PATHOPHYSIOLOGY EXAM 2 VERSIONS
2025/2026 BANK ACTUAL QUESTIONS WITH
DETAILED ANSWERS AND OA READINESS
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A newborn's screening for cystic fibrosis is positive. An
advanced practice registered nurse (APRN) is reviewing
screening results and taking a comprehensive genetic
screening of the parents. The APRN asks the parents
questions to help determine the transmission of this
disease.
Which question should the APRN ask?
A) "Do you wish to have maternal genetic testing done?"
B) "Are either of you showing symptoms of cystic
fibrosis?"
C) "Are you both the genetic donor parents?"
,D) "Do any of your siblings have cystic fibrosis?" -
....ANSWER...C) "Are you both the genetic donor
parents?"
A 30-day-old infant presents to the emergency room with
decreased oral intake, decreased urine output, and a fever
of 101.8. The infant is admitted for further evaluation
with a workup to include a blood culture, a urine culture, a
spinal tap, and a chest X-ray.
Which issue of innate immunity, as it relates to neonates,
is of concern?
A) High levels of mannose-binding lectin
B) Relative deficiency of factor B
C) Excess collectin and collectin-like protein
D) Dysfunctional chemotactic factor response -
....ANSWER...B) Relative deficiency of factor B
A 12-year-old African American patient presents with
unilateral eye swelling and lower lip swelling. The patient's
parent reports that the swelling is spontaneous and
resolves over several days. The patient does not have
complaints of fever, hives, or vomiting. Serum lab results
,show hyperactivation of three plasma protein systems.
The APRN suspects hereditary angioedema.
What is the cause of the genetic defect suspected in this
situation?
A) Hageman factor
B) Plasminogen
C) C1 esterase inhibitor
D) Bradykinin - ....ANSWER...C) C1 esterase inhibitor
The parent of a child diagnosed with Down syndrome
expresses concerns about the child's recurrent respiratory
tract infections to an advanced practice registered nurse
(APRN). The infections have occurred regularly since
birth.
What should the APRN tell the parent is the underlying
cause of this illness?
A) Hypertonia causes airway restriction.
B) Hyperthyroidism causes an increased risk of infection.
C) Gastroesophageal reflux disease causes aspiration of thin
fluids.
, D) Short stature causes poor lung development. -
....ANSWER...C) Gastroesophageal reflux disease causes
aspiration of thin fluids.
A 36-year-old patient is being seen by an advanced
practice registered nurse (APRN) in a primary care clinic
for the first time. The patient reports feeling depressed due
to a major life change. Additional symptoms include
weight gain, sedentary activity, and insomnia. The APRN
plans on providing the patient with several exercises to
reduce the physiological effect of stress.
Why is the APRN concerned about relieving this
emotional response?
A) It decreases glucose uptake.
B) It increases protein synthesis.
C) It increases smooth muscle contraction. -
....ANSWER...A) It decreases glucose uptake.
An 80-year-old patient brings her grandchildren with her
to a routine medical appointment. The patient has
moderate chronic obstructive pulmonary disease (COPD)
and is concerned about developing pneumonia because of
its increased incidence at the senior center.