ANCC Domain 1- Scientific Foundation
Questions and Answers | Latest Version
| 2025/2026 | Correct & Verified
Which neurotransmitter is most associated with mood regulation and depression?
A. Dopamine
✔✔B. Serotonin
C. Acetylcholine
D. GABA
The hypothalamic-pituitary-adrenal (HPA) axis is primarily involved in:
✔✔A. Stress response
B. Motor coordination
C. Immune surveillance
D. Sensory processing
Which part of the brain is primarily responsible for memory formation?
A. Thalamus
B. Hypothalamus
1
,✔✔C. Hippocampus
D. Cerebellum
Which class of medication blocks dopamine receptors in the treatment of schizophrenia?
A. SSRIs
✔✔B. Antipsychotics
C. Benzodiazepines
D. Mood stabilizers
Which hormone is released in response to stress and is measured in cortisol testing?
A. Oxytocin
B. Insulin
✔✔C. Cortisol
D. Estrogen
Which lab test is most appropriate to monitor when prescribing lithium?
A. AST
✔✔B. Serum lithium level
2
,C. Hemoglobin A1c
D. BNP
What is the primary mechanism of action of SSRIs?
✔✔A. Inhibit serotonin reuptake
B. Block dopamine
C. Increase GABA activity
D. Decrease norepinephrine
Which vitamin deficiency is associated with Wernicke’s encephalopathy?
A. Vitamin B6
✔✔B. Vitamin B1 (Thiamine)
C. Vitamin D
D. Vitamin B12
What does neuroplasticity refer to?
A. The brain's hormonal regulation
B. The degeneration of neurons over time
3
, ✔✔C. The brain’s ability to reorganize itself
D. The brain's ability to form new organs
Which neurotransmitter is most involved in the reward system and addiction?
A. Serotonin
✔✔B. Dopamine
C. Acetylcholine
D. GABA
What is the function of the amygdala in the brain?
✔✔A. Emotional processing, especially fear
B. Muscle coordination
C. Verbal memory
D. Balance
Which type of imaging is best for viewing brain structures in schizophrenia?
✔✔A. MRI
B. X-ray
4
Questions and Answers | Latest Version
| 2025/2026 | Correct & Verified
Which neurotransmitter is most associated with mood regulation and depression?
A. Dopamine
✔✔B. Serotonin
C. Acetylcholine
D. GABA
The hypothalamic-pituitary-adrenal (HPA) axis is primarily involved in:
✔✔A. Stress response
B. Motor coordination
C. Immune surveillance
D. Sensory processing
Which part of the brain is primarily responsible for memory formation?
A. Thalamus
B. Hypothalamus
1
,✔✔C. Hippocampus
D. Cerebellum
Which class of medication blocks dopamine receptors in the treatment of schizophrenia?
A. SSRIs
✔✔B. Antipsychotics
C. Benzodiazepines
D. Mood stabilizers
Which hormone is released in response to stress and is measured in cortisol testing?
A. Oxytocin
B. Insulin
✔✔C. Cortisol
D. Estrogen
Which lab test is most appropriate to monitor when prescribing lithium?
A. AST
✔✔B. Serum lithium level
2
,C. Hemoglobin A1c
D. BNP
What is the primary mechanism of action of SSRIs?
✔✔A. Inhibit serotonin reuptake
B. Block dopamine
C. Increase GABA activity
D. Decrease norepinephrine
Which vitamin deficiency is associated with Wernicke’s encephalopathy?
A. Vitamin B6
✔✔B. Vitamin B1 (Thiamine)
C. Vitamin D
D. Vitamin B12
What does neuroplasticity refer to?
A. The brain's hormonal regulation
B. The degeneration of neurons over time
3
, ✔✔C. The brain’s ability to reorganize itself
D. The brain's ability to form new organs
Which neurotransmitter is most involved in the reward system and addiction?
A. Serotonin
✔✔B. Dopamine
C. Acetylcholine
D. GABA
What is the function of the amygdala in the brain?
✔✔A. Emotional processing, especially fear
B. Muscle coordination
C. Verbal memory
D. Balance
Which type of imaging is best for viewing brain structures in schizophrenia?
✔✔A. MRI
B. X-ray
4
