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Exam (elaborations)

NR 507 Midterm Exam 2025/2026 – Advanced Pathophysiology Practice Questions, Answer Key, and Study Guide (Chamberlain College of Nursing)

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NR 507 Midterm Exam 2025/2026 – Advanced Pathophysiology Practice Questions, Answer Key, and Study Guide (Chamberlain College of Nursing) NR 507 Midterm 2025 – Advanced Pathophysiology Exam Practice Questions, Study Guide, and Answer Key (Chamberlain College of Nursing)

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Uploaded on
August 1, 2025
Number of pages
16
Written in
2025/2026
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A 30-year-old client who donates blood every 3 months


Which client should the nurse practitioner (NP)
recognize as most at risk of developing iron
deficiency anemia?

A 25-year-old client who recently became
pregnant
A 40-year-old client with a history of peptic
ulcers
A 30-year-old client who donates blood every 3
months
A 50-year-old client with congestive heart failure




Serum ferritin


The nurse practitioner (NP) reviews a client's
laboratory results. Which laboratory result best
reflects the client's level of iron stores?

Transferrin saturation
Hemoglobin
Serum iron
Serum ferritin
Hematocrit
Total iron-binding capacity




a bloos transfusion
The nurse practitioner (NP) is caring for a client
with beta thalassemia major. The NP should
anticipate the client will require what?


Avoid drinking tea or coffee with meals
Consume lean red meat
Consume iron-fortified cereal
The nurse practitioner (NP) is counseling a client
with iron deficiency anemia about dietary needs. Consume vitamin C-rich foods with iron-rich meals
Which instruction(s) should the NP include?
Select all that apply.

Avoid drinking tea or coffee with meals
Consume lean red meat
Increase intake of calcium-rich foods
Consume iron-fortified cereal
Consume vitamin C-rich foods with iron-rich
meals



Refer the couple for genetic counseling.
Explain what it means to be a carrier of thalassemia.
Discuss inheritance patterns of thalassemia.
A nurse practitioner (NP) is providing pre-
conception counseling to a couple, both of whom
are carriers of thalassemia. Which of the
following actions should the NP take? Select all
that apply.

Encourage the couple not to conceive.
Refer the couple for genetic counseling.
Explain what it means to be a carrier of
thalassemia.
Discuss ways to prevent naturally conceiving a
child with thalassemia.
Discuss inheritance patterns of thalassemia.

, Ferritin level
Hemoglobin level
Energy level
The nurse practitioner (NP) assesses the client on
a follow-up visit after the initiation of treatment
for thalassemia including administration of blood
transfusions. What three (3) assessments should
the NP prioritize to evaluate client outcomes?
Select 3.

Dietary intake
Developmental milestones
Ferritin level
Hemoglobin level
Energy level




Adult client who had a vertical sleeve gastrectomy


Which of the following clients should the nurse
practitioner (NP) recognize as being most at risk
for developing vitamin B-12 deficiency anemia?

An infant who is exclusively breastfed
Middle adult client who eats a high-protein diet
A client who is pregnant
Adult client who had a vertical sleeve
gastrectomy




Mean Corpuscular Hemoglobin Concentration indicates hemoglobin concentration in RBCs
(MCHC)

Ferritin total iron stores; low levels indicate iron deficiency

small RBC's
-iron deficiency
microlytic anemia -thalassemia


blood transfusion- will increase iron stores
Chelation therapy-deferasirox & deferiprone
Thalassemia beta major treatment bone marrow transplant


Mediated by IgE antibody
Type 1 hypersensitivity Anaphylaxis, allergic rhinitis, asthma

mediated by IgG antibodies and macrophages
Type 2 hypersensitivity HITT reaction, transfusion reaction, Graves Disease

IgG antibodies attach the TSH receptor causing an over production of thyroid hormones leading
the hyperthyroidism

Graves disease tx: beta blockers for tachycardia, methimazole (not for pregnant), propylthiouracil (for
pregnant), radioactive iodine therapy (not for pregnant)



neutrophil mediated reaction
immune complexes activate complement system & neutrophils resulting in tissue destruction
Type 3 hypersensitivity -Lupus, serum sickness




B&T cells are over reactive causing production of antibodies
DX with ANA antibody
systemic lupus erythematosus TX with NSAIDS for pain

, A 30-year-old client with severe anorexia nervosa
A 27-year-old client who is newly pregnant and breastfeeding their toddler
A 40-year-old client with celiac disease
Which of the following client(s) should the nurse
practitioner (NP) recognize as being at risk for
developing folate deficiency? Select all that
apply.

A 30-year-old client with severe anorexia
nervosa
A 19-year-old client with sickle cell disease
A 27-year-old client who is newly pregnant and
breastfeeding their toddler
A 40-year-old client with celiac disease
A 32-year-old client who had a gastrectomy one
year ago




Metformin, H2 receptor blockers, PPI
What medications impact the absorption of B12

anticonvulsants and methotrexate
What medications impact the absorption of folate

Defective erythropoiesis​


A nurse practitioner (NP) evaluates a 45-year-old
client who presents with fatigue and weakness.
The NP diagnoses the client with anemia of
chronic disease. What is the primary
pathophysiological mechanism causing this
normocytic anemia?​

Excessive blood loss​
Defective erythropoiesis​
Impaired iron absorption​
Delayed maturation of erythrocyte precursors​




Increased red blood cell destruction


A nurse practitioner (NP) evaluates a 28-year-old
client who presents with fatigue, jaundice, and
dark-colored urine. The NP diagnoses the client
with hemolytic anemia. What is the most likely
pathophysiological mechanism causing this
normocytic anemia? ​

Impaired iron absorption​
Excessive blood loss​
Defective erythropoiesis​
Increased red blood cell destruction​




50-year-old who experienced a transfusion reaction after a blood transfusion​


Which client should the nurse practitioner (NP)
recognize as most at risk for developing
hemolytic anemia?​

60-year-old with a history of iron-deficiency
anemia​
35-year-old who recently underwent surgery for
a bleeding ulcer​
50-year-old who experienced a transfusion
reaction after a blood transfusion​
28-year-old with a family history of thalassemia​

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