day care
center. Chest exam shows intercostal retractions along with bilateral, diffuse
wheezes and expiratory rhonchi. The infectious agent most likely has which of
the following properties? Correct Ans - Mediation of Cell Entry via a
fusion protein
A 17 year old girl in ED - 15 minutes after being stung by a bee. Mild light
headedness but no difficulty swallowing- Bilateral wheezing - Which is most
appropriate pharmacotherapy for this patient?
Correct Ans - B2- Agonist
14 year old boy - 2 day history of sore throat and fever that peaks in late
afternoon. 1 week of fatigue. He recentaly had sex with one partner. Physical
exam show cervical lymphadenopathy and pharyngeal erythema with a
creamy exudate. DX? Correct Ans - Infectious Mononucleosis
, 57 year old man - radiation therapy for squamous cell carcinoma of the lung.
Despite therapy, tumor increases in size and he dies 6 months later. The
progressive tumor growth is due to a defect in cell cycle arrest in which of the
following phases of cell cycle? Correct Ans - G1
28 year old - lived in sub-Saharan Africa - until he came to the US. Temp of
100.4 - imaging shows bilateral hydroureter and hydronephrosis. Biopsy
shows marked fibrosis and scattered granulomas. DX? Correct Ans -
Schistosomiasis
A couple with a family history of a-thalassemia. Woman has one gene deletion
and man has two gene deletion. If the two gene is trans - what percentage of
offspring will have a two gene deletion? Correct Ans - 50%
previously healthy 40 year brought to emergency department by her husband
- 2 day history of fever, lethargy, confusion. PE shows scattered petechiae and
ecchymoses over the lower extremities - 3+ polychromasia and 3+
schistocytes and Low platelets Dx? Correct Ans - Thrombotic
Thrombocytopenia Purpura
49 year old woman - coronary artery disease - BP 140/90 - High Cholesterol,
